Naresuan University Journal
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The effect of loading direction and Sn alloying on the deformation modes of Zr: An in-situ neutron diffraction study
No full textStatistical mechanics of ontology based annotations
No full textWe present a statistical mechanical theory of the process of annotating an object with terms selected from an ontology. The term selection process is formulated as an ideal lattice gas model, but in a highly structured inhomogeneous field. The model enables us to explain patterns recently observed in real-world annotation data sets, in terms of the underlying graph structure of the ontology. By relating the external field strengths to the information content of each node in the ontology graph, the statistical mechanical model also allows us to propose a number of practical metrics for assessing the quality of both the ontology, and the annotations that arise from its use. Using the statistical mechanical formalism we also study an ensemble of ontologies of differing size and complexity; an analysis not readily performed using real data alone. Focusing on regular tree ontology graphs we uncover a rich set of scaling laws describing the growth in the optimal ontology size as the number of objects being annotated increases. In doing so we provide a further possible measure for assessment of ontologies
The history of very: the directionality of functional shift and (inter)subjectification
No full textOn the basis of extensive corpus analysis, we reconstruct the history of very and the paths of change along which it acquired new meanings. We propose an analytical model that, firstly, assigns general semantic functions to the (sub)modifier relations in the English noun phrase and, secondly, identifies subsenses of these functions on the basis of collocational, semantic and pragmatic distinctions observed in different contexts. Thus, we arrive at a comprehensive description of the various (sub)modifier relations in which very has functioned in its history. Having been borrowed into English as part of fixed collocations such as very Ihus (‘the true Jesus’), and croice verra (‘the true cross’), very successively acquired the functions of descriptive modifier, noun-intensifier, focus marker, adjective-intensifier, classifier, postdeterminer-intensifier, quantifier-intensifier and postdeterminer. This description allows us to interpret the history of very as a paradigm case of progressive grammaticalization and (inter)subjectification involving leftward movement in the English NP (Adamson 2000). Our analytical model allows us to capture finer mechanisms of change such as collocational extension, pragmatically-driven host class expansion, invited inferences and analogy
Interculturalities of English as a lingua franca:International communication and multicultural awareness in the Greek context
No full textTemperature-Dependent DC and Small-Signal Analysis of AlGaAs/InGaAs pHEMT for High-Frequency Applications
No full textTemperature-dependent dc and small-signal analysis have been carried out on 0.5 μm × 200-μm AlGaAs/InGaAs pseudomorphic high-electron mobility transistor over the temperature range from -40 °C to 150 °C by on-wafer S-parameter measurements up to 50 GHz. The thermal behavior of dc and equivalent circuit parameters along with their temperature coefficients was analyzed and reported for the first time using the same device. Most of these parameters show a negative trend with temperature, such as drain-source output current Ids, extrinsic transconductance gm, effective electron velocity veff, threshold voltage VT, Schottky barrier height φb, gate-drain capacitance Cgd, drain-source capacitance Cds, intrinsic transconductance gmo, cutoff frequency ft, and maximum frequency fmax. On the other hand, Two-dimensional electron gas sheet carrier density ns, ON-resistance RON, series resistance Rseries, terminal resistances (Rg, Rs, and Rd), output resistance Rds, input resistance Ri, gate-source capacitance Cgs, and intrinsic delay time τ show a positive trend with temperature. The results provide some valuable insights for future design optimizations of advanced GaAs-based Monolithic microwave integrated circuits.</p
Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care.
