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Data related to manuscript: BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice
No full textData related to manuscript: BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice.These data were used to create Figures 1-6.Figure 1 presents the effect of JQ1 on sickness behavior after LPS-evoked systemic inflammation in mice up to 12 h post-injection.Figure 2 presents the effect of JQ1 on cytokine levels in blood serum 3 and 12 h after LPS-evoked systemic inflammation.Figure 3 presents the effect of LPS-evoked systemic inflammation on the level of BET proteins in the murine hippocampus 12 h post-injection.Figure 4 presents the effect of LPS and JQ1 on the expression of inflammation-related genes in hippocampus 3 and 12 h post-injection.Figure 5 presents the effect of JQ1 on Tau level and phosphorylation in the hippocampus 12 h after LPS-evoked systemic inflammation.Figure 6 presents the effect of JQ1 on Amyloid-β level in the hippocampus 12 h after LPS-evoked systemic inflammation.Figure 7 presents the effect of JQ1 on the expression of inflammation-related genes in hippocampus 3 and 12 h post-injection.</p
Environmental Effectiveness of Organizations in Diary Industry in Poland
No full textThe dataset contains data on survey questionnaire related to environmental performance, goals and indicators conducted on the Organizations in the Diary Industry in Poland. The survey was conducted on a sample of n=22 Organizations from Poland that operates in the diary industry.</p
Improving efficiency of vapour phase soldering ovens with pressure and temperature-based process monitoring
No full textDuring vapor phase reflow soldering used in electronics manufacturing, the process control of ovens is usually based on temperature measurements, which can be insufficient due to the saturation differences in the temperature and the vapour concentration. Therefore, the ovens use extended cycle times for process identification to ensure the proper formation of solder joints.Our work offers a solution to eliminate the idle time by investigating the hydrostatic pressure conditions in the process zone. A pressure measurement system was developed for vapour phase soldering ovens, which can monitor the vapour pressure changes by a gauge-type pressure sensor with fused temperature measurement. It works as an IoT-enabled node for data logging and subsequent control.Thermocouples were placed at different points of the VPS tank. The measuring points were located in the heat transfer fluid (TC1), and above the soldering level (TC”). TC1 in the Galden liquid gives status about the temperature of the Galden during the preheating of the oven for soldering. TC2 is used to define the start and the end of the soldering cycle. A measurement probe (tube) was placed in the vapour space and the upper end is connected to a sensor, then the vapour generation causes gauge pressure in the system. This additional pressure is proportional to density and the height of the vapour space.The fusion of the hydrostatic pressure values with the temperature values allowed us to identify and reduce the idle time by approximately 60 s, which is 15–20% of the total soldering cycle time. This increases the oven's yield by 15-20%, reduces the system's power consumption by 15–20%, and reduces time above liquidus of the solder by ~35%.The dataset consists:· the published figures in the article in vectorial format· the original source files of the measurements (temperature and pressure) and the published figures (in SVG format) </p
Wolumetria struktur drogi wzrokowej przy użyciu MRI 7 Tesla u pacjentów ze zwyrodnieniem barwnikowym siatkówki spowodowanym mutacjami w genie RPGR
No full textPliki zawierają pseudozanonimizowane wyniki badania (skany) 7Tesla MRI mózgowia u dwóch pacjentów (RPGR1 i RPGR2) ze zwyrodnieniem barwnikowym siatkówki spowodowanym mutacjami w genie RPGR. Protokół obrazowania MR 7T zawiera sekwencję 3D MT SILENT. Foldery zawierają skany mózgowia zapisane w formacie JPEG.Celem badania jest ilościowe zbadanie struktur mózgu przy użyciu 7 Tesla MRI w obecności utraty wzroku spowodowanej zwyrodnieniem barwnikowym siatkówki (RP) związanym z wariantami patogennymi w genie RPGR. Średnia objętość ciała kolankowatego bocznego (prawe-100 mm3, lewe-96 mm3) i objętość lewego zakrętu językowego (6162 mm3) były znacząco niższe u pacjentów z RPGR w porównaniu z grupą kontrolną (odpowiednio 129 mm3, 125 mm3i 7310 mm3), podczas gdy niektóre regiony mózgu związane z innymi informacjami sensorycznymi, takie jak lewy przesmyk zakrętu obręczy (3690 mm3) i kora śródwęchowa (prawa 1564 mm3, lewa 1734 mm3) były znacząco lub prawie znacząco wyższe w grupie RPGR niż w grupie kontrolnej (odpowiednio 2682 mm3, 960 mm3 i 1030 mm3). Zastosowanie rezonansu magnetycznego 7 Tesla ujawniło liczne nieprawidłowości strukturalne szlaku wzrokowego u pacjentów z RPR związanym z RPGR. Reorganizacja struktur mózgu wykazana u pacjentów z RP związanym z RPGR ujawnia pewien stopień plastyczności w odpowiedzi na utratę wzroku. Odkrycia te mogą pomóc w ulepszeniu strategii diagnostycznych i terapeutycznych dla pacjentów z RP.</p
