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THE EFFECT OF EX-ANTE GOVERNMENT RESPONSIBILITY FOR HEALTH ON PUBLIC HEALTH FINANCING IN POST PANDEMIC BUDGETS
Get PDFThis paper investigates how pre-pandemic levels of government responsibility for public health financing influenced post-pandemic health spending across selected OECD countries. Using a combination of descriptive analysis and regression modeling, the study examines changes in public health expenditure per capita between 2019 and 2022, focusing on key variables such as the government’s share of health financing, the Total Pandemic Policy Intensity (PPI) index, and GDP per capita. Findings suggest that while all countries increased health spending post-COVID-19, the scale of change varied significantly based on economic capacity, institutional readiness, and political will. Notably, countries with higher pre-pandemic public health investment and more intense pandemic responses tended to demonstrate stronger budgetary increases, though exceptions reveal the influence of additional contextual factors. The study highlights persistent disparities between high- and low-income nations, emphasizing that fiscal space alone is insufficient without robust governance and sustained public commitment. These results underscore the need for adaptive, transparent, and equitable health financing strategies to build resilient health systems capable of withstanding future crises
Steamed broccoli sprouts diet alleviates inflammatory bowel disease by increasing anti-inflammatory, antioxidant, and gut protective metabolites in an ulcerative colitis mouse model
Get PDFBackground: Broccoli is a cruciferous vegetable rich in bioactive compounds that may be beneficial against inflammatory bowel disease. However, an in-depth annotation and understanding of the metabolites and microbial interactions associated with the broccoli sprouts diet is necessary.
Methods: Specific pathogen-free C57BL/6 mice (male, 6 weeks old) were divided into four treatments: control diet; control diet with 2.5% DSS in water to induce symptoms of ulcerative colitis; 90% control diet plus 10% steamed broccoli sprouts; and 90% control diet/ 10% steamed broccoli sprouts plus 2.5% DSS in drinking water to induce symptoms. DSS treatment was cycled three times, with five days of DSS followed by a recovery period of five days. Mice continued their diets throughout the duration of the study. Fecal samples were collected on day 30 and frozen at -80°Cuntil metabolomic analysis. Liquid chromatography, conducted using high-resolution mass spectrometry (LC-HRMS) was performed using a Waters Synapt G2, time-of-flight (TOF) XEVO. The LCMS metadata was processed in MassLynx, Progenesis QI, mzMine, and Sirius tools. This included the use of built-in search engines to obtain retention time, mass charge ratio, molecular weight, peak intensity, metabolites name, and formula using several libraries.
Results: Over 3,000 fecal metabolites were abundant in the feces of mice, with diet being a significant factor of differentiation (+/-steamed broccoli sprouts) and ulcerative colitis (+/-2.5% DSS) treatment methods. The steamed broccoli sprouts intervention significantly increased the concentrations of beneficial metabolites, such as sulforaphane, short-chain fatty acids, tryptophan, indoles, glutamic acid, and polyphenolic metabolites. A positive correlation with commensal bacteria, Bacteroides spp., Intestinimonas, Oscillibacter, and Lachnospiraceae was found in the gut\u27s colon, colon, cecal,and jejunum regions, and jejunum regions.
Novelty: This study used innovative metabolomic methods to identify dietary and microbial anti-inflammatory, antioxidant, prebiotic, and gut-protective metabolites associated with diets including steamed broccoli sprouts. The research concluded that the diet was effective against ulcerative colitis in mice.
Conclusions: These data suggest that broccoli sprouts may positively affect metabolites and microbial interactions. These benefits include their antioxidant, anti-inflammatory, and gut-protective properties that help with inflammatory bowel disease symptoms
Open Repository @ Binghamton Monthly Additions and Top Downloads - March 2025
Get PDFNewly added work in the Open Repository @ Binghamton (ORB) from 3/1/2025-3/31/2025. Top downloads from same time frame
Open Repository @ Binghamton Monthly Additions and Top Downloads - November 2025
No full textNewly added work in the Open Repository @ Binghamton (ORB) from 11/1/2025-11/30/2025. Top downloads from same time frame
Performance of Piezoelectric and Triboelectric Transducers under Gait Loading for Energy Harvesting and Load Monitoring in Total Knee Replacements
No full textThis study investigates the energy harvesting and sensing capabilities of piezoelectric nanogenerators (PENG) and triboelectric nanogenerators (TENG) for long-term load monitoring in total knee replacement (TKR). Multi-layered polyvinylidene fluoride (PVDF) films and cuboid-patterned silicone rubber embedded with dopamine-coated BaTiO3 particles (SR/BT@PDA) TENG are compared as energy harvesting-based load sensors. Unlike prior studies relying on simplified harmonic loading, this work utilizes physiologically relevant gait cycles covering realistic force ranges to precisely evaluate electrical output, sensitivity, and activity recognition capabilities. Results indicate forward-polarized TENG samples and upward-polarized PVDF layers generate significantly higher outputs, indicating the importance of dipole alignment for enhanced sensor efficiency. The harvesters’ outputs show that the SR/BT@PDA TENG achieves a maximum apparent power output of 6μW at 1.5GΩ, while the PVDF reaches 2.7μW at 200MΩ under normal walking conditions. The SR/BT@PDA TENG outperforms PVDF in energy harvesting, reaching 140V in 26 gait cycles for a 10 nF capacitor and powering 60 LEDs, while PVDF charges the same capacitor to 33V in nearly 19 gait cycles, powering 14 LEDs. The TENG’s micro-cuboid surface patterning and synergistic effects of embedded piezoelectric material (BaTiO3) enhance its output power density, whereas the multi-layered PVDF demonstrates reliable performance under diverse load conditions. Both sensors effectively detect diverse activities, including walking, jogging, and stair climbing. Overall, PVDF provides precise load monitoring by tracking dynamic force profiles, while TENG outperforms in energy harvesting. This study evaluates the potential of integrating TENG and PENG into TKR as energy-harvesting solutions for joint load monitoring without relying on external power sources
