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High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy
Get PDFDuchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care due to immunomodulatory/immunosuppressive properties but novel genetic approaches, including exon skipping and gene replacement therapy, are currently being developed. The identification of additional biomarkers to assess DMDrelated inflammatory responses and the potential efficacy of these therapeutic approaches are thus of critical importance. The current study uses RNA sequencing of skeletal muscle from two mdx mouse models to identify high mobility group box 1 (HMGB1) as a candidate biomarker potentially contributing to DMD-related inflammation. HMGB1 protein content was increased in a human iPSC-derived skeletal myocyte model of DMD and microdystrophin treatment decreased HMGB1 back to control levels. In vivo, HMGB1 protein levels were increased in vehicle treated B10-mdx skeletal muscle compared to B10-WT and significantly decreased in B10-mdx animals treated with adeno-associated virus (AAV)-microdystrophin. However, HMGB1 protein levels were not increased in D2-mdx skeletal muscle compared to D2-WT, demonstrating a strain-specific difference in DMDrelated immunopathology
Ceramic Studio Practice | Work Images of Greenware Underway | Southward Ceramics @ Studio Brand New |
No full textImages of new functional and decorative stoneware forms underway by Southward Ceramics @ Studio Brand Ne
Undergraduate Nursing Students’ Simulation Experiences with End-of-Life Care in a Rural Setting: A Scoping Review
Get PDFObjective: The purpose of this scoping review is to provide nurse educators and nurse leaders in practice with the findings on the state of the science surrounding undergraduate nursing education simulation-based experiences focused on end-of-life (EOL) care in rural settings. This scoping review aims to identify undergraduate nursing student experiences with EOL care in the rural setting and identify key simulation-based educational strategies utilized in undergraduate nursing programs to inform educational programs about simulation practices. The outcome of this review is intended to advance nursing education to better prepare future nurses for practice and to develop competence in providing EOL and palliative care for rural populations. Introduction: Simulation offers an additional option for clinical education/training in light of the often-limited availability to practice EOL nursing care in nursing educational training. While the number of hospice services increased in all locations including urban and micropolitan, rural and frontier residents may have increased health disparities due to limited access to hospice and palliative care. Access to hospice and palliative care is especially important as rural populations are often older, have multiple chronic conditions, and have lower incomes compared to urban populations. While hospice services are needed in rural and frontier locations, a shortage of healthcare professionals exists, resulting in symptoms of illness and healthcare goals not addressed. Having a workforce and a rural hospice and palliative care team is necessary to intervene early and prevent complications from disability and chronic illness. Inclusion criteria: Relevant sources are defined as including undergraduate nursing students in the United States, simulation-based experiences with end-of-life care, in rural settings in the United States. Sources that included graduate nursing students or professional nurses, non simulation-type training, urban populations, and settings outside the United States will be excluded. Methods: The search terms “undergraduate nursing education,” “hospice/palliative care,” “simulation,” and “rural” were developed by the authors. The search strategy was developed through consultation with the authors, keywords and terms found within the exemplar articles and corresponding controlled vocabularies of the search databases. The search strategy will be peer-reviewed according to the PRESS guidelines by a health science librarian. The databases are to be chosen by availability of access through the university library and corresponding topic coverage. The following databases were searched in August 2024: PubMed, Embase (Elsevier), Web of Science (Core Collection), CINAHL Ultimate (EBSCO), and HealthSource: Nursing/Academic, ERIC, Education Source Ultimate (EBSCO) by Health Science Librarian (LL). Databases searched on the EBSCO platform: APA PsychINFO, ERIC and Education Source revealed zero results and HealthSource: Nursing/Academic had 1 result; all other results are specified in the following tables. Sources dated between January 2011 and August 2024 will be considered. Only sources published in English will be included. Data Synthesis: Data will be gathered from the available evidence to describe the state of the science surrounding undergraduate nursing education simulation-based experiences focused on end-of-life (EOL) care in rural settings. Conclusions: There is a dearth of literature pertaining to undergraduate nursing student simulation-based experiences with end-of-life care in rural settings in the United States. Educational efforts to bolster this practice area are necessary to meet the needs of an aging population