No full textOBJECTIVE: To examine long-term organ damage and safety following treatment with belimumab plus standard of care (SoC) in patients with systemic lupus erythematosus (SLE). METHODS: Pooled data were examined from two ongoing open-label studies that enrolled patients who completed BLISS-52 or BLISS-76. Patients received belimumab every four weeks plus SoC. SLICC Damage Index (SDI) values were assessed every 48 weeks (study years) following belimumab initiation (baseline). The primary endpoint was change in SDI from baseline at study years 5-6. Incidences of adverse events (AEs) were reported for the entire study period. RESULTS: The modified intent-to-treat (MITT) population comprised 998 patients. At baseline, 940 (94.2%) were female, mean (SD) age was 38.7 (11.49) years, and disease duration was 6.7 (6.24) years. The mean (SD) SELENA-SLEDAI and SDI scores were 8.2 (4.18) and 0.7 (1.19), respectively; 411 (41.2%) patients had organ damage (SDI = 1: 235 (23.5%); SDI ≥ 2: 176 (17.6%)) prior to belimumab. A total of 427 (42.8%) patients withdrew overall; the most common reasons were patient request (16.8%) and AEs (8.5%).The mean (SD) change in SDI was +0.2 (0.48) at study years 5-6 (n = 403); 343 (85.1%) patients had no change from baseline in SDI score (SDI +1: 46 (11.4%), SDI +2: 13 (3.2%), SDI +3: 1 (0.2%)). Of patients without organ damage at baseline, 211/241 (87.6%) had no change in SDI and the mean change (SD) in SDI was +0.2 (0.44). Of patients with organ damage at baseline, 132/162 (81.5%) had no change in SDI and the mean (SD) change in SDI was +0.2 (0.53). The probability of not having a worsening in SDI score was 0.88 (95% CI: 0.85, 0.91) and 0.75 (0.67, 0.81) in those without and with baseline damage, respectively (post hoc analysis).Drug-related AEs were reported for 433 (43.4%) patients; infections/infestations (282, 28.3%) and gastrointestinal disorders (139, 13.9%) were the most common. CONCLUSION: Patients with SLE treated with long-term belimumab plus SoC had a low incidence of organ damage accrual and no unexpected AEs. High-risk patients with pre-existing organ damage also had low accrual, suggesting a favorable effect on future damage development
Effect of Essential Oil from Hedychium coronarium to Control Acne Vulgaris / ฤทธิ์ของน้ำมันหอมระเหยมหาหงส์ในการยับยั้งเชื้อแบคทีเรียสาเหตุของสิว
No full textบทคัดย่อ
งานวิจัยนี้เป็นการศึกษาฤทธิ์ของน้ำมันหอมระเหยสกัดจากเหง้ามหาหงส์ ในการยับยั้งเชื้อแบคทีเรียที่เป็นสาเหตุหลักของการเกิดสิว ได้แก่ Propionibacterium acnes และ Staphylococcus epidermidis โดยทดสอบฤทธิ์ต้านเชื้อด้วยวิธี disc diffusion ผลการศึกษาพบว่า น้ำมันหอมระเหยมหาหงส์มีฤทธิ์ยับยั้งการเจริญเติบโตของเชื้อที่เป็นสาเหตุของสิวได้เช่นเดียวกับยา Amoxicillin และ Erythromycin นอกจากนี้ยังพบว่าน้ำมันหอมระเหยมหาหงส์ยังมีฤทธิ์ฆ่าเชื้อดังกล่าวแม้ว่าจะมีค่า MIC และ MBC อย่างน้อย 1000 ไมโครแกรมต่อมิลลิลิตร ผลการวิเคราะห์องค์ประกอบทางเคมี พบว่าสารประกอบหลักในน้ำมันหอมระเหยเป็นสารจำพวก monoterpene ได้แก่ 1,8-Cineole (39.86%) และ beta-Pinene (21.69%) จากผลการศึกษาแสดงให้เห็นว่าน้ำมันหอมระเหยมหาหงส์มีศักยภาพในการพัฒนาเป็นผลิตภัณฑ์ที่ใช้ยับยั้งเชื้อสิวต่อไป
คำสำคัญ: น้ำมันหอมระเหย มหาหงส์ การยับยั้งแบคทีเรีย Propionibacterium acnes Staphylococcus epidermidis GC-MS 1, 8-Cineole beta-Pinene
Abstract
Antibacterial activity of essential oils from Hedychium coronarium was determined against Propionibacterium acnes and Staphylococcus epidermidis which are the major causes of acne. Antimicrobial susceptibility test was performed by using disc diffusion method. The result showed that both P. acnes and S. epidermidis were inhibited by the essential oil as well as Amoxicillin and Erythromycin. Moreover the essential oil had antibactericidal activity even MIC and MBC value were at least 1000 µg/ml. Hedychium coronarium essential oil was rich in monoterpene, especially 1,8-Cineole (39.86%) and beta-Pinene (21.69%). In conclusion, Hedychium coronarium essential oil had promising potential to develop as a product to control acne.
Keywords: Hedychium coronarium, essential oil, antibacterial activity, Propionibacterium acnes, Staphylococcus epidermidis, GC-MS, 1, 8-Cineole, beta-Pinen
