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J Oncol Res Ther
Full text linkIntroduction:Immune-related adverse events (irAEs) are a group of autoimmune syndromes that arise following therapy with immune checkpoint inhibitors (ICIs) and are characterized by disinhibition of cell-mediated immunity and decreased self-tolerance. First line treatment of irAEs is typically steroids. Severe irAEs that are refractory to steroids can be life threatening and treatment protocols are an area of unmet need. Standardized clinical guidelines for management of severe corticosteroid refractory irAEs are currently not available and thus are an area of unmet need.Cases:We present two patients who were treated with nivolumab and subsequently developed steroid refractory irAEs in the forms of transverse myelitis, arthritis, and peri-engraftment respiratory distress syndrome.Conclusions:Treatment with a single high dose of cyclophosphamide resulted in rapid and sustained clinical improvements in two patients experiencing steroid refractory irAEs following ICI therapy. Cyclophosphamide may benefit patients with wide spectrum of irAEs while having a favorable toxicity profile.R01 CA275007/CA/NCI NIH HHSUnited States/U01 OH012271/OH/NIOSH CDC HHSUnited States
Dengue virus infections Dengue-like illness: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Dengue virus infections Dengue-like illness cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
COVID-19 Hospital Data Reporting Guidance
No full textReporting Updates to CDC\u2019s National Healthcare Safety Network Post-COVID-19 Public Health Emergenc
Hepatitis B, chronic Probable: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Hepatitis B, chronic Probable cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Syphilis Congenital: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Syphilis Congenital cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Cronobacter invasive infection, infants Confirmed: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Cronobacter invasive infection, infants Confirmed cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Hepatitis A Confirmed: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Hepatitis A Confirmed cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Haemophilus influenzae, invasive disease, Age <5 years, Non-b serotype: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Haemophilus influenzae, invasive disease, Age <5 years, Non-b serotype cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Campylobacteriosis: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Campylobacteriosis cases. The weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov
Vancomycin-intermediate\ua0Staphylococcus aureus: (Week 40) Weekly cases* of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents week ending October 5, 2024
No full textThis data includes weekly cases of notifiable diseases, United States, U.S. Territories, and Non-U.S. Residents, specifically covering Vancomycin-intermediate\ua0Staphylococcus aureus cases. The Weekly data are considered provisional and collected locally due to state, territorial, and local regulations. Healthcare providers, medical labs, and other entities report conditions to public health departments, varying by jurisdiction. Case notifications for national notifiable conditions are voluntarily submitted to CDC. NNDSS data are provisional and subject to change until reconciled with state and territorial providers. Weekly cumulative counts may increase or decrease as updates occur. Finalized annual data often differ from provisional counts. CDC aggregates data for national notifiable diseases and conditions on a weekly and annual basis. To see specific surveillance Case Definitions for this disease, go to: https://ndc.services.cdc.gov