Removal of diclofenac from selected matrices
No full textThe set of data contains results of application of cold atmospheric pressure plasma on the diclofenac removal from different matrices.The research was carried out within Sonata 15 project (UMO-2019/35/D/ST8/04107) financed by National Science Center (Poland).The set of data contains:raw HPLC-DAD dataTotal Organic Compounds and Total Nitrogen analysesaverage pH valuesaverage conductivity valuesaverage numbers of germinated seedsaverage lenght of sproutsaverage weight of sproutsfor untreated or/and cold atmospheric pressure-plasma-treated diclofenac solutions.</p
Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys
No full textThe poultry industry relies extensively on antibiotics and coccidiostats as essential tools for disease management and productivity enhancement. However, increasing concerns about antimicrobial resistance (AMR) and the toxicological safety of these substances have prompted a deeper examination of their broader impacts on animal and human health. This study investigates the toxicological effects of antibiotics and coccidiostats on the gutbrain axis and microbiota in turkeys, with a particular focus on molecular mechanisms that may influence neurochemical and inflammatory responses. Our findings reveal that enrofloxacin exposure leads to the upregulation of BDNF, suggesting a neuroprotective effect, while monensin treatment significantly increased eEF2 kinase expression, indicative enhanced neuronal activity. In turkeys infected with Avian Pathogenic Escherichia coli (APEC), early administration of doxycycline and monensin significantly upregulated the mTOR/BDNF and Akt/mTOR pathways, along with elevated histamine levels, underscoring their role in inflammatory responses modulation. However, treatments administered at 50 days post-hatch did not significantly alter protein levels, though both enrofloxacin and monensin increased serotonin and dopamine levels, suggesting potential neurotoxicological impacts on mood and cognitive functions. These results highlight the complex interactions between antibiotic use, gut microbiota alterations, and neurochemical pathways, with toxicological implications for environmental pollution and public health. This research provides critical insights into the potential toxic effects of prolonged antibiotic and coccidiostat exposure in poultry production, emphasizing the need for responsible use to mitigate risks to ecosystems and human health.</p
Supplementary data for "Molecular insights into the remarkable thermostability of Ts2631 endolysin" by Karolina Ciemińska, Anna-Karina Kaczorowska, Lukasz Pawel Kozlowski, Tadeusz Kaczorowski, Magdalena Plotka
No full textIn the antibiotic resistance crisis, novel solutions to combat bacterial infections are explored, one of which includes the use of endolysins, enzymes derived from bacteriophages that destroy peptidoglycan, a vital bacterial structure. Of particular interest are endolysins that exhibit exceptional thermostability. An example of such endolysin is Ts2631 from bacteriophage vB_Tsc2631 infecting extremophile Thermus scotoductus. The Ts2631 endolysin melting temperature, representing the point at which the protein is equally folded and unfolded, is between 99.8°C and 104.7°C, depending on the solvent. Proline, arginine and tryptophan are known to be involved in protein stabilization. Therefore, we obtained single substitution variants of Ts2631 endolysin by replacing aforementioned residues with alanine. The lytic activity of 31 variants was analyzed against Thermus thermophilus HB8 in turbidity reduction assay. Variants R51A, W53A and R82A revealed reduced activity at 60°C. Five other substitutions R20A, W102A, W109A, P140A, and W145A displayed decreased functionality after heating at 90°C. The thermodynamic stability of all proteins was analyzed using nano differential scanning fluorimetry (nanoDSF). The variants with reduced activity after heat treatment also exhibited significantly lower melting temperatures compared to the wild-type enzyme (ΔTm up to -24°C). Another 24 substitution variants of conserved residues, whose activity was determined in Ts2631 endolysin previous studies, were included in the nanoDSF experiments. The study confirmed that changes of residues involved in direct Zn2+ binding (H30, H131 and C139) have a destabilizing effect on the structure of the Ts2631 endolysin. Substitutions of residues located mainly near the catalytic center of the protein lead to a decrease in its thermostability, which consequently affects the lytic activity of Ts2631. We also found that arginine R20 is involved in peptidoglycan binding. This is the first study of the thermostability mechanism of an endolysin isolated from extremophilic environment.</p
