Aperta Turkish Open Archive
Not a member yet
83692 research outputs found
Sort by
Climate Change Corpora
No full text<p>corpora compiled for corpus-assisted discourse analysis of climate crisis in Turkish and English newspaper data covering discursive events across 2021-23.</p>
Synthesis, biological evaluation and theoretical calculation of 2-amino-3-cyano-4-phenylalaninquinolines: anticancer potential and EGFR inhibition
No full text<p>Quinoline derivatives have attracted considerable attention due to their broad spectrum of biological activities, particularly their anticancer potential. In the present study, six novel 4-aminoquinoline derivatives bearing a phenylalanine methyl ester moiety were synthesized and structurally characterized. The cytotoxic activities of the compounds were evaluated against A549 and MCF7 cancer cell lines, as well as the healthy NIH3T3 cell line. Compounds <strong>4d</strong> and <strong>4e </strong>exhibited potent anticancer activity, with low IC₅₀ values, while showing no significant toxicity toward healthy cells. Additionally, these compounds demonstrated moderate inhibitory activity against the EGFR enzyme. Molecular docking studies were performed to reveal the binding modes of compounds <strong>4d </strong>and <strong>4e </strong>at the EGFR active site. To understand better their electronic structures and reactivity profiles, DFT calculations were performed to obtain frontier molecular orbital energies, global reactivity descriptors, dipole moments, and molecular electrostatic potential (MEP) maps. The theoretical data were correlated with the observed biological activities, revealing consistent trends particularly among the active compounds. Furthermore, theoretical NMR chemical shift calculations were also conducted for the synthesized molecules.</p>
Tasavvuf Araştırmaları Lisansüstü Çalışmalar Kılavuzu
No full text<p>Türkiye’de<strong> </strong>tasavvuf alanında lisansüstü eğitim ve öğretime yönelik ilgi her geçen gün artmaktadır. Lisansüstü öğrenciler ve danışmanlarının ilgili bilim alanlarına katkı sağlamak adına sarf ettikleri emeklerden gerekli neticelerin elde edilebilmesi için takip edilmesi gereken genel kabul görmüş araştırma yöntemleri ve akademik yazım teknikleri ve kuralları bulunmaktadır. Savunması yapılacak tezin araştırma yöntemlerine uygun hazırlanması, araştırma etiğine ve yazım kurallarına riayet edilerek kaleme alınması esastır. Editöryal bir çalışmanın semeresi olan bu kitapta tasavvuf alanında yürütülecek lisansüstü çalışmalarda izlenecek araştırma yöntemleri ve yazım tekniklerine dair bazı tavsiyeler başta olmak üzere, son yıllarda dolaşıma sokulan yapay zekâ kullanımı, ilkeler, imkanlar ve riskler, tasavvuf literatürü, bir yazma eser müellifinin tespiti, uygulamalı kitap tanıtımı gibi birbiriyle irtibatlı altı adet bölüm yer almaktadır. Temel İslam Bilimlerinin bir alt disiplini olan Tasavvuf bilim dalı merkezde tutulmak kaydıyla diğer dini disiplinlerde akademik çalışma yapmak isteyen araştırmacılara ve onlara danışmanlık yapan genç akademisyenlere yol gösterilmesi amaçlanmıştır. Bu çalışmalar yapılırken kendileri de halen akademik ve ilmi faaliyetlere öncülük eden hocaların tavsiyeleri ve şahsi tecrübeleri dikkate alınarak böyle bir ürün elde edilmiştir. Yine bu kitapta lisansüstü eğitim ve öğretim kapsamında yürütülecek araştırmalarda, derleme ve değerlendirme gibi konularda ilgili süreçlerde karşılaşılabilecek zorluklar, riskler, engeller vb. konularda rehberlik edilmesinin önemine vurgu yapılmıştır. Keza tasavvuf alanında araştırma yapacak ve yapanların karşılaşacakları muhtemel hatalara dair farkındalık oluşturmak, alanı seçecek, tez yazmaya başlayacak ya da tez yazımında belli bir aşamaya gelen adaylara yardımcı olmak, alandaki tezlerin kalitesini artırmak adına mütevazı bir katkı sunulması hedeflenmiştir. Nitel araştırma hüviyetindeki bu çalışmada uluslararası ölçütlere uygun akademik/bilimsel araştırma yöntemleri ve yönelimlerinin alana uygulanması hususunda bazı tavsiye ve tecrübeler dile getirilmiştir. Çalışmanın detayı bağlamında öncelikle tasavvuf anabilim dalında lisansüstü çalışmalarda karşılaşılan soru ve sorunlar hakkında genel bir çerçeve çizilmiş, akademik/bilimsel araştırma yöntemlerinin alana uygulanması hususunda alanda bilinen akademisyenlerin yazılı çalışmaları dikkate alarak genel bir değerlendirmelerde bulunulmuş, hocaların her biri kendi zaviyelerinden bazı şahsi tekliflere yer vermiş, bunlarla birlikte yeri geldikçe metin içinde adaylara tasavvufun temel konularında bilgilendirme yapılmıştır. Kitabın ağırlıklı bölümünü teşkil eden son kısımda özet kılavuz, alan okumalarını ihtiva eden kitaplar listesi, anlatım bozukluklarına dair bilgiler ile noktalama işaretlerinin doğru kullanımı konusunda bazı ekler konulmuştur.</p>
Mechanisms of hardness enhancement in CrB2 thin films with varying VB2 concentrations
