Naresuan University Journal
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Efficacy of Alteplase ® in a mouse model of acute ischemic stroke: a retrospective pooled analysis
No full textBackground and purpose: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation, has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large dataset from pre-clinical studies, in order to examine the effects of early versus late administration of intravenous recombinant tissue type plasminogen activator (rt-PA). Methods: We collected data from 26 individual studies from 9 international centers (13 researchers, 716 animals) that compared rt-PA to controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery. Studies were classified into early
Study of the production of and hadrons in collisions and first measurement of the branching fraction
No full text[61] Harmonica Alley, Yokohama
No full textThis exhibition explores Miyakobashi Yokocho in drawings, photographs and text. It reveals previously concealed glimpses into Japan’s changing urban culture. Constructed in 1964, just in time for Tokyo’s Summer Olympics, Miyakobashi Shopping Centre transformed a formerly cluttered black market area into an orderly urban marketplace. Over several decades, courageous women converted Miyakobashi into the vibrant entertainment block it is today. Miyakobashi Yokocho is now home to sixty-one lift-sized spaces: ‘ sunakku ’ (snack bars), frequented by business men, local residents and the occasional tourist alike
The Consequences of Smart Grids for the Business Model of Electricity Firms
No full textSmart grids could revolutionize the electricity sector when they stimulate customer empowerment and allow new players such as ICT firms to participate. A key question is whether electricity firms would either benefit or lose from smart grid deployment, because their established business model might be at risk. This paper seeks to explain under which conditions smart grid deployment will have an enabling or a constraining effect on electricity firms' engagement in business model innovation. Critically reviewing existing studies on smart grids, the paper investigates the consequences of smart grid deployment on each of the elements of the business model: value creation, value delivery, and value capture. The main argument posited is that while there are many reasons to believe that electricity firms will embrace smart grids and innovate their business model to accommodate sustainable energy, there are still many uncertainties related to consumer engagement, government support, and new entrants that might induce them to wait with business model innovation until such uncertainties have been resolved. The paper contributes to the emerging literature on business models for smart grids by not only identifying factors that enable, but also those that inhibit the transition of electricity firms towards sustainable energy. In highlighting electricity firms' reasons to resist smart grid technology, the paper provides a more nuanced picture of the potential of smart grids to disrupt the long-standing business models in the electricity sector
The development and evaluation of airborne in situ N2O and CH4 sampling using a Quantum Cascade Laser Absorption Spectrometer (QCLAS)
No full textSpectroscopic measurements of atmospheric N2O and CH4 mole fractions were made on board the FAAM (Facility for Airborne Atmospheric Measurements) large Atmospheric Research Aircraft. We present details of the mid-IR Aerodyne Research Inc. Quantum Cascade Laser Absorption Spectrometer (QCLAS) employed, including its configuration for airborne sampling, and evaluate its performance over 17 flights conducted during summer 2014. Two different methods of correcting for the influence of water vapour on the spectroscopic retrievals are compared and evaluated. A new in-flight calibration procedure to account for the observed sensitivity of the instrument to ambient pressure changes is described, and its impact on instrument performance is assessed. Test flight data linking this sensitivity to changes in cabin pressure is presented. Total 1σ uncertainties of 1.81 ppb for CH4 and 0.35 ppb for N2O are derived. We report a mean difference in 1 Hz CH4 mole fraction of 2.05 ppb (1σ = 5.85 ppb) between in-flight measurements made using the QCLAS and simultaneous measurements using a previously characterised Los Gatos Research Fast Greenhouse Gas Analyser (FGGA). Finally, a potential case study for the estimation of a regional N2O flux using a mass balance technique is identified, and the method for calculating such an estimate is outlined
