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Self-Defense in the Face of Genocide: A Comparative Study of the Rwandan Patriotic Front and the March 23 Movement
Get PDFThis paper examines the narratives underpinning two cases of self-defense in response to the threat or occurrence of genocide. It delves into the nuances of two movements: the Rwandan Patriotic Front in Rwanda (RPF) and the March 23 Movement (M23) in the Democratic Republic of Congo. Both movements emerged in response to perceived genocidal threats and adopted self-defense narratives to justify their actions. The paper traces the historical contexts, key actors, and agendas that shaped these movements, highlighting the RPF\u27s evolution from a military group into a dominant political force in Rwanda, and the M23\u27s role in protecting Tutsi communities in eastern Congo. Through this analysis, the paper reveals the continuity of self-defense tactics and narratives from the RPF to the M23, underscoring their shared motivations and strategies. However, it also underscores the complexity of disentangling self-defense claims from other contentious agendas, such as aggressive territorial expansion, human rights abuses, and the pursuit of economic interests, which often raise questions about the legitimacy of these claims. The findings suggest that while the self-defense narratives of the RPF and M23 are rooted in legitimate concerns for ethnic survival, their actions raise ethical questions, particularly regarding the humanitarian consequences and the intertwining of self-defense with personal and political agendas
Connecting the Global Library
No full textIn April 2024, three Binghamton University Librarians presented at a conference in Newry, Northern Ireland (CILIP/LAI Joint Conference). They will present on how global libraries in a regional context can inform librarianship across divides. People, places, and things may be different but library goals and functions are the same wherever you go. They will share their experiences presenting and the connections they made
Combinatorial Anti-Cancer Effect of Polypurine Reverse Hoogsteen Hairpins against KRAS and MYC Targeting in Prostate and Pancreatic Cancer Cell Lines
Get PDFIntroduction: KRAS and MYC are proto-oncogenes that are strictly regulated in healthy cells that have key roles in several processes such as cell growth, proliferation, differentiation, or apoptosis. These genes are tightly interconnected, and their dysregulation can lead to cancer progression. We previously individually targeted these oncogenes using Polypurine Reverse Hoogsteen (PPRH) hairpins, mostly targeting the complementary strand of G-quadruplex-forming sequences. We validated them in vitro in different cancer cell lines with deregulated KRAS and/or MYC. In this work we focused on our understanding of the cooperative dynamics between these oncogenes, by investigating the combined impact of PPRHs targeting KRAS and MYC in pancreatic and prostate cancer cells.
Results: The combinations had a modulatory impact on the expression of both oncogenes, with transcriptional and translational downregulation occurring five days post-treatment. Out of the four tested PPRHs, MYC-targeting PPRHs, especially HpMYC-G4-PR-C directed against the promoter, showed a greater cytotoxic and expression modulation effect. When both KRAS- and MYC-targeting PPRHs were applied in combination, a synergistic reduction in cell viability was observed.
Conclusion: The simultaneous targeting of KRAS and MYC demonstrates efficacy in gene modulation, thus in decreasing cell proliferation and viability
Open Repository @ Binghamton Monthly Additions and Top Downloads - November 2024
Get PDFNewly added work in the Open Repository @ Binghamton (ORB) from 11/1/2024-11/30/2024. Top downloads from same time frame
3D Thermal Mapping the Binghamton University Campus
No full textPresentation of a fused lidar + thermal 3D model of the campus collected summer 2024
Renewal in the Cognitive and Emotional Domains: Comparing Novelty-Facilitated Extinction with Counterconditioning and Extinction
Get PDFThe main file is the ReadMe file, with a dataset and python files added in the additional file section
Japanese-English Translation: Three Poems by Takeuchi Kozo: Death in Winter; To the North Sea; Sunset (「冬に死す」・「「北海に」・「夕焼け」), Translated by Christopher Southward
Get PDFJapanese-English Translation: Three Poems by Takeuchi Kozo: Death in Winter; To the North Sea; Sunset (「冬に死す」・「「北海に」・「夕焼け」), Translated by Christopher Southwar
Graphene Oxide Nanosheets Toxicity in Mice Is Dependent on Protein Corona Composition and Host Immunity
Get PDFTwo-dimension graphene oxide (GO) nanosheets with high and low serum protein binding profiles (high/low hard-bound protein corona/HChigh/low) are used in this study as model materials and screening tools to investigate the underlying roles of the protein corona on nanomaterial toxicities in vivo. We proposed that the in vivo biocompatibility/nanotoxicity of GO is protein corona-dependent and host immunity-dependent. The hypothesis was tested by injecting HChigh/low GO nanosheets in immunocompetent ICR/CD1 and immunodeficient NOD-scid II2rγnull mice and performed histopathological and hematological evaluation studies on days 1 and 14 post-injection. HClow GO induced more severe acute lung injury compared to HChigh GO in both immunocompetent and immunodeficient mice, with the effect being particularly pronounced in immunocompetent animals. Additionally, HClow GO caused more significant liver injury in both types of mice, with immunodeficient mice being more susceptible to its hepatotoxic effects. Moreover, administration of HClow GO resulted in increased hematological toxicity and elevated levels of serum pro-inflammatory cytokines in immunocompromised and immunocompetent mice, respectively. Correlation studies were conducted to explore the impact of distinct protein corona compositions on resulting toxicities in both immunocompetent and immunodeficient mice. This facilitated the identification of consistent patterns, aligning with those observed in vitro, thus indicating a robust in vitro–in vivo correlation. This research will advance our comprehension of how hard corona proteins interact with immune cells, leading to toxicity, and will facilitate the development of improved immune-modulating nanomaterials for therapeutic purposes