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Tane Heterojenitesi ve Farklı Anaçların Papazkarası Üzüm Çeşidi Tane Özelliklerine Etkisi
No full text<p>Deneme Kırklareli ili Pınarhisar ilçesinde İrem Çamlıca Bağcılık ve Şarapçılık Ltd. Şti. bağında yürütülmüştür. Bitkisel materyal olarak on yaşında olan; Papazkarası/1103P, Papazkarası/110R ve Papazkarası/420A aşı kombinasyonu omcaları seçilmiştir. Çalışmada farklı anaçlara aşılı Papazkarası üzüm çeşidi salkımlarından alınan tanelerin özellikleri belirlenmiş ve tane heterojenitesinin tane özelliklerini nasıl etkilediğinin ortaya konmuştur. Bu amaçla, hasat edilen salkımlardan alınan taneler boyutlarına göre sınıflanmıştır; ≤12 mm (B2); 12,01-14,00 mm (B3); 14,01-16,00 mm (B4); 16,01-18,00 mm (B5) ve ≥18 mm (B6). Ayrıca kontrol (B1) boyut grubu toplam tane sayısının tane boyutlarına dağıtılmasıyla oluşturulmuştur. Tane özelliklerini ortaya koymak için; tane eni-boyu, tane yaş ve kuru ağırlığı, 100 tane ağırlığı, tane hacmi ve 100 tane hacmi kriterleri incelenmiştir. Ayrıca; tane özkütlesi, % kuru ağırlık, TKA/TH, şeker konsantrasyonu, tanede şeker miktarı, 1g tanede şeker miktarı ile verim belirlenmiştir. Sonuç olarak, düşük vigora sahip 420A anacının tane özellikleri açısından şaraplık çeşitlerde istenilen en düşük değerlere sahip olduğu; öte yandan tane özkütlesi, % kuru ağırlık ve TKA/TH değerlerinin de yüksek olması sebebiyle öne çıktığı belirlenmiştir. Tane boyutları açısından da en yüksek tane sayısının 12,01 mm ile 18,00 mm arasında yer alan boyut gruplarında olduğu saptanmıştır. Üzüm kalitesi açısından bu boyutlar arasındaki taneler, yüksek kaliteli olmamakla birlikte şarap üretimi için idealdir. Öte yandan B2 (≤12,00 mm) ve B6 (≥18,00 mm) boyut gruplarında istenilen tane sayısına erişilememiştir.</p>
A new approach to the directional derivative of fractional order
No full text<p>The fractional derivative approximations offer many approaches to understanding real-world problems. The conformable fractional derivative operator that is one of the fractional derivative operators has recently attracted a lot of interesting. In this paper, a new approach to the directional derivative obtained with the help of the conformal fractional derivative is presented. Considering this approach, the definition of the fractional partial derivative is reformulated. In addition, a new definition of fractional gradient, fractional curl, and fractional divergence is given, and the properties of these new concepts are examined.</p>
Decoding the DNA of Anatolian Water Buffalo by Genome-Wide Discoveries for Body Size and Ultrasound Carcass Traits
No full text<p><strong>Background</strong></p>
<p>Body size and carcass traits are economically significant in livestock, contributing to productivity and meat quality improvement in breeding programs. Understanding the genetic basis of these traits can enhance selection strategies for livestock improvement. This research was carried out to identify genomic regions associated with body size and ultrasound carcass traits using the single-step genome-wide association study (ssGWAS) in Anatolian water buffaloes. Data consisted of wither height (WH), hip height (HH), body length (BL), chest width (CW), hip width (HW), chest circumference (CC), cannon-bone circumference (CBC), Musculus longissimus dorsi depth (MLDD), and subcutaneous fat thickness (SFT) records of 313 yearling buffaloes were used in the analysis. Genotyping was carried out by using the 90K Axiom Buffalo Genotyping array. Association analyses using genomic relationship matrix (GRM) were performed by WOMBAT software. </p>
<p><strong>Results</strong></p>
<p>Twenty SNPs were found to be genome-wide significant according to the FDR thresholds controlled at p < 0.01. Genes previously associated with body size and fat-related traits, including <em>TRPC7</em>, <em>CEP290</em>, <em>KITLG</em>, <em>TMTC3</em>, <em>NELL2</em>, <em>DBX2</em>, <em>GLI2</em>, <em>BRINP1</em>, <em>TLR4</em>, <em>NYAP2</em>, <em>SORCS3</em>, <em>PIK3C3</em>, <em>LEP</em>, <em>RSPO2</em>, and <em>GTPBP4</em>, were notably identified in this study.</p>
<p><strong>Conclusion</strong></p>
<p>The identification of novel and previously associated genes could enhance genetic improvement, contributing to the understanding of the genetic basis of body morphology in buffaloes.</p>
Visual Attention in Joint Attention Bids: A Comparison Between Toddlers with Autism Spectrum Disorder and Typically Developing Toddlers