No full text<p>Transition metal borides are well-known for their high hardness, excellent wear resistance, chemical inertness, and electrical conductivity, making them promising for a wide range of applications. Understanding the interconnections between material structure, composition, and mechanical properties is essential for designing and synthesizing effective coatings. This study systematically investigates the structural and mechanical properties of CrB2 thin films with varying concentrations of VB2 (0-10 wt%), focusing on structure, hardness, elastic behavior and deformation characteristics mechanisms through atomic force microscopy and nanoindentation measurements. The results show that increasing VB2 content leads to the formation of island cluster structures, which significantly strengthens atomic bonds and, in turn, enhances the hardness of the thin films. As particle size decreases, the higher proportion of surface atoms and increased surface energy have a more pronounced effect on the mechanical properties. In particular, the addition of VB2 up to 10 wt% in CrB2 thin films results in a marked improvement in superhard properties. 26 % increase in hardness value is also influenced directly by the changes in Young's modulus and Poisson's ratio that depend on the VB2 concentration.</p>
Proteolysis-resistant extracellular uricase from the sponge-derived <i>Streptomyces rochei</i>
No full text<p>This study aimed to identify proteolysis-resistant extracellular uricase by screening three hundred marine microorganisms, including bacteria, actinobacteria and filamentous fungi. The isolate, demonstrating resistance to proteolysis and producing extracellular uricase with relatively high activity was identified as Streptomyces rochei 6SM85. The enzyme was purified approximately 3.6 fold, yielding 1.23%, using ion exchange chromatography. The molecular weight of the purified uricase was estimated to be approximately 14 kDa by SDS-PAGE. The optimum temperature and pH for uricase were determined to be 35 degrees C and 8-9, respectively. It was demonstrated that uricase retained up to 46% of its activity after half an hour at 40 degrees C and exhibited higher activity at neutral and basic pH compared to acidic pH. Its activity increased in the presence of 1 mM Mg2+, Na+, and EDTA, while it decreased by 86% in the presence of Cu2+. This study represents the first report on the production and characterization of extracellular proteolysis-resistant uricase from marine-derived Streptomyces.</p>
A low-cost instrumentation for monitoring of the environmental radioactivity
No full text<p>In this work, a low-cost radiation monitoring instrumentation for measuring the environmental gamma radioactivity together with some atmospheric parameters was designed and produced. The device has been built with market available components. The detector section of the device uses a Si-PIN photo-diode as an active element. A tiny current produced from the energy deposition of gamma rays in silicon is amplified in two stages, firstly with a charge sensitive amplifier (CSA) and secondly with a shaping amplifier (SA). The amplified signal is further processed to be converted into digital pulses for counting. The monitor station is designed to be operated remotely in self-sufficient mode, equipped with LoRA module running at 500 MHz to transfer the data remotely to abase station. The base station also includes a LoRA module to receive the data and stores it in an SD card while an OLED display visualizes the recent measurement. Multiple monitor stations can be used to control the radioactivity level in afield simultaneously. This field could be used inside or outside of an interested facility. The noise limit of the detector developed was determined to be as low as 20 key photon energy. The low-energy detection limit was conservatively set to 40 key which was still below the 64 key of the naturally occurring 234 Th. Counting the events for hourly, daily or weekly provide statistically significant data depending on the activity of the interested region. All gamma energies above 40 key from the decays of naturally occurring radioisotopes can be practically observed with this device. The anomalies can be detected using various mathematical algorithms that can be embedded into the microprocessor and the results can be shared with the public.</p>
Impact of pulsed electric fields technology on surface disinfection and quality properties of pistachios
No full text<p>Pistachios are contaminated with pathogenic and spoilage microorganism from harvesting to packaging resulting in quality degradation and safety issues. Disinfection of the pistachio by heat application provides reduction on microbial load, but it also causes undesirable changes in quality properties. Thus, processing of Antep pistachios by pulsed electric fields (PEF) with inactivation of microbial flora, and determination of changes on quality and sensory properties were studied. Application of 71.23 J/kg energy and 28.8 kV/cm electric field strength by continuous PEF system resulted in 4.73, 5.21, 5.56, and 4.87 log cfu/g reductions on Salmonella spp., total mesophilic aerobic bacteria, total mold and yeast, and total coliform bacteria, respectively. Although peroxide value, total fat content, total antioxidant capacity, total phenolic substance content, and total chlorophyl content were increased by applied energy (p <= 0.05), no significant difference was observed on color, total acidity, and sensory properties (p > 0.05). Concentration of fatty acids were changed by the applied treatments. Development of nonthermal treatments to process nuts with surface disinfetion and preservation of quality and sensory properties can ensure product safety and prevent product loss. PEF treatment providing inactivation of pathogenic and endogenous microbiota with preservation of quality properties brings an alternative to nut industry.</p>
