Naresuan University Journal
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An investigation of diffusion-mediated cyclic coarsening and reversal coarsening in an advanced Ni-based superalloy
No full textThe anomalous cyclic coarsening behaviour of γ′ precipitates after ageing at 1073 K has been investigated for the low misfit commercial powder metallurgy (PM) Ni-based superalloy RR1000. Using scanning transmission electron microscope (STEM) imaging combined with absorption-corrected energy-dispersive X-ray (EDX) spectroscopy, the elemental segregation as a function of coarsening behaviour has been experimentally observed for secondary γ′ precipitates. Elemental EDX spectrum imaging has revealed nanoscale enrichment of Co and Cr and a depletion of Al and Ti within the γ matrix close to the γ-γ′ interface. Our experimental results, coupled with complementary modelling and synchrotron X-ray diffraction analysis, demonstrate the importance of elastic strain energy resulting from local compositional variations for influencing precipitate morphology. In particular, elemental inhomogeneities, as a result of complex diffusive interactions within both matrix and precipitates, play a crucial role in determining the rate of coarsening. Our findings provide important new evidence for understanding the microstructural evolution observed for advanced superalloys when they are exposed to different heat treatment regimes.</p
Distress in relation to attenuated psychotic symptoms in the ultra high risk population is not associated with increased risk of psychotic disorder
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Beyond Acquisition: Exploring energy consumption through the appreciation and appropriation of domestic lighting in the UK
No full textPost-Transplant Lymphoproliferative Disorder in Adult Renal Transplant Recipients: Survival and Prognosis.
No full textPost-transplant lymphoproliferative disorder (PTLD) is a rare, serious complication following solid organ transplantation, with an incidence of 2.6 cases per 1000 patient years. Optimal treatment strategies and risk stratifications specific to kidney transplantation are lacking, and PTLD mortality remains high. We investigated survival and prognosis in 89 cases of PTLD presenting over 44 years at Manchester Royal Infirmary. Patient survival following diagnosis was 72% at 6 months, 67% at 1 year, and 54% at 3 years. In multivariate analysis a poorer 3 year survival associated with acute kidney injury at diagnosis (p=0.0001), impaired renal function (p=0.04), early onset (p=0.02), T cell disease (p=0.02), and previous treatment with anti-thymocyte globulin (p=0.04). The inclusion of graft function adds prognostic value to risk stratification and should be explored further. Strategies to improve survival should include timing and choice of immuno-chemotherapy, preparation for dialysis, and aggressive surveillance for sepsis and treatment toxicity
Knowing what and where: TMS evidence for the dual neural basis of geographical knowledge
No full textSpondyloenchondrodysplasia due to mutations in ACP5: A comprehensive survey.
No full textPURPOSE: Spondyloenchondrodysplasia is a rare immuno-osseous dysplasia caused by biallelic mutations in ACP5. We aimed to provide a survey of the skeletal, neurological and immune manifestations of this disease in a cohort of molecularly confirmed cases. METHODS: We compiled clinical, genetic and serological data from a total of 26 patients from 18 pedigrees, all with biallelic ACP5 mutations. RESULTS: We observed a variability in skeletal, neurological and immune phenotypes, which was sometimes marked even between affected siblings. In total, 22 of 26 patients manifested autoimmune disease, most frequently autoimmune thrombocytopenia and systemic lupus erythematosus. Four patients were considered to demonstrate no clinical autoimmune disease, although two were positive for autoantibodies. In the majority of patients tested we detected upregulated expression of interferon-stimulated genes (ISGs), in keeping with the autoimmune phenotype and the likely immune-regulatory function of the deficient protein tartrate resistant acid phosphatase (TRAP). Two mutation positive patients did not demonstrate an upregulation of ISGs, including one patient with significant autoimmune disease controlled by immunosuppressive therapy. CONCLUSIONS: Our data expand the known phenotype of SPENCD. We propose that the OMIM differentiation between spondyloenchondrodysplasia and spondyloenchondrodysplasia with immune dysregulation is no longer appropriate, since the molecular evidence that we provide suggests that these phenotypes represent a continuum of the same disorder. In addition, the absence of an interferon signature following immunomodulatory treatments in a patient with significant autoimmune disease may indicate a therapeutic response important for the immune manifestations of spondyloenchondrodysplasia
A facile post-synthetic modification method to improve hydrothermal stability and CO2 selectivity of CuBTC metal-organic framework
No full textPractical applications require hydrothermally stable metal-organic frameworks (MOFs). Achieving stable MOFs in the presence of water or humidity is challenging, especially for MOFs with open metals sites (OMSs) due to the high affinity of water molecules towards OMSs. A straightforward solution to tackling this problem is to protect OMSs in the porous structure of MOFs. A facile post-synthetic modification (PSM) method for the synthesis of molecular glycine-doped CuBTC MOF (BTC = benzene-1,3,5-tricarboxylic acid) was developed in this study. Developed materials, i.e. Gly-CuBTC MOFs, were characterized using various characterization techniques and evaluated using single-component gas (CO2 and N2) adsorption and dynamic water vapor adsorption experiments. The economical dopant of molecular glycine with amine and carboxyl group was found to be able to saturate OMSs in the parent CuBTC MOF leading to the improved hydrothermal stability and CO2:N2 selectivity. It was also found that the adsorption capacity, CO2:N2 selectivity and hydrothermal stability of Gly-CuBTC MOFs depend on the percentage of saturation of OMSs in the parent MOF