No full text<p>Impairments in joint attention are considered core symptoms of autism spectrum disorder (ASD) and are crucial for early assessment and intervention. However, existing information about visual attention during joint attention and its relation to developmental functioning is limited. The current study investigated the visual attention differences between toddlers with ASD and typically developing (TD) toddlers during single and multiple joint attention cue conditions. This study further examined whether visual attention in joint attention Area of Interests (AOIs) is related to cognitive, language, and motor development in participants. Participants included 56 toddlers with ASD and 56 TD toddlers, aged 18-36 months. A passive viewing paradigm was used to assess participants' visual attention across four different joint attention conditions. Study results showed that toddlers with ASD displayed limited visual attention towards joint attention AOIs, Target, Face, and Target and Face AOIs, in all conditions. As the joint attention cues increased from Condition 1 to Condition 4, toddlers with ASD showed increased visual attention directed towards the Target AOI over the Face AOI. Moreover, increased visual attention on the joint attention AOIs was associated with improved cognitive and language development in toddlers with ASD. This research broadens our understanding of the positive relationships between visual attention to joint attention AOIs and cognitive as well as language development in toddlers with ASD, suggesting that early interventions targeting joint attention may offer promising pathways for treatment.</p>
Photoelectrochemical Investigation of Hole Scavengers for Photocatalytic Hydrogen Evolution Reaction on Perovskite-Type Niobate Nanosheets
No full text<p>Hole-scavengers are a crucial part of particulate photocatalytic systems. The use of hole-scavengers increases the photocatalytic activity by preventing electron-hole recombination. The holes are used in photo-oxidation of the hole-scavenger molecules increasing the probability of electrons involved in photoreduction of water. In this study, different hole-scavengers utilized in photocatalytic water splitting reaction were tested. The impact of different hole scavengers on photocatalytic reactions were investigated on [Ca2Nb3O10]- 2D nanosheets mechanistically. Cyclic voltammetry and chronoamperometry tests were employed to assess the impact of hole scavengers on photocatalytic efficiency. The photoelectrochemical tests agree with the results of the photocatalytic reactions. Methanol and EDTA give the largest oxidation photocurrent and the best photocatalytic activity.</p>
Kuşaklar Arasında Annelik: Siirt Örneğinde Değişen Roller ve Algılar
No full text<p>Annelik olgusu, sosyal, kültürel, biyolojik alanları içermesinden dolayı farklı boyutlarla ele<br>
alınmayı gerektiren bir alandır. Kadının annelik kimliğinin oluşması, biyolojik yapısının<br>
yanı sıra toplumsallaşma süreçlerinden de etkilendiği bir durumdur. Başka bir ifade ile kadınlardan beklenen çalışma hayatı ve ailevi sorumluluklar, kadınlar üzerinde baskı yaratmakta ve bu süreçteki mücadele yetisi kadının kimliğini belirlemektedir. Annelik olgusuna<br>
tarihin farklı dönemlerinde çeşitli anlamlar yüklenmiş, küreselleşme olgusuyla önemli dönüşüm gözlenmiştir. Bu gelişim ve dönüşümler birçok şeyi etkilediği gibi kadınların annelik<br>
rollerini de etkilemiştir. Yaşanan bu değişimlere binaen bugünkü toplumumuzda anneliğin<br>
dönüşümünü sosyolojik perspektiften değerlendirmek, annelik rollerinin anlaşılması adına<br>
önemli bir durumdur. Bu bağlamda araştırmanın amacı eril cinsiyet üzerinde kadına dayatılmış cinsiyet rolü olan anneliğe yüklenilen anlamı sosyolojik açıdan görünür kılmaktır.<br>
Çalışma; anneliğin çeşitli söylemlerin odağında yeniden üretilen konumuna ilişkin bir tartışma yürütmeyi amaçlamaktadır. Çalışma dâhilinde annelik olgusunun farklı kuşaklar arasında ne anlam ifade ettiği üzerine yoğunlaşılmaktadır. Çalışma kapsamında görüşülen 15<br>
Siirtli kadının üçte biri 65 yaş ve üzeri, üçte biri 35-64 yaş aralığında, üçte biri 35 yaşından<br>
küçük kadınlardan oluşmaktadır. Görüşmelerde katılımcıların hepsi anneliği yücelten söylemler ile anneliği tanımlayarak anneliğin ön koşullarından birinin fedakârlık olduğu, anneliğin kutsal olduğu konusunda hemfikirdirler. Fakat fedakârlığın şekli yaşlı kuşak ile orta<br>