Supplementary materials for the paper "Mechanistic–empirical porosity model for basalt powder-cement pastes under thermal load conditions"
No full textDane badawcze dotyczą wpływu mączki bazaltowej na proces degradacji termicznej zaczynów cementowych. Wpływ mączki bazaltowej sprawdzono poprzez dozowanie w ilości 0-50% względem masy cementu, jako jego zamiennik.Zakres badań obejmował charakterystykę surowców wyjściowych, tj. cementu i mączki bazaltowej. Zbadano skład chemiczny (XRF - fluorescencja rentgenowska), skład fazowy (XRD - dyfrakcja rentgenowska) i uziarnienie (PSD - metoda dyfrakcji laserowej).W celu zbadania degradacji termicznej zaczynów cementowych z mączką bazaltową wykonano badania wytrzymałości na ściskanie (fc), wytrzymałości na rozciągnie (fcf), czasu wiązania (TS), gęstości właściwej (DS), gęstości pozornej (DA), składu chemicznego (XRF), składu fazowego (XRD), struktury porów powietrznych (MIP - porozymetria rtęciowa), skurczu (S), prędkości usuwania wody (E), nasiąkliwości (Wa). Badania wykonywane były w funkcji obciążenia termicznego w zakresie 100-700 oC.Zbiór danych obejmuje swoim zakresem surowe wyniki wszystkich badań zawartych w artykule, opis oznaczeń i receptur, oraz opis metodyki.______________________________________________________________The research data concerns the effect of basalt powder on the thermal degradation process of cement pastes. The effect of basalt powder was tested by dosing it at 0-50% by weight of cement, as a substitute.The scope of the study included characterization of the raw materials, i.e., cement and basalt powder. The chemical composition (XRF - X-ray fluorescence), phase composition (XRD - X-ray diffraction), and particle size distribution (PSD - laser diffraction) were examined.To investigate the thermal degradation of cement pastes containing basalt powder, tests were performed for compressive strength (fc), tensile strength (fcf), setting time (TS), specific density (DS), apparent density (DA), chemical composition (XRF), phase composition (XRD), air void structure (MIP - mercury porosimetry), shrinkage (S), water evaporation rate (E), and water absorption (Wa). The tests were performed as a function of thermal load in the range of 100-700°C.The dataset includes the raw data of all tests included in the paper, a description of the designations and recipes, and a description of the methodology.</p
Data for publication: On the mechanical properties of microfibre-based 3d chitinous scaffolds from selected verongiida sponges
No full textThe dataset includes:SEM images of the cell-free A. aerophoba chitin scaffold’s fibre after decellularisationDigital microscopy images of the A. aerophoba chitin fibre scaffold after decellularisation:Bromotyrosine-containing chitin scaffoldBromotyrosine-free chitin scaffold</p
The personality profile of early generative AI adopters: a Big Five perspective
No full textThe dataset was collected as part of a pilot study investigating the relationship between the Big Five personality traits and user engagement with chatbots during the early stages of AI adoption. The study involved 62 participants, who were divided into two groups and asked to interact with a chatbot to complete predefined tasks. Data collected includes engagement duration, task performance metrics, and participants’ intentions to use AI in the future. Additionally, participants completed a validated Big Five personality assessment to determine individual trait profiles. The dataset served as the basis for analysis exploring how personality traits influence engagement patterns, with the goal of informing more personalized and effective chatbot design.During the experiment participants were asked to solve pre-defined knowledge work related tasks. One group worked with a generative AI chatbot, the other worked alone (column B). The collected data comes from an experimental study. It includes pre-test (columns G-AD), task solutions developed by participants (columns BF-BI), post-test (columns AE-BE), big five results from Happimeter tool (columns BK-BO), and independent judges' scoring of task solution (columns C-F).</p
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