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How to Engage with the Media and Expand the Impact of Your Work
No full textAcademic scholars are generally not trained to write for broad audiences, so how do you get your compelling, newsworthy research out there? Gregory R. Goldsmith offers five considerations
Oxidative Stress and Ion Channels in Neurodegenerative Diseases
Get PDFNumerous neurodegenerative diseases result from altered ion channel function and mutations. The intracellular redox status can significantly alter the gating characteristics of ion channels. Abundant neurodegenerative diseases associated with oxidative stress have been documented, including Parkinson’s, Alzheimer’s, spinocerebellar ataxia, amyotrophic lateral sclerosis, and Huntington’s disease. Reactive oxygen and nitrogen species compounds trigger posttranslational alterations that target specific sites within the subunits responsible for channel assembly. These alterations include the adjustment of cysteine residues through redox reactions induced by reactive oxygen species (ROS), nitration, and S-nitrosylation assisted by nitric oxide of tyrosine residues through peroxynitrite. Several ion channels have been directly investigated for their functional responses to oxidizing agents and oxidative stress. This review primarily explores the relationship and potential links between oxidative stress and ion channels in neurodegenerative conditions, such as cerebellar ataxias and Parkinson’s disease. The potential correlation between oxidative stress and ion channels could hold promise for developing innovative therapies for common neurodegenerative diseases
Wilms’ Tumor 1 (WT1) Antigen is Overexpressed in Kaposi Sarcoma and is Regulated by KSHV vFLIP
Get PDFIn people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS herpesvirus (KSHV/HHV-8), remains one of the most common malignancies worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may present with extensive disease requiring chemotherapy. Hence, new therapeutic approaches are needed. The Wilms’ tumor 1 (WT1) protein is overexpressed and associated with poor prognosis in several hematologic and solid malignancies and has shown promise as an immunotherapeutic target. We found that WT1 was overexpressed in \u3e90% of a total 333 KS biopsies, as determined by immunohistochemistry and image analysis. Our largest cohort from ACTG, consisting of 294 cases was further analyzed demonstrating higher WT1 expression was associated with more advanced histopathologic subtypes. There was a positive correlation between the proportion of infected cells within KS tissues, assessed by expression of the KSHV-encoded latency-associated nuclear antigen (LANA), and WT1 positivity. Areas with high WT1 expression showed sparse T-cell infiltrates, consistent with an immune evasive tumor microenvironment. We show that major oncogenic isoforms of WT1 are overexpressed in primary KS tissue and observed WT1 upregulation upon de novo infection of endothelial cells with KSHV. KSHV latent viral FLICE-inhibitory protein (vFLIP) upregulated total and major isoforms of WT1, but upregulation was not seen after expression of mutant vFLIP that is unable to bind IKKƴ and induce NFκB. siRNA targeting of WT1 in latent KSHV infection resulted in decreased total cell number and pAKT, BCL2 and LANA protein expression. Finally, we show that ESK-1, a T cell receptor–like monoclonal antibody that recognizes WT1 peptides presented on MHC HLA-A0201, demonstrates increased binding to endothelial cells after KSHV infection or induction of vFLIP expression. We propose that oncogenic isoforms of WT1 are upregulated by KSHV to promote tumorigenesis and immunotherapy directed against WT1 may be an approach for KS treatment
Spacetime Geometry of Acoustics and Electromagnetism
Get PDFBoth acoustics and electromagnetism represent measurable fields in terms of dynamical potential fields. Electromagnetic force-fields form a spacetime bivector that is represented by a dynamical energy–momentum 4-vector potential field. Acoustic pressure and velocity fields form an energy–momentum density 4-vector field that is represented by a dynamical action scalar potential field. Surprisingly, standard field theory analyses of spin angular momentum based on these traditional potential representations contradict recent experiments, which motivates a careful reassessment of both theories. We analyze extensions of both theories that use the full geometric structure of spacetime to respect essential symmetries enforced by vacuum wave propagation. The resulting extensions are geometrically complete and phase-invariant (i.e., dual-symmetric) formulations that span all five grades of spacetime, with dynamical potentials and measurable fields spanning complementary grades that are related by a spacetime vector derivative (i.e., the quantum Dirac operator). These complete representations correct the equations of motion, energy–momentum tensors, forces experienced by probes, Lagrangian densities, and allowed gauge freedoms, while making manifest the deep structural connections to relativistic quantum field theories. Finally, we discuss the implications of these corrections to experimental tests
Keynote Address: Copyrighting All the Melodies to Avoid Accidental Infringement
No full textDamien Riehl, Attorney and Founder of All the Music, LL
Bibliography for Pubcrawl: Stacy Russo Display
Get PDFA bibliography created to accompany a display about Stacy Russo during April 2024 at the Leatherby Libraries at Chapman University, to support the annual Literary Pub(lishing) Crawl event hosted each year by the Department of English and the Leatherby Libraries
World Autism Month: A Digital Library Display
No full textApril marks World Autism Month, commencing with the observance of World Autism Awareness Day on April 2nd, as adopted by the United Nations in 2007. This day is an annual opportunity to promote advocacy, acceptance, and appreciation for the rights and well-being of those on the autism spectrum and foster a society that values neurodiversity.[1] This display is part of the Leatherby Libraries\u27 Diversity, Equity and Inclusion initiatives in alignment with the Chapman University Strategic Plan for Diversity & Inclusion, fostering a diverse and inclusive campus climate