Naresuan University Journal
Not a member yet
39887 research outputs found
Sort by
Adjuvant Hormone Therapy May Improve Survival in Epithelial Ovarian Cancer: Results of the AHT Randomized Trial.
No full textPURPOSE: To assess the effects of adjuvant hormone therapy (AHT) on survival and disease outcome in women with epithelial ovarian cancer. PATIENTS AND METHODS: Participants were premenopausal and postmenopausal women who had been diagnosed with epithelial ovarian cancer (any International Federation of Gynecology and Obstetrics stage) 9 or fewer months previously. Ineligible patients included those with deliberately preserved ovarian function, with a history of a hormone-dependent malignancy, or with any contraindications to hormone-replacement therapy. Patients were centrally randomly assigned in a 1:1 ratio to either AHT for 5 years after random assignment or no AHT (control). Main outcome measures were overall survival (OS), defined as time from random assignment to death (any cause), and relapse-free survival, defined as time from random assignment to relapse or death (any cause). Patients who continued, alive and relapse free, were censored at their last known follow-up. RESULTS: A total of 150 patients (n = 75, AHT; n = 75, control) were randomly assigned from 1990 to 1995 from 19 centers in the United Kingdom, Spain, and Hungary; all patients were included in intention-to-treat analyses. The median follow-up in alive patients is currently 19.1 years. Of the 75 patients with AHT, 53 (71%) have died compared with 68 (91%) of 75 patients in the control group. OS was significantly improved in patients who were receiving AHT (hazard ratio, 0.63; 95% CI, 0.44 to 0.90; P = .011). A similar effect was seen for relapse-free survival (hazard ratio, 0.67; 95% CI, 0.47 to 0.97; P = .032). Effects remained after adjustment for known prognostic factors. CONCLUSION: These results show that women who have severe menopausal symptoms after ovarian cancer treatment can safely take hormone-replacement therapy, and this may, in fact, infer benefits in terms of OS in addition to known advantages in terms of quality of life
Tomography Defined as Sensor Fusion
No full textTomography is introduced as a sensing task, ratherthan a healthcare imaging application, best known for itsembodiment in hospital scanners. Tomography sensing, imagingand data processing are summarized with emphasis on systemphenomenology and design in relation with the inversion ofmeasurement data. The main classification paradigms of sensorfusion are examined and the overlap with the theory and practiceof computer (‘hard-field’) tomography is shown in detail. It isdemonstrated how concurrent fusion takes place when measuringpath integrals; collaborative fusion – when defining a projectionas a set of path integrals to allow data inversion from multipleprojections, e.g. through the Fourier slice theorem;complementary fusion – when imaging the object in several autoregisteredsecondary contrasts. To cover the largest varietyavailable, process tomography (i.e. non-medical tomography)case studies are examined in detail revealing the fusion tasksperformed by various algorithms
A qualitative study exploring community pharmacists' awareness of, and contribution to, self-care support in the management of long-term conditions in the United Kingdom
No full textBACKGROUND: Self-care support refers to activities aimed at educating, training and empowering patients with skills and ability to manage [and monitor] their long-term conditions (LTCs). While self-care support by health care professionals has emerged as a distinct concept in the management of LTCs, evidence of community pharmacy's contribution is sparse. OBJECTIVE: The aim was to explore community pharmacy's contribution to self-care support of LTCs. The objectives were to explore how community pharmacists conceptualize self-care support of LTCs and how they operationalize the core elements of this in their practice. METHODS: Semi-structured interviews were conducted with community pharmacists in England (n = 12) and Scotland (n = 12). A framework consisting of the core elements of self-care support (information and advice; skills training and support; technology; support networks; and collaborative care planning) was developed from the literature and was used to structure the interviews and analysis. Analysis was done thematically using the interpretative phenomenological analysis technique. RESULTS: The three main themes that emerged were conceptualization; operationalization of the core elements; and barriers to providing self-care support. Participants conceptualized self-care of LTCs as patients taking responsibility for their own health, performing activities that improved their LTCs and that enabled them to become more independent in managing their LTCs. Their views on self-care support did not reflect this conceptual understanding but was described primarily as providing patients with information and advice rather than actively supporting them. Participants' views of operationalizing the core elements of self-care support was found to be medicines focused, opportunistic and dependent on the services they provided, rather than being patient-centered and proactive. The barriers to providing self-care support of LTCs in community pharmacy were described as priority accorded to dispensing activities, the structure of the community pharmacy contract, lack of incentives to provide self-care support and patients' expectations and lack of awareness of community pharmacy's role in LTCs management. CONCLUSION: Community pharmacists' theoretical understanding of self-care was not reflected in the ways that they portrayed their contributions to self-care support. The current ways in which community pharmacy delivers its services for patient care may need to be re-configured in order to fit into the holistic self-care support paradigm
Paleoneuroanatomy and pneumatic sinuses of the basal alligatoroid Diplocynodon tormis from the Eocene of Spain
No full textFormation of grooved and porous coatings on titanium by plasma electrolytic oxidation in H2SO4 /H3PO4 electrolytes and effects of coating morphology on adhesive bonding.
No full textExperiment and CFD simulation for a lab-scale fluidized bed granulation process with Wurster tube
No full textScreen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.
No full textProtein SUMOylation has emerged as an important regulatory event, particularly in nuclear processes such as transcriptional control and DNA repair. In this context, small ubiquitin-like modifier (SUMO) often provides a binding platform for the recruitment of proteins via their SUMO-interacting motifs (SIMs). Recent discoveries point to an important role for multivalent SUMO binding through multiple SIMs in the binding partner as exemplified by poly-SUMOylation acting as a binding platform for ubiquitin E3 ligases such as ring finger protein 4. Here, we have investigated whether other types of protein are recruited through multivalent SUMO interactions. We have identified dozens of proteins that bind to multi-SUMO platforms, thereby uncovering a complex potential regulatory network. Multi-SUMO binding is mediated through multi-SIM modules, and the functional importance of these interactions is demonstrated for the transcriptional corepressor ZMYM2/ZNF198 where its multi-SUMO-binding activity is required for its recruitment to chromatin
PHOENIX: Public Health and Obesity in England – the New Infrastructure Examined. 2nd Interim report
No full textRadical Futures?:Youth, Politics and Activism in Contemporary Europe
No full textadical Futures? Youth, Politics and Activism in Contemporary Europe features a collection of articles originating from MYPLACE (Memory, Youth, Political Legacy and Civic Engagement), which has mapped the relationship between political heritage, forms and levels of civic and political engagement of young people in Europe, and their potential receptivity to radical and populist political agendas.Explores the meanings of activism among young people engaged in a range of organisations and movementsDraws on new primary data sets from 14 countries collected under a common research design by the authorsChallenges claims of rising ‘apathy’ among young people as well as counter-claims that their participation has simply shifted to ‘informal’ activitiesMakes critical interventions into theory underpinning the fields of youth studies, democratic theory and participation, memory studies, and far right studie