Self-cleaning superhydrophobic polyester resin production for gel coat applications
No full text<p>This research aimed to develop a superhydrophobic unsaturated polyester resin for gel coat applications, hypothesizing that modifying the primary component, polyester resin, to be superhydrophobic would impart the same property to the gel coat. To achieve this, coating solutions were prepared using two different strategies. The first approach involved complementing resin modification with a condensation reaction. The second strategy involved modifying the polyester resin through simultaneous radicalization and condensation polymerization. The superhydrophobic, self-cleaning gel coat applications were applied using a spray coating technique. Subsequently, wettability tests, including contact angle measurements and self-cleaning performance assessments, as well as surface morphology analyses using SEM, AFM, and XPS, were conducted. Additionally, structural characterizations of the composite material were performed using FTIR, XRD, and TGA. The water contact angle of the unmodified polyester resin, initially 84 degrees, increased to 173 degrees, demonstrating the successful production of superhydrophobic polyester resin. It is believed that the produced gel coat will not only result in significant labor savings due to its self-cleaning properties and corrosion protection but will also reduce the use of environmentally harmful cleaning agents.</p>
A retrospective descriptive study of male perpetrators of intimate partner violence referred by judicial authorities: an example from Turkey
No full text<p>PurposeOur study examines the socio-demographic, forensic psychiatric, and childhood trauma exposure (CTE) data of Turkish intimate partner violence (IPV) perpetrators and draws comparisons with the violence data.MethodsData of male perpetrators referred to the domestic violence outpatient clinic by judicial authorities between November 2019 and June 2022 were retrospectively examined, with a focus on CTE data.ResultsThe mean age of the male perpetrators examined in the study was 37.1 years. Among the overall sample, 16.2% (n = 17) had experienced violence at school in childhood, and 22.9% (n = 24) had experienced CTE. Regarding the frequency of domestic violence in their households, of the perpetrators admitted to the clinic for IPV, 40% (n = 42) reported rarely, 43.8% (n = 46) sometimes, and 16.2% (n = 17) often engaged in violent acts. There is a significant relationship between the frequency of IPV and the level of CTE (chi 2: 13.052, SD: 2, p = 0.001, Cramer's V: 0.353). Similarly, individuals who witnessed domestic violence during childhood were found to commit partner violence more frequently (chi 2: 8.157, SD: 2, p = 0.017, Cramer's V: 0.279).ConclusionsIn this study, we found a strong relationship between CTE and IPV. To the best of our knowledge, our study is only example that investigates the relationship between CTE and IPV in a Turkish sample.</p>
Population genetic structure of the bottlenose dolphin in the Turkish waters based on mtDNA sequences with implications for the Black Sea subspecies <i>Tursiops truncatus ponticus</i>
No full text<p>The bottlenose dolphin is a widely distributed species found in temperate waters, including the Mediterranean and Black Seas. The Black Sea population is recognized as a distinct subspecies, Tursiops truncatus ponticus, due to genetic and morphological differences. This study analyzed mitochondrial DNA (mtDNA) sequences of 73 bottlenose dolphin samples collected between 1999 and 2016 along the Turkish Black Sea coast, Turkish Straits System (TSS), Aegean, and Mediterranean Seas revealing 14 haplotypes, eight of which are reported here for the first time.The haplotype network shows two main nodes with star-like sub-networks, but no apparent geographic pattern. The lack of geographical groupings of haplotypes indicates the high mobility of the species within the sampled area. The northern Black Sea bottlenose dolphins (NBS) appear to be genetically differentiated from those in the southwestern Black Sea (SBS), Mediterranean, and Atlantic Ocean, but not from the TSS and Aegean Sea populations. Besides, SBS bottlenose dolphins were differentiated only from those in the western Mediterranean (WM) and the Atlantic. Therefore, NBS and SBS bottlenose dolphins should at least be categorized as different populations. However, contrary to some previous studies there was no evidence supporting the classification of Black Sea bottlenose dolphins as a separate subspecies.The TSS differs only from the Atlantic and the Aegean, and functions like a migratory 'melting pot' for surrounding populations. Despite the largest sample size, NBS bottlenose dolphins exhibited the lowest haplotype and nucleotide diversity. This low genetic diversity and potential isolation from adjacent populations highlight the need for prioritizing the conservation of NBS bottlenose dolphins.</p>