Naresuan University Journal
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Mosaic Tetrasomy 9p: A Mendelian Condition Associated With Pediatric-Onset Overlap Myositis.
No full textPediatric-onset inflammatory myositis (IM) and systemic lupus erythematosus (SLE) are rare inflammatory diseases. Both result from the complex interaction of genetic and environmental factors. An increasing number of Mendelian conditions predisposing to the development of SLE have been recently identified. These include monogenic conditions, referred to as the type I interferonopathies, associated with a primary upregulation of type I interferon (IFN), a key cytokine in the pathogenesis of SLE and some cases of IM. Here, we report on a pediatric-onset inflammatory overlap phenotype in a 6-year-old girl who was shown to carry mosaic tetrasomy 9p. The patient presented with myositis overlapping with lupuslike features. Myositis was characterized by a proximal muscular weakness and HLA class I antigen myofiber overexpression on muscle biopsy. Lupus-like manifestations consisted of pericarditis, pleuritis, and positive antinuclear and anti-SSA (Sjögren-syndrome A) antibodies. Complete remission was achieved with corticosteroids and mycophenolate mofetyl. Analysis of tetrasomy 9p showed mosaic tetrasomy in the 9p24.3q12 region, including the type I IFN cluster, and increased expression of IFN-stimulated genes. These data suggest that mosaic tetrasomy 9p can be associated with an upregulation of type I IFN signaling, predisposing to inflammatory myositis and lupus-like features. Thus, unexplained muscle or other organ involvement in patients carrying mosaic tetrasomy of the type IFN cluster of chromosome 9p should lead to the search for IM and/or lupuslike disease, and karyotype should be performed in patients with SLE or IM with mental retardation
The Effects of Learning Activity Management using a Concept Attainment Model Cooperating with Total Physical Response on Mathematical Concept and Learning Retention on Parabola Topic for Mathayomsuksa III Students / ผลการจัดกิจกรรมการเรียนรู้คณิตศาสตร์โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทางที่มีต่อมโนทัศน์ทางคณิตศาสตร์และความคงทนในการเรียนคณิตศาสตร์ เรื่อง พาราโบลาของนักเรียนชั้นมัธยมศึกษาปีที่ 3
No full textงานวิจัยนี้มีวัตถุประสงค์ คือ 1) เพื่อเปรียบเทียบมโนทัศน์ทางคณิตศาสตร์ เรื่อง พาราโบลา ของนักเรียนชั้นมัธยมศึกษาปีที่ 3 ที่ได้ รับการจัดกิจกรรมการเรียนรู้โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทางกับเกณฑ์ร้อยละ 70 และ 2) เพื่อศึกษาความคงทนในการเรียนคณิตศาสตร์ เรื่อง พาราโบลา ของนักเรียนชั้นมัธยมศึกษาปีที่ 3 ที่ได้รับการจัดกิจกรรมการเรียนรู้โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทาง กลุ่มตัวอย่าง ได้แก่ นักเรียนชั้นมัธยมศึกษาปีที่ 3 โรงเรียนดอนทองวิทยา อำเภอเมือง จังหวัดพิษณุโลก ภาคเรียนที่ 2 ปีการศึกษา 2557 จำนวน 25 คน เครื่องมือที่ใช้ในการวิจัย คือ แผนการจัดกิจกรรม การเรียนรู้โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทาง และแบบทดสอบวัดมโนทัศน์ วิเคราะห์ข้อมูลด้วยค่ามัชฌิมเลขคณิต ค่ามัชฌิมเลขคณิตร้อยละ ส่วนเบี่ยงเบนมาตรฐาน และสถิติทดสอบค่าที (t-test) ผลการวิจัย พบว่า 1. นักเรียนชั้นมัธยมศึกษาปีที่ 3 ที่ได้รับการจัดกิจกรรมการเรียนรู้โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทางมีมโนทัศน์ทางคณิตศาสตร์ เรื่อง พาราโบลา สูงกว่าเกณฑ์ร้อยละ 70 อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 2. ความคงทนในการเรียนคณิตศาสตร์ เรื่อง พาราโบลา ของนักเรียนชั้นมัธยมศึกษาปีที่ 3 ที่ได้รับการจัดกิจกรรมการเรียนรู้โดยใช้โมเดลการได้มาซึ่งมโนทัศน์ร่วมกับการสอนแบบตอบสนองด้วยท่าทาง หลังจากการจัดกิจกรรมการเรียนรู้เสร็จและหลังจากการจัดกิจกรรมการเรียนรู้เสร็จ 2 สัปดาห์ ไม่แตกต่างกัน แสดงว่า นักเรียนมีความคงทนในการเรียน คำสำคัญ: โมเดลการได้มาซึ่งมโนทัศน์ การสอนแบบตอบสนองด้วยท่าทาง มโนทัศน์ทางคณิตศาสตร์ ความคงทนในการเรียนคณิตศาสตร์ พาราโบลา AbstractThe research is aimed 1) to compare mathematics concepts Parabola topic of mathayomsuksa 3 being of learning activity management using a Concept Attainment Model cooperating with Total Physical Response with the determined criteria of 70% of the test score. 