Naresuan University Journal
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The Role and the Implications of Online Reviews for the Relationship between Consumers and Online Service Firms
No full textDoxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose.
No full textThere is a small proportion of cells within a tumour with self-renewing properties, which is resistant to conventional therapy, and is responsible for tumour initiation, maintenance and metastasis. These cells are known as cancer stem cells (CSCs) or tumour-initiating cells (TICs) [1]. Recent publications identify several antibiotics, such as salinomycin or doxycycline, as selective CSCs inhibitors [2-4]. However, the mechanisms of action of these antibiotics on CSCs are not fully understood
Casting the Lean Spell: The Promotion, Dilution and Erosion of Lean Management in the NHS:The promotion, dilution, and erosion of lean management in the NHS
No full textLean thinking has recently re-emerged as a fashionable management philosophy, especially in public services. A prescriptive or mainstream literature suggests that lean is rapidly diffusing into public sector environments, providing a much-needed rethink of traditional ways of working and stimulating performance improvements. Our study of the introduction of lean in a large UK public sector hospital challenges this argument. Based on a three-year ethnographic study of how employees make sense of lean ‘adoption’, we describe a process in which lean ideas were initially championed, later diluted and ultimately eroded. While initially functioning as a ‘mechanism of hope’ (Brunsson, 2006) around which legitimacy could be generated for tackling longstanding work problems, over time both ‘sellers’ and ‘buyers’ of the concept mobilized lean in ambiguous ways, to the extent that the notion was rendered somewhat meaningless. Ultimately our analysis rejects current prescriptive or managerialist discourses on lean while offering support for prior positions that would explain such management fashions in terms of the ‘life cycle of a fad’
The Impact of Research Funding on Scientific Outputs: Evidence from Six Smaller European Countries
No full textWe investigate the relationships between the citation impacts of scientific papers and the sources of funding that are acknowledged as having supported those publications. We examine several relationships potentially associated with funding, including first citation, total citations, and the chances of becoming highly cited. Furthermore, we explore the links between citations and types of funding by organization and also with combined measures of funding. In particular, we examine the relationship between funding intensity and funding variety and citation. Our empirical work focuses on six small advanced European economies, applying a zero inflated negative binomial model to a set of more than 240,000 papers authored by researchers from these countries. We find that funding is not related to the first citation but is significantly related to the number of citations and top percentile citation impact. Additionally, we find that citation impact is positively related to funding variety and negatively related with funding intensity. Finally there is an inverse relationship between the relative frequency of funding and citation impact. The results presented in the paper provide insights for the design of research programs and the structure of research funding and for the behavior and strategies of research and sponsoring organizations
Disraeli and the Archi-Textual: Constructions of Authority in Sybil
No full textThis essay undertakes a re-reading of Disraeli’s novel Sybil (1845), arguing that the novel engages in the construction of authority as a lost origin which is also projected into the future as a political goal. The essay draws on Derrida’s concept of the ‘supplement’ to trace how the text combines names, buildings and documents in ‘archi-textual’ structures that seek to establish and secure this lost authority. The tension between the need to construct authority and the need to project it as a pre-existing origin can never be settled and operates as a driving force within the text
Government in the catching-up of technology innovation: Case of administrative intervention in China
No full textThis paper advances the extant knowledge of the mechanism of government intervention in technology innovation, especially that in the catching-up context. It forms a three-layer theoretical framework and further uses it to analyze a case of the standardization of TD-SCDMA, a third generation (3G) of mobile system, in China. The findings validate the argument that in technology development and technology diffusion stages, there are different innovation task foci and different challenges, which require the government taking a mix of regulative, financial and administrative instruments to intervene. The government needs to draw upon the institutional environment, R&D and industrialization capability and the technology characteristics of the innovation in identifying the innovation tasks and challenges, and determining the intervention strategy. In the catching-up context, when pursuing the indigenous innovation in complex technology, "hard" government intervention is necessary. Especially the government should take advantage of its control of national economy and the industry to explore the potential of intervention using diverse administrative instruments, for example the leading role of state organizations in innovation should be considered