Harpur Palate Volume 23, Issue 1
Get PDFContributors: Sylvia Fox | Areej Quraishi | O. Edward Ozoma | Andrea Rinard | Hannah Rovska-Strider | Suzanne Manizza Roszak | Amy Monticello | Brianna Pike |Eric Roy | Hibah Shabkhez | Sandra Simonds | Juanjuan Henderson | Ann Wong | Mocong Yuan | Emma Aylor | Erin Bennett | Rhienna Guedry | Caylie Herrmann | Romana Iorga | Paris Jessie | Christen Noel Kauffman | Mercedes Lawry | Donald Pasmore | Anthony Thomas Lombardi | Joseph Radke | Lauren Yarnal
Effects of the Sudden Reduction of Social Enrichment on a Novel Rat Model of Approach Orientation
Get PDFThe goal of the present study was to evaluate the effects of a reduction in social enrichment by measuring behavioral changes in the Elevated Plus Maze (EPM) in male and female rats of High Approach (HAO) and Low Approach Orientation (LAO). The results indicated that at baseline, both total arm entries and open arm entries were affected by Approach Orientation and Sex. The percent change in closed arm entries in female LAO was sensitive to a sudden transition from high to standard social enrichment, whereas those in the female HAO and both male groups were behaviorally unaffected. The female LAO group experiencing the sudden transition from high to standard social enrichment had an increase in percent change of closed arm entries, while their control counterparts who experienced continued enrichment had a decrease. Results suggest that the female LAO rats may translate to a population more sensitive to social stress and thus may be useful in identifying biological markers for predicting vulnerability to sudden changes in social environments
Open Repository @ Binghamton Monthly Additions and Top Downloads - March 2024
Get PDFNewly added work in the Open Repository @ Binghamton (ORB) from 3/1/2024-3/31/2024. Top downloads from same time frame
Inuit Land Use Patterns in the Hopedale Region
Get PDFThis paper presents preliminary insights from an exploratory archaeological survey of the Hopedale region, Nunatsiavut. Despite its continued importance — from the 17th century as an Inuit whaling community — to the late 18th century with one of Labrador’s first Moravian missions, to today as the seat of the Nunatsiavut government, Hopedale has seen relatively little archaeological activity since the 1930s, and most of the islands and bays near the town had never been surveyed. A brief survey in the summer of 2018 recorded nearly 30 prehistoric, historic, and ethnographic sites, affirming the Labrador Inuit Association’s 1977 statement– “Our footprints are everywhere”. The majority of these sites are the remains of short- and long-term summer habitation sites, and speak to the extensive and intensive use of Hopedale’s outer coastal region by Labrador Inuit since the 16th century. Here I explore what this land use meant in terms of Labrador Inuit lifeways and mobility, and the intersection of Inuit and European presences (both transient and permanent) that these spaces represent. I thus demonstrate that, as well as being on the periphery of many worlds, Hopedale has a long history as a nexus of economic and social activity
Forgotten Places in Political Spaces
Get PDFThe way in which many people, perhaps particularly those in secure and affluent circumstances, view their ancestry and heritage, and display it to others, is often a matter of pride. In some contexts, however, the identification of ‘ancestors’ and ‘heritage’ can have critically important - and sometimes dire - political, social and spiritual ramifications. Here we examine examples in which archaeological and/or historical evidence points to a distancing or ‘active forgetting’ of ancestors and places associated with them. The motives for creating these ‘forgotten places’ are diverse and might include a fear of ‘ghosts’ or death, the desire to project a newly constructed or evolved political identity to outsiders or distant relations, as well as social-political and economic need to distance themselves from their ancestors. In this paper we will explore four examples from Indigenous settings in northern and eastern Canada where peripheral, or forgotten, spaces were actively constructed