การตรวจหายีน homolog ของยีนต้านทานเพลี้ยกระโดดสีน้ำตาล (Bph14) ในข้าวพื้นเมือง ข้าวปลูก และข้าวป่าของไทย
No full text เพลี้ยกระโดดสีน้ำตาลเป็นแมลงศัตรูพืชชนิดหนึ่งที่เข้าทำลายผลผลิตข้าวในทวีปเอเชีย และประเทศไทย ดังนั้นการปลูกข้าวสายพันธุ์ต้านทานต่อเพลี้ยกระโดดสีน้ำตาลเป็นแนวทางหนึ่งที่มีประสิทธิภาพ และลดปัญหาสิ่งแวดล้อม จากการเข้าทำลายของเพลี้ยกระโดดสีน้ำตาลในข้าว ปัจจุบันพบว่ามียีนจำนวน 21 ยีนที่เกี่ยวข้องกับการต้านทานเพลี้ยกระโดดน้ำตาล ซึ่งถูกนำมาใช้ในการปรับปรุงพันธุ์ข้าวกันอย่างแพร่หลาย การวิจัยครั้งนี้มีจุดมุงหมายเพื่อตรวจสอบ conserved (CC-NB-LRR) domains ของยีน Bph14 (FJ941067.1) ในข้าวพื้นเมือง ข้าวปลูก และข้าวป่าของไทย จำนวน 37 สายพันธุ์ ทำการทดลองโดยนำลำดับเบสของยีน Bph14 มาออกแบบไพร์เมอร์ที่จำเพาะสำหรับใช้ตรวจสอบบริเวณ conserved (CC-NB-LRR) domains โดยใช้ปฏิกิริยาพีซีอาร์ ผลการทดลองพบว่าข้าวทั้ง 37 สายพันธุ์ ให้ผลิตภัณฑ์พีซีอาร์ขนาด 267 และ 344bp สำหรับ CC- และ NB-domain ซึ่งบ่งชี้ว่าข้าวทุกพันธุ์อาจมี CC- และ NB-domain อยู่ในส่วนของจีโนม นอกจากนี้ผลการทดลองพบอีกว่า ข้าวสายพันธุ์ Swarnalata และ Oryza rufipogon GS.NO. 15157 ให้ผลิตภัณฑ์พีซีอาร์ขนาด 945 สำหรับ LRR-domain ซึ่งบ่งชี้ว่าข้าว 2 สายพันธุ์อาจมี LRR-domain อยู่ในส่วนของจีโนม จากนั้นทำการวิเคราะห์ความเหมือน ของลำดับเบส โดยตัดชิ้นส่วนของ PCR product จากข้าวสายพันธุ์ดังกล่าว แล้วนำมาสกัดดีเอ็นเอออกจากเจลโดยใช้ชุดสำเร็จ จากนั้น ส่งตัวอย่างไปวิเคราะห์ลำดับเบส ผลการทดลองพบว่า สายพันธุ์ข้าวที่ใช้ศึกษามีค่าความเหมือนของลำดับเบสอยู่ในช่วง 93-95 91-98 และ 67.26-84.7% เปอร์เซ็นต์ เมื่อเทียบกับลำดับเบสที่บริเวณ CC- NB- and LRR domains ของยีน Bph14 ตามลำดับ
คำสำคัญ: ข้าว เพลี้ยกระโดดสีน้ำตาล ยีนต้านทานเพลี้ยกระโดดสีน้ำตาล
The brown planthopper (BPH) is one of the major serious insect pests of many rice productions in Asia and Thailand. Growing the BPH-resistant rice varieties is the most effective and environment-friendly strategy for protecting the rice crop from BPH. Nowadays, more than 21 BPH-resistant genes have been reported and utilized in rice breeding programs. Here, the aim of this study is to determine the present of Bph14-homolog gene in native-, cultivated-, wild-, Thai rice (37 varieties). Three conserved (CC-NB-LRR) domains in cds of Bph14 gene sequence (accession number: FJ941067.1) had been designed the specific primers to identify of these domains in these rice varieties by using PCR technique. Results showed that the right DNA bands of CC- and NB-domains were expected to be approximately 267bp and 344 bp respectively in all 37 rice varieties. Moreover, two of these rice verities (Swarnalata and Oryza rufipogon GS.NO. 15157) gave the right DNA bands of LRR-domain which was expected to be approximately 945bp. The areas of the gel track corresponding to these sizes were excised, and the DNA fragments in the gel were purified with QIAquick Gel Extraction Kit Protocol, and then purified-DNA fragments were sequenced. The results found that nucleotide sequences of CC-and NB-domains gave 93-95, 91-98 and 67.26-84.7% percentage of homologies with corresponding regions in CC-, NB- and LRR domains of Bph14 gene respectively.
Keywords: Oryza sativa L., brown planthopper, Bph14 gen
Dimensional Analysis of Shear Stress of Blood Flow through a Bifurcation: Skin Friction Coefficients
No full text The purpose of the current work is to numerically study blood flow through a bifurcation in a model by using the finite element method. The calculated results are reported in terms of velocity contours, wall shear stress and skin coefficients for specific locations during a pulse cycle such as the peak systole and the diastole, for which the corresponding Reynolds numbers are 750 and 300, respectively. Three types of fluids were examined: blood using the Carreau-Yasuda model, water and air. The shapes of the wall shear stress and skin friction coefficient distributions were similar in all fluid types. However, values of skin friction coefficients for the three fluids were similar, and gave much lower percentage differences between the blood and both Newtonian fluids than wall shear stress values.
Keywords: Bifurcation, Carreau-Yasuda, Dimensional Analysis, Skin Friction Coefficient, non-Newtonia