2) to study mathematics learning retention Parabola topic of matthayomsuksa 3 students being of learning activity management using a Concept Attainment Model cooperating with Total Physical Response. The sample group was 25 students who were studying in matthayomsuksa 3 in the second semester of academic year 2014 at Donthongwitthaya School, Phitsanulok. The research instrument were the lesson plans developed with the use of activity management using a Concept Attainment Model cooperating with Total Physical Response and mathematics concept test. The data were analyzed by mean percentage, standard deviation t-test statistic. The results of the study revealed that 1) Mathematics concept of matthayomsuksa 3 students being of learning activity management using a Concept Attainment Model cooperating with Total Physical Response on Parabola topic were higher than the determined criteria of 70% of the test score at .05 level of statistical significance. 2) Learning retention mathematics Parabola topic of matthayomsuksa 3 students being of learning activity management using a Concept Attainment Model cooperating with Total Physical Response dose exist, confirmed by statistically significant test of the student’ test score after two weeks. Keywords: Concept Attainment Model, Total Physical Response, Mathematical Concept, Mathematical Learning Retention, Parabola
Emotion regulation as a mediator in the relationship between attachment and depressive symptomatology:A systematic review
No full textBackground: Attachment theory has been conceptualised as an emotion regulation theory. Research attributes the occurrence of depressive symptoms to a dysfunction of emotion regulation. Anxious attachment and avoidant attachment, which are two dimensions of insecure attachment, are hypothesised to lead to the development of hyperactivating and deactivating emotion regulation strategies.Methods: This systematic review examines the literature on the role of emotion regulation and its relationship with attachment and depressive symptomatology. Furthermore, we examined evidence for hyperactivating and deactivating strategies.Results: Nineteen papers were identified. Adolescent studies demonstrated associations of varying strength and found unreliable and contradictory results for emotion regulation as a mediator. Conversely, adult studies provided strong evidence for emotion regulation as a mediator. The hypothesis that hyperactivating strategies mediate anxious attachment and depressive symptoms was consistently supported. Mixed evidence was provided for deactivating strategies as mediators to avoidant attachment and depressive symptomatology.Limitations: Limitations of methodology and quality of studies are identified with particular attention drawn to problems with conceptual singularity and multicollinearity.Conclusions: Despite mixed variable findings, this review indicates that emotion regulation is a mediator between attachment and depression. Hyperactivating strategies, in particular, have been consistently noted as mediators for anxious attachment and depressive symptomatology, whereas evidence for deactivating strategies as mediators between avoidant attachment and depressive symptoms has been mixed. Future research should test the mediators of attachment and symptoms and examine theoretically grounded models of psychopathology, such as metacognitive and cognitive models using clinical samples
Observations of radio-quiet quasars at 10-mas resolution by use of gravitational lensing
