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Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease
Get PDFCrohn’s disease (CD) is a presentation of inflammatory bowel disease (IBD) that manifests in childhood and adolescence and involves chronic and severe enterocolitis, immune and gut microbial dysregulation, and other complications. Diet and gut-microbiota-produced metabolites are sources of anti-inflammatories that could ameliorate symptoms. However, questions remain on how IBD influences biogeographic patterns of microbial location and function in the gut, how early life transitional gut communities are affected by IBD and diet interventions, and how disruption to biogeography alters disease mediation by diet components or microbial metabolites. Many studies on diet and IBD use a chemically induced ulcerative colitis model, despite the availability of an immune-modulated CD model. Interleukin-10-knockout (IL-10-KO) mice on a C57BL/6 background, beginning at age 4 or 7 weeks, were fed a control diet or one containing 10% (wt/wt) raw broccoli sprouts, which was high in the sprout-sourced anti-inflammatory sulforaphane. Diets began 7 days prior to, and for 2 weeks after inoculation with Helicobacter hepaticus, which triggers Crohn’s-like symptoms in these immune-impaired mice. The broccoli sprout diet increased sulforaphane in plasma; decreased weight stagnation, fecal blood, and diarrhea associated; and increased microbiota richness in the gut, especially in younger mice. Sprout diets resulted in some anatomically specific bacteria in younger mice and reduced the prevalence and abundance of pathobiont bacteria which trigger inflammation in the IL-10-KO mouse, for example, Escherichia coli and Helicobacter. Overall, the IL-10-KO mouse model is responsive to a raw broccoli sprout diet and represents an opportunity for more diet-host-microbiome research
Torus Knot (3,5) Lake Volta Gaboon Ebony, Figure 2
No full textA (3,5) torus knot made from a 2 x4 x4 block of Lake Volta Gaboon Ebony, and is almost 4 in diameter.https://orb.binghamton.edu/mathematical_sculptures/1658/thumbnail.jp
Commonalities and Differences in Governments’ COVID-19 Public Health Responses Around the World
Get PDFAs the world enters the era of increased frequency of global health crises and natural disasters, with climate change looming as an ever-present threat, how we govern ourselves matters for the ways in which we will live through these difficult times. The authors in this volume provide observations backed by mixed methods of analysis on the many ways in which government organization and political realities affect crisis response and crisis management. In this chapter, we further strengthen the validity of their findings with large N global sample analyses where the timing and stringency of the adoption of public health policies by governments at national and subnational levels is shown to be affected by regime type, political institutions, economic conditions, and conditions of countries’ healthcare sector
Making Time for the Ocean
No full textAna Prundaru lives in Switzerland. Her work recently appeared in Faultline Journal, Sundog Lit and Up the Staircase Quarterly. IG: nomadingart. Portfolio: https://nomadingart.wordpress.co
Keeping Each Other in Check
Get PDFViolet Piper is a writer and camp director living in Brooklyn. She has published essays, poems, and hybrid works in Slate, Olit, Blue Mountain Review, and Reductress
The Relationship Between Dairy Products and Motivation & Resilience
No full text●Consumption of dairy products has been linked to increased motivation and resilience, and better mental health.
●We studied the correlation between dairy consumption and motivation in primarily young adults to examine the relationship between diet and mental toughness.
●How does dairy intake relate to motivation and resilience? Using a short survey, we collected data on the nutritional habits from 152 individuals.
●We did not find a significant correlation between consuming dairy and feelings of motivation and resilience
Meet the ORB
No full textThese are slides from a workshop led by the Digital Scholarship team in April 2023 on the Binghamton institutional repository, the ORB, and incorporating research profiles (ORCiD and Expert Gallery) and Creative Commons licenses
Visualizing drug-induced lipid accumulation in lysosomes of live cancer cells with stimulated Raman imaging
Get PDFThe low pH of the lysosomal compartment often results in sequestration of chemotherapeutic agents that contain positively charged basic functional groups, leading to anti-cancer drug resistance. To visualize drug localization in lysosomes and its influence on lysosomal functions, we synthesize a group of drug-like compounds that contain both a basic functional group and a bisarylbutadiyne (BADY) group as a Raman probe. With quantitative stimulated Raman scattering (SRS) imaging, we validate that the synthesized lysosomotropic (LT) drug analogs show high lysosomal affinity, which can also serve as a photostable lysosome tracker. We find that long-term retention of the LT compounds in lysosomes leads to the increased amount and colocalization of both lipid droplets (LDs) and lysosomes in SKOV3 cells. With hyperspectral SRS imaging, further studies find that the LDs stuck in lysosomes are more saturated than the LDs staying out of the lysosomes, indicating impaired lysosomal lipid metabolism by the LT compounds. These results demonstrate that SRS imaging of the alkyne-based probes is a promising approach to characterizing the lysosomal sequestration of drugs and its influence on cell functions