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Editorial: Insights in Leadership in Education: 2022
Get PDFThis collection of articles provides an overview of educational leadership as we emerge from the pandemic crisis into a divisive era characterized by political unrest, social and cultural upheaval, and persistent economic hardship. Across the globe, leaders in primary, secondary and tertiary institutions are faced with the challenges of making up for student learning loss during the pandemic, educator burn out, parental and community concerns about curriculum content, mental health issues and the impact of artificial intelligence on education. Education leaders are taxed with meeting these challenges with scant resources in a conservative policy climate that favors traditionalism at the expense of a liberal progressive outlook
Group 14 Metallocene Catalysts for Carbonyl Hydroboration and Cyanosilylation
Get PDFA series of six Group 14 metallocene compounds (M = Ge, Sn, Pb) were studied as catalysts for carbonyl hydroboration and cyanosilylation reactions at room temperature. Both bis(pentamethylcyclopentadienyl) and tetramethyldisiloxa[3]metallocenophane compounds were compared. The tin and lead metallocenophanes exhibited the highest reactivity in hydroboration and cyanosilylation reactions. Hammett analysis of aldehyde hydroboration provided a ρ value of 0.73, suggesting a buildup of negative charge during the turnover-limiting step, consistent with the transition state for hydride transfer to the carbonyl center. NMR studies of Lewis acidity indicate that the Ge, Sn, and Pb tetramethyldisiloxa[3]metallocenophane compounds are weak Lewis acids
Overcoming the Barriers to Teaching Teamwork to Undergraduates in STEM
Get PDFThere is widespread recognition that undergraduate students in the life sciences must learn how to work in teams. However, instructors who wish to incorporate teamwork into their classrooms rarely have formal training in how to teach teamwork. This is further complicated by the application of synonymous and often ambiguous terminology regarding teamwork that is found in literature spread among many different disciplines. There are significant barriers for instructors wishing to identify and implement best practices. We synthesize key concepts in teamwork by considering the knowledge, skills, and attitudes (KSAs) necessary for success, the pedagogies and curricula for teaching those KSAs, and the instruments available for evaluating and assessing success. There are only a limited number of studies on teamwork in higher education that present an intervention with a control group and a formal evaluation or assessment. Moreover, these studies are almost exclusively outside STEM disciplines, raising questions about their extensibility. We conclude by considering how to build an evidence base for instruction that will empower students with the KSAs necessary for participating in a lifetime of equitable and inclusive teamwork
Ground Electric Field, Atmospheric Weather and Electric Grid Variations in Northeast Greece Influenced by the March 2012 Solar Activity and the Moderate to Intense Geomagnetic Storms
Get PDFIn a recent paper, we extended a previous study on the solar solar influence to the generation of the March 2012 heatwave in the northeastern USA. In the present study we check the possible relationship of solar activity with the early March 2012 bad weather in northeast Thrace, Greece. To this end, we examined data from various remote sensing instrumentation monitoring the Sun (SDO satellite), Interplanetary space (ACE satellite), the Earth’s magnetosphere (Earth-based measurements, NOAA-19 satellite), the top of the clouds (Terra and Aqua satellites), and the near ground atmosphere. Our comparative data analysis suggests that: (i) the winter-like weather (rainfall, fast winds, decreased temperature) in Thrace started on 6 March 2012, the same day as the heatwave started in USA, (ii) during the March 2012 winter-like event in Thrace (6–15 March), the ACE satellite recorded enhanced fluxes of solar energetic particles (SEPs), while SOHO and PAMELA recorded solar protons at very high energies (\u3e500 MeV), (iii) Between 3–31 March, the temperature in Alexandoupoli and the ACE/EPAM solar high energy (1.88–4.70 MeV) proton flux were strongly anticorelated (r = −0.75, p = 0.5). (iv) Thrace experienced particularly intense cyclonic circulation, during periods of magnetic storms on 8–10 and 12–13 March, which occurred after the arrival at ACE of two interplanetary shock waves, on March 8 and March 11, respectively, (v) at the beginning of the two above mentioned periods large atmospheric electric fields were recorded, with values ranging between ~−2000 V/m and ~1800 V/m on 8 March, (vi) the winter-like weather on 8–10 March 2012 occurred after the detection of the main SEP event related with a coronal mass ejection released in interplanetary space as a result of intense solar flare activity observed by SDO on 7 March 2012, (vi) the 8–10 March weather was related with a deep drop of ~63 °C in the cloud top temperature measured by MODIS/Terra, which favors strong precipitation. Finally, we analyzed data from the electric power network in Thrace (~41°N) and we found, for the first time sudden voltage changes of ~3.5 kV in the electric grid in Greece, during the decay phase of the March 2012 storm series. We discuss the winter-like March 2012 event in Thrace regarding the influence of solar cosmic rays on the low troposphere mediated by positive North Atlantic Oscillation (NAO). Finally, we infer that the novel finding of the geomagnetic effects on the electric power grid in Thrace may open a new window into space weather applications research
Ordinaries 14: Biological Economics
No full textThe Ordinaries column began in 2019 to promote a Neo-Darwinian synthesis of neoclassical and behavioral economics. In this, the last Ordinaries article, the goal remains to improve economics by utilizing natural science theory and methodologies to improve economics
Taming the Cytokine Storm: Small Molecule Inhibitors Targeting IL-6/IL-6α Receptor
No full textGiven the increasing effectiveness of immune-based therapies, management of their associated toxicities is of utmost importance. Cytokine release syndrome (CRS), characterized by elevated levels of cytokine, poses a significant challenge following the administration of antibodies and CAR-T cell therapies. CRS also contributes to multiple organ dysfunction in severe viral infections, notably in COVID-19. Given the pivotal role of IL-6 cytokine in initiating CRS, it has been considered a most potential therapeutic target to mitigate hyperactivated immune responses. While monoclonal antibodies of IL-6 show promise in mitigating cytokine storm, concerns about immunotoxicity persist, and small molecule IL-6 antagonists remain unavailable. The present study employed sophisticated computational techniques to identify potential hit compounds as IL-6 inhibitors, with the aim of inhibiting IL-6/IL-6R protein–protein interactions. Through ligand-based pharmacophore mapping and shape similarity in combination with docking-based screening, we identified nine hit compounds with diverse chemical scaffolds as potential binders of IL-6. Further, the MD simulation of 300 ns of five virtual hits in a complex with IL-6 was employed to study the dynamic behavior. To provide a more precise prediction, binding free energy was also estimated. The identified compounds persistently interacted with the residues lining the binding site of the IL-6 protein. These compounds displayed low binding energy during MMPBSA calculations, substantiating their strong association with IL-6. This study suggests promising scaffolds as potential inhibitors of IL-6/IL-6R protein–protein interactions and provides direction for lead optimization