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Measurement Time of Weak Measurements on Large Entangled Systems
Get PDFIt is well established that starting only with strong, projective quantum measurements, experiments can be designed to allow weak measurements, which lead to a random walk between the possible final measurement outcomes. However, one can ask the reverse question: starting with only weak measurements, can all the results of standard strong measurements be recovered? Prior work has shown that some results can be, such as the Born rule for the probability of measurement outcomes as a function of wave intensity. In this paper, we show that another crucial result can be reproduced by purely weak measurements, namely, the collapse of a many-body, nonlocally entangled wave function on a timescale comparable to the characteristic time of a single, local measurement. For an entangled state of a single excitation among qubits, we find the collapse time scales as a double logarithm of . This result affirms the self-consistency of the hypothesis that spontaneous weak measurements lie at the base of all physical measurements, independent of human observers
The Limitation Effect: Florida Restrictions as a National Warning Sign
Get PDFThe abstract below summarizes a white paper report we released in fall 2024, The Limitation Effect: Experiences of State Policy-Driven Education Restriction in Florida’s Public Schools (Pollock & Yoshikawa, et al.,). We hope readers will read our report in full. It links to an archive of background information and full interview highlights, as well.
At this writing, the nation has experienced over four years of a divisive networked campaign to restrict how educators can support students in public schools. This campaign has promoted both state law and nationally networked local agitation demanding that public schools limit access to specific realms of ideas, perspectives, information, support, and belonging activities related to the nation’s inequality and diversity. Fueled by conservative/right-wing organizations, politicians, and media characterizing and caricaturing educators’ work as “woke,” “radical left” “indoctrination” “infecting” public schools and harming children, this “conflict campaign” (Pollock et al., Citation2022) has inflamed differences of opinion into demands to “ban,” riling up some Americans to demand that public school educators limit K12 exposure to perspectives, information, and supports related to race, racism, racial inequality, sex, gender/gender identity, and LGBTQ+ existence (in addition to any content deemed “sexual”). Loud voices in this movement have caricatured, imagined, and targeted public schools as flawed institutions supposedly forcing “wokeness,” harming “whites” through diversity, equity, and inclusion efforts, forcing LGBTQ inclusion, even “sexualizing” children, and abridging “parental rights,” and sought to restrict education through two predominant mechanisms: state policy and nationally networked local agitation.
Florida is now the test case for policy mechanisms that leaders in—and tapped for—the Trump administration have also advocated and appear to want implemented and pressured nationwide. Florida offers the nation’s most “advanced” example of how mechanisms of state policy threat are being used to limit K12 learning, teaching, and student support efforts related to the nation’s diversity and inequality and to align schooling for all with restrictive ideologies. While many states have implemented education restriction policies since the 2020–2021 school year, Florida has passed the most such policies in the nation in this time frame and combines the most restriction mechanisms in one place. As such, we view Florida as a national warning sign. In The Limitation Effect, we analyze educator, parent, and student experiences of these state policies in Florida, focusing specifically on policies directly trying to restrict K12 teaching and learning. The key findings and implications of the study are summarized in the abstract below.
Our study shows how policymakers pushing review and “bans” of disliked and imagined K12 efforts to support students can end up hurting everyone
CPEC in the Shadows of Fifth Generation Warfare and the Dynamics of Propaganda Model
Get PDFPurpose – The clear patterns of bias and propaganda such as narrative framing and selective reporting are severely affecting the public opinion and policymakers. Overall, the study shows that media depiction of CPEC conditioned by the propagandistic model and 5GW strategies carries deep meanings for global politics. In addition, there is the necessity to increase media literacy and strategic communication so as to direct the complications of these projects. Transparency and international cooperation become important for regional stability as well as informed public discourse.
Design/methodology/approach – The qualitative analysis of media content is carried out for this research across the various geopolitical regions about the interpretation of CPEC. It is also supplemented with extensive literature review and expert opinions. Thereby, providing a comprehensive view of the media landscape and the underlying narratives about CPEC.
Findings – The findings analyzed the variations in CPEC’s portrayal dominated by factors like media ownership, funding and geopolitical agendas.
