Naresuan University Journal
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Pregnancy Augments G Protein Estrogen Receptor (GPER) Induced Vasodilation in Rat Uterine Arteries via the Nitric Oxide - cGMP Signaling Pathway
No full textBackground: The regulation of vascular tone in the uterine circulation is a key determinant of appropriate uteroplacental blood perfusion and successful pregnancy outcome. Estrogens, which increase in the maternal circulation throughout pregnancy, can exert acute vasodilatory actions. Recently a third estrogen receptor named GPER (G protein-coupled estrogen receptor) was identified and, although several studies have shown vasodilatory effects in several vascular beds, nothing is known about its role in the uterine vasculature.Aim: The aim of this study was to determine the function of GPER in uterine arteries mainly during pregnancy. Uterine arteries were isolated from nonpregnant and pregnant rats.Methods: Vessels were contracted with phenylephrine and then incubated with incremental doses (10-12-10-5 M) of the selective GPER agonist G1.Results: G1 induced a dose-dependent vasodilation which was: 1) significantly increased in pregnancy, 2) endothelium-dependent, 3) primarily mediated by NO/cGMP pathway and 4) unaffected by BKca channel inhibition.Conclusion: This is the first study to show the potential importance of GPER signaling in reducing uterine vascular tone during pregnancy. GPER may therefore play a previously unrecognized role in the regulation of uteroplacental blood flow and normal fetus growth
Seismic velocity modelling of the Carboneras Fault Zone, SE Spain
No full textThe Carboneras fault zone forms part of a major strike-slip fault systemin SE Spain, striking NE–SW, and accommodating up to 40 km displacement. It affects basement metamorphic rocks and unconformably overlying upper Miocene sediments and volcanic rocks. High-resolution shallowseismic tomographic sectionswere made across the fault zone in two localities. Fromthe same areas, fault rocks and theirwallrocks were collected for laboratory seismic velocity measurements. The laboratory data were corrected for the substantial effects of near-surface crack damage. By combining these results with geological cross sections, forward velocity models for the fault zone were constructed to compare with field seismic measurements and hence to ‘ground-truth’ the inferences made fromthem. These velocity/depth relationships matched moderately well with those extracted fromthe insitu tomography results. Aspects of the in-situ seismic sections matched features on the forward-modelled sections, but the comparisons showed that it is important to have some degree of foreknowledge of the geology to be able successfully to interpret seismic tomography sections as an exploration tool
Music worlds and internal goods: the role of convention
No full textWhat is the basis of the value and pleasure that participants derive from participation in music worlds? Participants often have a great passion for those worlds and for the artists, works, identities and conventions which constitute and populate them. Sociology, however, is not very good at explaining or exploring such passion and commitment. To do this in relation to music requires that we take the pleasures and satisfactions of ‘musicking’ (i.e. all activities pertaining to music) seriously. This paper calls for an interrogation of the mechanisms and dynamics of music’s intrinsic pleasures. We argue that it is necessary to explore the mechanisms involved in the intrinsic pleasures of musicking, and that to do so means analysing the ‘internal goods’ of music worlds and the role that conventions play in the production of pleasure and commitment
The Influence of the Herfindahl-Hirschman Index and Product Complexity on Search Behaviour: A Cross-sector Study of the U.S., Germany and U.K.
No full textA proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting.
No full textMeasurement of the correlations between the polar angles of leptons from top quark decays in the helicity basis at TeV using the ATLAS detector
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