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Biomaterials
Full text linkGlobally, there are 20 million adolescent girls and young women living with HIV who have limited access to long-acting, effective, women-controlled preventative methods. Additionally, although there are many contraceptive methods available, globally, half of all pregnancies remain unintended. Here we report the first 3D-printed multipurpose prevention technology (MPT) intravaginal ring (IVR) for HIV prevention and contraception. We utilized continuous liquid interface production (CLIP\u2122) to fabricate MPT IVRs in a biocompatible silicone-based resin. Etonogestrel (ENG), ethinyl estradiol (EE), and islatravir (ISL) were loaded into the silicone poly(urethane) IVR in a controlled single step drug loading process driven by absorption. ENG/EE/ISL IVR promoted sustained release of drugs for 150 days in vitro and 14 days in sheep. There were no adverse MPT IVR-related findings of cervicovaginal toxicity or changes in vaginal biopsies or microbiome community profiles evaluated in sheep. Furthermore, ISL IVR in macaques promoted sustained release for 28 days with ISL-triphosphate levels above the established pharmacokinetic benchmark of 50-100 fmol/10| PBMCs. The ISL IVR was found to be safe and well tolerated in the macaques with no observed mucosal cytokine changes or alterations in peripheral CD4 T-cell populations. Collectively, the proposed MPT IVR has potential to expand preventative choices for young women and girls.R01 AI150358/AI/NIAID NIH HHSUnited States/CC999999/ImCDC/Intramural CDC HHSUnited States/R01 AI162246/AI/NIAID NIH HHSUnited States/R01 AI176949/AI/NIAID NIH HHSUnited States/R61 AI136002/AI/NIAID NIH HHSUnited States
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No full text2008 Costa Rica (Ages 13-15) Global Youth Tobacco Survey (GYTS) Fact Shee
2005 Mexico - Monterrey (Ages 13-15) Global Youth Tobacco Survey (GYTS) Fact Sheet
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2003 Georgia (Ages 13-15) Global Youth Tobacco Survey (GYTS) Fact Sheet
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2000 Palau (Ages 13-15) Global Youth Tobacco Survey (GYTS) Fact Sheet
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2007 Zambia - Chongwe-Luangwa (Ages 13-15) Global Youth Tobacco Survey (GYTS) Fact Sheet
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