Originality/value– This study uniquely integrates CPEC, 5GW and the Propaganda Model, highlighting media-driven narrative warfare’s impact on public perception, policymaking and geopolitical stability, offering fresh insights into strategic communication and information operations
6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a Superagonist for the Intermediate-conductance Ca\u3csup\u3e2+\u3c/sup\u3e-activated K\u3csup\u3e+\u3c/sup\u3e Channel K\u3csub\u3eCa\u3c/sub\u3e3.1
Get PDFNS309 (6,7-dichloro-1H-indole-2,3-dione-3-oxime) is widely used as a pharmacological tool to increase the activity of small- and intermediate-conductance calcium-activated potassium channels. NS309 is assumed to function as a positive allosteric gating modulator. However, its binding site and the molecular details of its action remain unknown. Here, we show that NS309 has a profound effect on the calcium-dependent gating of the intermediate-conductance Ca2+-activated K+ channel KCa3.1. In inside-out experiments, 10 μM NS309 shifted the calcium EC50 from 430 to 31 nM. In whole-cell experiments, changing free intracellular calcium from 250 nM to 3 μM decreased the EC50 of NS309 from 74 to 8.6 nM. We further observed that NS309 could elicit greater responses than saturating calcium, making it a “superagonist.” Molecular modeling suggested 2 possible binding sites for NS309 in KCa3.1, which we probed by mutagenesis and determined that NS309 is binding in the interface between the S45A segment of the intracellular S4–S5 linker and the N-lobe of the channel-associated calmodulin. Molecular dynamic simulations revealed that NS309 pushes several water molecules out of the interface pocket, establishes stable contacts with S181 and L185 in the S45A segment of KCa3.1 and E54 in calmodulin, and promotes longer sustained widening of the inner gate of KCa3.1 at V282 in the S6 segment. Polar substitutions of the hydrophobic-gating residues V282 and A279 resulted in constitutively open channels that could not be further potentiated by NS309, suggesting that NS309 produces its agonistic effects by increasing the open probability of the inner gate of KCa3.1. Significance Statement
The publication of the full-length cryo-electron microscopy structure of the intermediate-conductance Ca2+-activated K+ channel KCa3.1 suggested that the previously reported binding site of NS309 (6,7-dichloro-1H-indole-2,3-dione-3-oxime) was a crystallization artifact because this structure only included the C-terminus and the channel-associated calmodulin. This study demonstrates that the true binding site of NS309 is located between the S4 and S5 linker of KCa3.1 and the N-lobe of calmodulin. NS309 acts as a stabilizing force within the gating interface and increases the open probability of the inner hydrophobic gate
DanZens: A Toolkit for Sensing, Labeling and Visualizing Dance Movements
No full textWearable technology offers new opportunities for analyzing complex movements like dance, where precision, coordination, and feedback are key. In this demo, we present DanZens, a novel toolkit for real-time motion analysis in dance, leveraging wearable sensors to provide accessible and actionable feedback. Combining DanceTag to capture and annotate movements with DanceVis to visualize performance differences, DanZens uses Sony Mocopi sensors to analyze motion and generate intuitive heat maps through Dynamic Time Warping (DTW). This system enables precise, cost-effective comparisons between two people doing dance-related movements, offering personalized feedback and eliminating the need for expensive biomechanical labs. Designed to advance pervasive computing in interactive and creative domains, DanZens demonstrates the potential of wearable technology to transform movement analysis and learning experiences
ParentCoach: Designing an mHealth Parenting App to Enhance Parental Involvement in ADHD Support
No full textIntroduction: Parents play a vital role in supporting self-regulation and managing behaviors in children with Attention-Deficit/Hyperactivity Disorder (ADHD). However, many face barriers to accessing consistent, evidence-based support. Mobile health (mHealth) technologies offer a promising way to deliver flexible, low-burden guidance for parents on best practices and strategies to support their children\u27s self-regulation. However, designing them is non-trivial.
Objective: This paper introduces ParentCoach, a mobile application designed to support parents of children with ADHD through brief daily lessons, reflection prompts, and skill-building activities.
Methods: ParentCoach was developed in two phases: (1) secondary analysis of qualitative data from over 30 families using mHealth tools to support self-regulation, and (2) co-design with ADHD experts to refine and validate the curriculum.
Results: Our findings identify key design needs for digital parenting tools: micro-interactions, flexible content formats, scaffolding for executive function, and emotional reflection. The resulting app delivers an 80-lesson curriculum across 16 weekly themes covering relational self-reflection, emotional regulation, communication, and behavior management.
Discussion: ParentCoach design and development show how evidence-based parenting strategies can be translated into accessible, scalable mHealth interventions. Our study offers key design implications for digital tools that support parent learning, emotional resilience, and behavioral consistency in the home. Currently, we are running a randomized controlled trial to provide evidence of ParentCoach\u27s impact. This work contributes to ongoing efforts to develop technology-enhanced behavioral interventions for families of children with ADHD
Guide for Selecting Experimental Models to Study Dietary Fat Absorption
No full textDietary fat absorption is a complex, multi-step process involving digestion, enterocyte uptake, intracellular trafficking, re-esterification, and transport via lipoproteins into circulation. Because dietary fat absorption plays a central role in lipid homeostasis, metabolic syndrome, and fat malabsorption disorders, its study has a broad biomedical significance. However, experimental investigation of this process is technically challenging due to the short lifespan of enterocytes, the dual lymphatic and portal transport routes, and the need to trace the metabolic fate of absorbed lipids. This review summarizes and critically evaluates the major experimental systems used to study dietary fat absorption, highlighting their respective strengths, limitations, and utility. A guide for selecting the most appropriate model to study specific stages of dietary fat absorption is also presented. Ultimately, because each model carries inherent methodological constraints, integrative experimental strategies that combine complementary will be necessary to link mechanistic insights with physiological relevance