Naresuan University Journal
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Medicines use review (MUR) activity in English community pharmacies: associations with pharmacy type and population need
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Search for the associated production of the Higgs boson with a top quark pair in multilepton final states with the ATLAS detector
No full textMultiscale 3D analysis of creep cavities in AISI type 316 stainless steel
No full textA sample of AISI type 316 stainless steel from a power station steam header, showing reheat cracking, was removed from service and has been examined by a combination of microscale X-ray computed tomography (CT), nanoscale serial section focused ion beam-scanning electron microscopy (FIB-SEM), energy dispersive X-ray (EDX) spectrum imaging and transmission electron microscopy (TEM). Multiscale three-dimensional analysis usingcorrelative tomography allowed key regions to be found and analysed with high resolution ..
Probing the neutron star interior and the Equation of State of cold dense matter with the SKA
No full textWith an average density higher than the nuclear density, neutron stars (NS) provide a unique test-ground for nuclear physics, quantum chromodynamics (QCD), and nuclear superfluidity. Determination of the fundamental interactions that govern matter under such extreme conditions is one of the major unsolved problems of modern physics, and -- since it is impossible to replicate these conditions on Earth -- a major scientific motivation for SKA. The most stringent observational constraints come from measurements of NS bulk properties: each model for the microscopic behaviour of matter predicts a specific density-pressure relation (its `Equation of state', EOS). This generates a unique mass-radius relation which predicts a characteristic radius for a large range of masses and a maximum mass above which NS collapse to black holes. It also uniquely predicts other bulk quantities, like maximum spin frequency and moment of inertia. The SKA, in Phase 1 and particularly in Phase 2 will, thanks to the exquisite timing precision enabled by its raw sensitivity, and surveys that dramatically increase the number of sources: 1) Provide many more precise NS mass measurements (high mass NS measurements are particularly important for ruling out EOS models); 2) Allow the measurement of the NS moment of inertia in highly relativistic binaries such as the Double Pulsar; 3) Greatly increase the number of fast-spinning NS, with the potential discovery of spin frequencies above those allowed by some EOS models; 4) Improve our knowledge of new classes of binary pulsars such as black widows and redbacks (which may be massive as a class) through sensitive broad-band radio observations; and 5) Improve our understanding of dense matter superfluidity and the state of matter in the interior through the study of rotational glitches, provided that an ad-hoc campaign is developed
FetA Antibodies Induced by an Outer Membrane Vesicle Vaccine Derived from a Serogroup B Meningococcal Isolate with Constitutive FetA Expression
No full textInvasive meningococcal disease causes over 3500 cases each year in Europe, with particularly high incidence among young children. Among serogroup B meningococci, which cause most of the cases, high diversity in the outer membrane proteins (OMPs) is observed in endemic situations; however, comprehensive molecular epidemiological data are available for the diversity and distribution of the OMPs PorA and FetA and these can be used to rationally design a vaccine with high coverage of the case isolates. The aim of this study was to determine whether outer membrane vesicles (OMVs) derived from an isolate with constitutive FetA expression (MenPF-1 vaccine) could be used to induce antibodies against both the PorA and FetA antigens. The immunogenicity of various dose levels and number of doses was evaluated in mice and rabbits, and IgG antibody responses tested against OMVs and recombinant PorA and FetA proteins. A panel of four isogenic mutants was generated and used to evaluate the relative ability of the vaccine to induce serum bactericidal activity (SBA) against FetA and PorA. Sera from mice were tested in SBA against the four target strains. Results demonstrated that the MenPF-1 OMVs were immunogenic against PorA and FetA in both animal models. Furthermore, the murine antibodies induced were bactericidal against isogenic mutant strains, suggesting that antibodies to both PorA and FetA were functional. The data presented indicate that the MenPF-1 vaccine is a suitable formulation for presenting PorA and FetA OMPs in order to induce bactericidal antibodies, and that proceeding to a Phase I clinical trial with this vaccine candidate is justified
Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.
No full textA small percentage of asthmatics have 'severe refractory asthma', where there is suboptimal response to currently available therapies. A number of novel therapies targeting key biological targets are becoming available. Asthma is a heterogeneous disease, and systematic evaluation of patients is important to target therapies to the underlying inflammatory subtype and clinical features. This review article outlines new and emerging treatments for severe asthma, including monoclonal antibodies targeting eosinophilic disease, anti-neutrophil strategies, novel bronchodilators and bronchial thermoplasty. We highlight the importance of individualized investigation, treatment and management of severe asthmatics
