Naresuan University Journal
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The development and first validation of the Manchester Early Morning Symptoms Index (MEMSI) for patients with COPD.
No full textAIM: Early morning symptoms (EMS) in people with COPD are associated with poor health, impaired activities and increased exacerbation risk. We describe the development and preliminary validation of the Manchester Early Morning Symptom Index (MEMSI) to quantify EMS in COPD. METHODS: Focus groups and cognitive debriefing with patients with COPD were used to develop the potential item list, followed by a cross-sectional study to finalise the items for inclusion. In addition to test-retest reliability, comparisons with the St George's Respiratory Questionnaire-C (SGRQ-C), modified Medical Research Council Dyspnoea Scale, Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) and Hospital Anxiety and Depression Scale (HADS) evaluated construct validity. Hierarchical methods informed item deletion and Rasch analysis was applied to assess scale unidimensionality. RESULTS: 23 items were identified from the focus groups and debriefings. The cross-sectional study involved 203 patients with COPD (mean age 64.7 SD 7.5 years, male 63%, Global Initiative for Chronic Obstructive Lung Disease (GOLD): 1:14% 2:41% 3:25% 4: 7%). 13 items were removed during item reduction. MEMSI contains 10 items, demonstrates good overall fit to the Rasch model (χ(2) p=0.26) and item score distribution; excellent reliability (Person Separation Index: 0.91) and good test-retest repeatability (r=0.82). It correlates with the SGRQ-C (r=0.73), FACIT-F (r=-0.65) and HADS (r=0.53-0.54) indicating good construct validity. CONCLUSIONS: MEMSI is a reliable and valid unidimensional measure of EMS for patients with COPD. It is simple to use and score supporting its suitability for research and clinical use. Work is underway to determine the minimal clinical important difference and cross-cultural validity
Effects of flow forming parameters on the development of residual stresses in Cr-Mo-V steel tubes
No full textEdema extension distance: an outcome measure for phase II clinical trials targeting edema after intracerebral haemorrhage
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Search for long-lived, weakly interacting particles that decay to displaced hadronic jets in proton-proton collisions at TeV with the ATLAS detector
No full textCorporate Acquisitions and Financial Constraints
No full textUsing a large sample of US acquisitions made between 1985 and 2013, we study the effect of financial constraints on acquisition gains and acquisition likelihood. Our findings show that financial constraints of target companies significantly increase acquisition premiums and abnormal returns for both parties. Our results further show that the presence of financial constraints in the target is one of the most important determinants of a takeover bid. This supports the idea that acquisitions may improve the ability of financially constrained companies to access capital through a better reallocation of resources within segments of the same company (e.g., internal capital market) or through better access to external markets. This would eventually benefit bidders too, as new capital would be invested in valuable growth opportunities that otherwise would expire unexercised
A demonstration of position angle-only weak lensing shear estimators on the GREAT3 simulations
No full textWe develop and apply the position angle-only shear estimator of Whittaker et al. (2014) to realistic galaxy images. This is done by demonstrating the method on the simulations of the GREAT3 challenge (Mandelbaum et al. 2014b), which include contributions from anisotropic PSFs. We measure the position angles of the galaxies using three distinct methods - the integrated light method, quadrupole moments of surface brightness, and using model-based ellipticity measurements provided by IM3SHAPE. A weighting scheme is adopted to address biases in the position angle measurements which arise in the presence of an anisotropic PSF. Biases on the shear estimates, due to measurement errors on the position angles and correlations between the measurement errors and the true position angles, are corrected for using simulated galaxy images and an iterative procedure. The properties of the simulations are estimated using the deep field images provided as part of the challenge. A method is developed to match the distributions of galaxy fluxes and half-light radii from the deep fields to the corresponding distributions in the field of interest. We recover angle-only shear estimates with a performance close to current well-established model and moments-based methods for all three angle measurement techniques. The Q-values for all three methods are found to be Q{\textasciitilde}400. The code is freely available online at http://www.jb.man.ac.uk/{\textasciitilde}mbrown/angle\_only\_shear/
