6703 research outputs found
Sort by
How to Submit Your Zine to the ORB!
Get PDFThis zine includes the steps required for students to upload their zines to the ORB\u27s digital library. The slides were put together for Autumn Jacobs\u27 first zine workshop as a Library Research Scholar with information from Caitlin Holton, the administrator of the ORB.https://orb.binghamton.edu/zines/1001/thumbnail.jp
Reply: “Continuing the Chat: How Can We Improve the Performance of an Artificial Intelligence Chatbot in Answering Clinical Infectious Diseases Pharmacotherapy Questions?”
Get PDFAssociation of DMD Gene Variant Classes With Motor Outcomes in a Drug Registration Clinical Trial Setting
Get PDFBackground and Objectives: Duchenne muscular dystrophy (DMD) is caused by pathogenic variants of the DMD gene, leading to the loss of dystrophin. Clinical variability in DMD can complicate interpretation of interventional data in clinical trials. One source of clinical variability is allelic heterogeneity (different pathogenic variants with different effects on dystrophin protein expression). We sought to determine whether gene variant classes in clinical trial participants potentially affect clinical trial data interpretation. Methods: We analyzed 186 vamorolone trial participants with DMD (VBP15-002/003; VBP15-004) who were 4 to steroid-naïve at baseline. We stratified participants into gene variant classes by either variant location in the gene affecting different gene promoters (5′ [Dp427-only] vs 3′ [Dp427+other isoforms]) or residual dystrophin levels (null vs possible non-null [5′ gene variants, exon 44 skippable, splice site]). We evaluated associations with baseline motor outcomes and treatment response (prednisone and vamorolone). Results: Participants with variants in ex63 and downstream (null for Dp427+Dp140+Dp71 protein isoforms) showed poorer baseline motor outcomes for time to stand from supine velocity than those with variants in ex1-44 (Dp427 only). No significant baseline differences were found between likely null and possible non-null variants. Participants with only Dp427 involvement showed significantly better treatment response for the 6-minute walk distance. Most of the comparisons of baseline motor function and treatment response were similar between variant classes. Discussion:The large variation in baseline motor function in young, steroid-naïve patients with DMD is only minimally explained by different gene variant classes. While there is strong literature support for 3′ variants leading to a more severe motor and cognitive DMD phenotype, we found this variant class under-represented in our clinical trials. This suggests that they may fail inclusion criteria (failure to follow commands; poor motor function). Subgroup analyses in DMD clinical trials at a young age range based on gene variant class may not reveal significant differences and would be relatively noninformative
Open Repository @ Binghamton Monthly Additions and Top Downloads - July 2025
Get PDFNewly added work in the Open Repository @ Binghamton (ORB) from 7/1/2025-7/31/2025. Top downloads from same time frame
Chronicling language, gender, and sexuality research through digital text analysis
Get PDFThis project is an exploratory analysis of the field of language, gender, and sexuality using the journal Language in Society, a key publication within the fields of sociolinguistics and linguistic anthropology. Chronicling over 50 years of scholarly research, a corpus of research will be analyzed with digital text analysis methods using Python, including topic modeling and sentiment analysis. The project aims to empirically analyze how a) notions of gender and sexuality are represented in linguistics research b) how language surrounding gender and sexuality is represented, discussed, and challenged through research, and c) how language regarding sexual and gender identity has evolved over the course of the journal’s history and how it mirrors the contemporary global and sociopolitical history of gender and sexuality. Preliminary research has indicated trends in men and women’s conversational differences in the 1970s and 1980s, with trends in non-binary language and sexuality emerging in the 21st century.https://orb.binghamton.edu/library_research_scholars_2025/1001/thumbnail.jp
Uncovering Libraries Instagram Engagement
Get PDFThe Binghamton University Libraries utilizes its Instagram platform to engage its audience to share information regarding its resources and services. Current research suggests elements such as color grading, scenic backgrounds, and maintaining a proper online social media presence affect how Instagram users engage with content. However, additional elements such as audience type and how they engage with content may factor into the Libraries’ reach on their platform. This project seeks to identify how the Libraries Instagram platform can maximize engagement based on their audience needs and identified interaction behavior. A literature review determined that a qualitative survey is the best method for this project due to its practicality, quality of responses, and the greatest possibility of reach. Results of the data collected, correlations of the data set, and recommendations based on the findings will be presented via a poster presentation to be used by the Libraries Administration for future implementation.https://orb.binghamton.edu/library_research_scholars_2025/1002/thumbnail.jp