ve genç kuşak arasında farklılaşmaktadır.</p>
High efficiency green and red emitting CdSeTe quantum dots: Synthesis and PLQY improvement for optical applications
No full text<p>Obtaining stable QDs with different emission colors and high PLQY values for optoelectronic applications is important. There are currently applied treatment methods to increase the PLQY value and stabilization of QDs. On the other hand, variations in the surface-to-volume ratio associated with changes in QD size indicate that the treatment methods applied must be optimized according to the specific size of the QDs. This study focuses on the optimization of the synthesis and treatment processes of green and red emission CdSeTe QDs with high PLQY for use in optoelectronic devices. Initially, the synthesis processes for green and red emission QDs were optimized according to precursor molar amounts, synthesis time and synthesis temperature. Then, chloride treatment, CdS and ZnS shell coating methods were optimized and applied separately to increase the PLQY values of these QDs. The results showed that the PLQY value increased up to 95.23 % with 30 % CdCl2 treatment by mass for green emitting CdSeTe QDs and up to 96.31 % with 40 % CdCl2 chloride treatment by mass for red emitting QDs. The study includes a comprehensive comparison of emission, absorption, XRD, elemental analysis, CV, PL lifetime, HR-TEM analysis and stabilization analysis for the synthesized CdSeTe QD types.</p>
Overcoming Acquired 5-FU Resistance in Gastric Cancer: Oleuropein Targets Proliferation, Migration and Survival Pathways
No full text<p>5-Fluorouracil (5-FU) remains a cornerstone in gastric cancer (GC) treatment; however, chemoresistance limits its efficacy. Oleuropein (OL), a phenolic compound in olive leaf extract, has emerged as a low-toxicity candidate with antitumor-potential. A 5-FU-resistant AGS subline (AGS-FUR) was established via stepwise drug exposure. The effects of OL-only or in combination with 5-FU, on proliferation (xCELLigence), apoptosis (Annexin V/PI), ROS, colony formation, migration, and EMT/CSC gene expression and proteomic analyses were assessed in AGS and AGS-FUR cells. OL exhibited dose- and time-dependent anti-proliferative effects, with IC50 values of 73.86µM in AGS cells and 94.58µM in AGS-FUR cells (p<0.0001). Combination therapy showed additive efficacy, significantly increasing apoptosis (p<0.0001) and partially reversing resistance-associated survival. Notably, OL reduced ROS even in AGS-FUR cells but retained proapoptotic effects, suggesting a redox-independent mechanism. In resistant cells unresponsive to 5-FU, combined treatment suppressed colony formation 22.2-fold (p<0.0001). OL also downregulated the CSC markers <em>CD133</em> and <em>NANOG </em>(p<0.05) and inhibited migration/EMT by reducing wound closure and repressing the effects of 5-FU alone on the expression of <em>CDH2</em> (22.2-fold; p<0.0001) and <em>ZEB1</em> (3.83-fold; p<0.05). Proteomic profiling identified 3.392 proteins, of which 232 were highly confidently differentially expressed. Resistance is associated with alterations in chromosome organization, mitochondrial function, and RNA processing. Strikingly, OL suppressed protein levels in AGS cells but upregulated them in AGS-FUR cells, indicating opposing cell line-specific regulation. Overall, OL enhances 5-FU efficacy by impairing proliferation, stemness, and invasion while modulating EMT and apoptosis, underscoring its potential as an adjuvant for overcoming GC chemoresistance.</p>
Forensic identification using airDNA: A preliminary study on the collection, isolation, amplification and sequencing of human DNA from air samples
No full text<p><strong>Background/aim:</strong> Humans continually release skin cells and DNA fragments into the air. This DNA can either remain airborne or settle onto surfaces as indoor dust. This study investigates the collection, isolation, amplification, and sequencing of human DNA from air samples, focusing on both nuclear and mitochondrial DNAs.</p>
<p><strong>Materials and methods:</strong> This study was conducted in a 15 m<sup>3</sup> room and a meeting room where air samples were systematically collected and filtered using a vacuum device equipped with various sterile filters. The rigorous protocols were implemented to prevent contamination throughout the process. Thirteen air samples were processed in this research, involving the participation of two females and two males.</p>
