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Dynamic changes in methadone utilisation for opioid use disorder treatment: a retrospective observational study during the COVID-19 pandemic
Get PDFObjectives: Opioid use disorder (OUD) is a major public health concern in the USA, resulting in high rates of overdose and other negative outcomes. Methadone, an OUD treatment, has been shown to be effective in reducing the risk of overdose and improving overall health and quality of life. This study analysed the distribution of methadone for the treatment of OUD across the USA over the past decade and through the COVID-19 pandemic. Design: Retrospective observational study using secondary data analysis of the Drug Enforcement Administration and Medicaid Databases. Setting: USA. Participants: Patients who were dispensed methadone at US opioid treatment programmes (OTPs). Primary and secondary outcome measures: The primary outcomes were the overall pattern in methadone distribution and the number of OTPs in the USA per year. The secondary outcome was Medicaid prescriptions for methadone. Results: Methadone distribution for OUD has expanded significantly over the past decade, with an average state increase of +96.96% from 2010 to 2020. There was a significant increase in overall distribution of methadone to OTP from 2010 to 2020 (+61.00%, p\u3c0.001) and from 2015 to 2020 (+26.22%, p\u3c0.001). However, the distribution to OTPs did not significantly change from 2019 to 2021 (-5.15%, p=0.491). There was considerable state-level variation in methadone prescribing to Medicaid patients with four states having no prescriptions. Conclusions: There have been dynamic changes in methadone distribution for OUD. Furthermore, pronounced variation in methadone distribution among states was observed, with some states having no OTPs or Medicaid coverage. New policies are urgently needed to increase access to methadone treatment, address the opioid epidemic in the USA and reduce overdose deaths
Open Repository @ Binghamton Monthly Additions and Top Downloads - December 2023
Get PDFNewly added work in the Open Repository @ Binghamton (ORB) from 12/1/2023-12/31/2023. Top downloads from same time frame
Red Ocean
Get PDFAlia Halstead is studying an MA in Creative Writing at Birkbeck, University of London, and has fiction published in The Mechanics Institute Review and Lighthouse Weekly. Alia writes and edits for vegan magazine, V-Land UK, and co-hosts a radio show, Curious Talks, on RadioReverb 97.2FM
X CALLS ME BOYPoetry
Get PDFJohn Muellner (he/him) is an LGBT writer from St. Paul, MN. His work can be read in Gertrude Press, Denver Quarterly, New Delta Review, Emerson Review, and elsewhere. He’s currently an MFA candidate in poetry at New York University
February 25, 2021
Get PDFMichael Quattrone (he/him) is the author of Rhinoceroses (New School Chapbook Award, 2006) and of the songs of One River (Wolfe Island Records, 2018). His work is included inThe Best American Erotic Poems and The Incredible Sestina Anthology. Recent poems are forthcoming in New York Quarterly, Poet Lore, and EcoTheo. Michael lives in Tarrytown, New York, where he reads for The Westchester Review and Slapering Hol Press. michaelquattrone.co
Taxidermy
Get PDFKayleigh Norgord is an MFA graduate of the University of California Davis, where she won the Graduate Writing Prize in poetry. Her work has appeared in The Potomac Review and Illumination Journal, among others. Her awards include a Tomales Bay Writing by Writers Fellowship, a Eudora Welty award for best collection, a Celeste Turner Wright Award for poetry, and a Henry Douglas Mackaman Writers award for best short story. She lives in Oakland
Historical Accounts of Forgotten Stone-Heaping Practices on Nineteenth-Century Hill Farms
Get PDFThis article offers a modest contribution to the ongoing debate among archaeologists, Native American cultural authorities, and avocational researchers concerning the historical origins of the stone-heap sites commonly found in New England’s forested hills. The author’s recent review of historical periodicals, mainly newspapers and agricultural journals, yielded many previously unknown references to farmers constructing stone heaps by hand in working fields and pastures. Popular perceptions of this apparently widespread phenomenon varied. While stone heaping provided opportunities for both young and old family members to prove their worth, some ideologically progressive farmers expressed a strong distain for the practice. By the late 19th century, the region’s abundant stone heaps discovered a new value as raw material for large roadbuilding projects and came to symbolize a simpler way of life that had slipped away as the industrial age gained strength. These findings underscore the possibility that some proportion of the stone-heap sites that contemporary stakeholders identify as elements of ceremonial stone landscapes were created by 19th-century farmers for practical reasons
Understanding and mitigating thiaminase activity in silver carp
Get PDFA deficiency of thiamine (vitamin B1), an essential cofactor for enzymes involved in metabolic processes, can be caused by the enzyme thiaminase. Thiaminase in food stocks has been linked to morbidity and mortality due to thiamine depletion in many ecologically and economically important species. Thiaminase activity has been detected in certain bacteria, plants, and fish species, including carp. The invasive silver carp (Hypophthalmichthys molitrix) presents an enormous burden to ecosystems throughout the Mississippi River watershed. Its large biomass and nutritional content offer an attractive possibility as a food source for humans, wild animals, or pets. Additionally, harvesting this fish could alleviate some of the effects of this species on waterways. However, the presence of thiaminase would detract from its value for dietary consumption. Here we confirm the presence of thiaminase in several tissues from silver carp, most notably the viscera, and systematically examine the effects of microwaving, baking, dehydrating, and freeze-drying on thiaminase activity. Certain temperatures and durations of baking and microwaving reduced thiaminase activity to undetectable levels. However, caution should be taken when carp tissue is concentrated by processes without sufficient heat treatment, such as freeze-drying or dehydration, which results in concentration, but not inactivation of the enzyme. The effects of such treatments on the ease of extracting proteins, including thiaminase, and the impact on data interpretation using the 4-nitrothiophenol (4-NTP) thiaminase assay were considered