No full textWe present Very Large Array detections of radio emission in 4 four-image gravitational lens systems with quasar sources: HS 0810+2554, RX J0911+0511, HE 0435−1223 and SDSS J0924+0219, and extended Multi-Element Remote Linked Interferometer (e-MERLIN) observations of two of the systems. The first three are detected at a high level of significance, and SDSS J0924+0219 is detected. HS 0810+2554 is resolved, allowing us for the first time to achieve 10-mas resolution of the source frame in the structure of a radio-quiet quasar. The others are unresolved or marginally resolved. All four objects are among the faintest radio sources yet detected, with intrinsic flux densities in the range 1–5 μJy; such radio objects, if unlensed, will only be observable routinely with the Square Kilometre Array. The observations of HS 0810+2554, which is also detected with e-MERLIN, strongly suggest the presence of a mini active galactic nucleus, with a radio core and milliarcsecond scale jet. The flux densities of the lensed images in all but HE 0435−1223 are consistent with smooth galaxy lens models without the requirement for smaller scale substructure in the model, although some interesting anomalies are seen between optical and radio flux densities. These are probably due to microlensing effects in the optical
Optimizing the mass-specific activity of bilirubin oxidase adlayers through combined electrochemical quartz crystal microbalance and dual polarization interferometry analyses
No full textTwo surface analysis techniques, dual polarization interferometry (DPI) and analysis by an electrochemical quartz crystal microbalance with dissipation capability (E-QCM-D), were paired to find the deposition conditions that give the highest and most stable electrocatalytic activity per adsorbed mass of enzyme. Layers were formed by adsorption from buffered solutions of bilirubin oxidase from Myrothecium verrucaria at pH 6.0 to planar surfaces, under high enzyme loading (≥ 1 mg ml–1) for contact periods up to 2 min. Both unmodified and carboxylate-functionalized gold-coated sensors showed that a deposition solution concentration of between 10–25 mg ml–1 gave the highest activity per mass of adsorbed enzyme with an effective catalytic rate constant (kcat) of about 60 s–1. The densification of adsorbed layers observed by DPI correlated with reduced bioactivity observed by parallel E-QCM-D measurements. Post-adsorption changes in thickness and density observed by DPI were incorporated into Kelvin–Voigt models of the QCM-D response. The modeled response matched experimental observations when the adlayer viscosity tripled after adsorption
Surrendering control, or nothing to lose: Parents’ preferences about participation in a randomised trial of childhood strabismus surgery
No full textStakeholder perceptions of land use for anaerobic digestion, a case study from the United Kingdom
No full textEstablishing task- and modality-dependent dissociations between the semantic and default mode networks.
No full textThe default mode network (DMN) and semantic network (SN) are two of the most extensively studied systems, and both are increasingly used as clinical biomarkers in neurological studies. There are strong theoretical reasons to assume a relationship between the networks, as well as anatomical evidence that they might rely on overlapping cortical regions, such as the anterior temporal lobe (ATL) or angular gyrus (AG). Despite these strong motivations, the relationship between the two systems has received minimal attention. We directly compared the SN and DMN using a large (n = 69) distortion-corrected functional MRI (fMRI) dataset, spanning a range of semantic and nonsemantic tasks that varied input modality. The results showed that both networks fractionate depending on the semantic nature of the task, stimulus type, modality, and task difficulty. Furthermore, despite recent claims that both AG and ATL are semantic hubs, the two areas responded very differently, with results supporting the role of ATL, but not AG, in semantic representation. Specifically, the left ATL was positively activated for all semantic tasks, but deactivated during nonsemantic task performance. In contrast, the left AG was deactivated for all tasks, with the level of deactivation related to task difficulty. Thus, ATL and AG do not share a common interest in semantic tasks, but, rather, a common "disinterest" in nonsemantic tasks. The implications for the variability in the DMN, its cognitive coherence, and interpretation of resting-state fMRI data are discussed