<p><strong>Results:</strong> The study demonstrated the feasibility of extracting and sequencing human mtDNA from air samples, while nuclear DNA quantification remained challenging. Notably, cotton filters yielded better mtDNA sequencing results compared to glass fiber filters. Despite limited nuclear DNA recovery, mtDNA sequencing was successful in several samples, providing interpretable DNA profiles.</p>
<p><strong>Conclusion:</strong> This preliminary study highlights the potential use of airDNA in forensic investigations, emphasizing mtDNA sequencing as a viable approach when nuclear DNA is scarce. Future studies should prioritize mtDNA sequencing and consider using glass fiber or cotton filters for optimal airDNA collection.</p>This work was supported by the Rapid Support Fund of Yeditepe University (Project Number: HD-23027). The funding source was not involved in study design in the collection, analysis, and interpretation of data in the writing of the report, and in the decision to submit the article for publication.
We extend our gratitude to Biologists Ayşe BIÇAK ÇERKEZİ and Oktay ATEŞ from the Department of Biology at the Presidency of the Council of Forensic Medicine for their invaluable contributions to the laboratory processes
Deenz Avoidant Personality Scale Dataset
No full text<p>Deenz Avoidant Personality Scale (DAPS-24) dataset comprises responses from 43 participants who completed the scale as part of a study on avoidant personality traits. The DAPS-24 is a psychometrically validated instrument designed to assess six key dimensions of avoidant personality: social inhibition, feelings of inadequacy, hypersensitivity to criticism, preoccupation with criticism, limited social circle, and longing for social connection. The scale captures varying levels of avoidant tendencies in both clinical and non-clinical populations, allowing for a nuanced understanding of how these traits manifest and impact interpersonal relationships and psychological well-being.</p>
<p><strong>Dataset Details</strong></p>
<p>The dataset includes self-reported responses collected through a 24-item Likert scale, where participants rated statements from 1 (Strongly Disagree) to 5 (Strongly Agree). The dataset consists of 43 unique participants aged between 19 and 48, representing a diverse range of individuals with varying degrees of avoidant personality traits. Each participant's responses are recorded across six core dimensions, with corresponding scores that reflect their level of social withdrawal, sensitivity to negative evaluation, and interpersonal difficulties.</p>
<p>In addition to responses on the avoidant personality dimensions, the dataset includes demographic variables such as age and gender, allowing researchers to explore potential correlations between demographic factors and avoidant personality traits. The dataset is available in CSV format, structured to facilitate statistical analysis and validation of the scale’s psychometric properties. Given the scale's multidimensional nature, the dataset can be used to analyze individual differences in avoidant tendencies, identify patterns of social withdrawal, and examine how different facets of avoidance interact with one another.</p>
<p><strong>Usage and Purpose</strong></p>
<p>This dataset serves as a valuable resource for researchers, clinicians, and mental health professionals studying avoidant personality traits and their broader implications. It provides a foundation for exploratory analysis, validation studies, and further refinement of the DAPS-24 as a diagnostic and assessment tool. By analyzing this dataset, researchers can gain deeper insights into the underlying structure of avoidant personality traits, assess the scale's reliability and validity across different populations, and explore potential interventions for individuals exhibiting high levels of avoidance. The dataset may also be used in clinical settings to refine treatment approaches, particularly in cognitive-behavioral therapy (CBT) and other interventions aimed at improving social functioning and reducing avoidance-related distress.</p>
<p> Additionally, the DAPS-24 is available in a computerized format with automatic scoring and visual feedback for enhanced assessment: <strong><a href="https://drdeenz.com/avoidant-personality-disorder-test/">https://drdeenz.com/avoidant-personality-disorder-test/</a></strong>.</p>