Ho Chi Minh City Open University Journal of Science
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School Administrator’s Perceptions of Digital Well-Being: Constant Connectivity, Burnout, and the Pursuit of Digital Balance
No full textTHE EFFECTS OF FEBRUARY 2023 EARTHQUAKES CENTERED IN KAHRAMANMARAŞ AND HATAY, TURKIYE ON THE REGION'S AGRICULTURAL SECTOR
No full textN95 mask usage in children with type 1 diabetes mellitus: Does it affect clinical outcomes?
No full textSHORT TERM EFFECTIVENESS OF LOCAL AUTOLOGICAL PLATELET-RICH PLASMA (PRP) INJECTION IN THE TREATMENT OF WOMEN WITH STRESS URINARY INCONTINENCE
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Ameliorative Effects of Nettle (Urtica dioica) Seed Extract on Methotrexate-Induced Hepatorenal Damage in Rats
No full textIn this study, it was aimed to examine the potential therapeutic effects of Urtica dioica seed (UDS) oil on hepatorenal damage induced by methotrexate in rats. Thirty-two Wistar albino rats were divided into four groups: Control, Methotrexate (MTX, 20 mg/kg i.p.), UDS (30 ml/kg feed containing UDS), and MTX+UDS (20 mg/kg i.p. + 30 ml/kg feed containing UDS oil, respectively). At the end of the six-week study, the MTX-treated group demonstrated elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in serum and increased levels of malondialdehyde (MDA), an indicator of lipid peroxidation in liver, kidney, and blood tissues. However, reduced glutathione (GSH) levels (apart from erythrocytes) showed a significant decrease (p<0.005). The MTX group's liver and erythrocyte tissues showed a significant decrease in glutathione reductase (GR) activity compared to the control. Additionally, there was a significant decrease in the activities of glutathione peroxidase (GPx) and catalase (CAT) in the MTX group as compared to the control. The co-administration of MTX+UDS decreased liver MDA concentration and the levels of the enzymes AST, ALT, and LDH compared to the MTX group. On the other hand, there was an increase in kidney glutathione S-transferase (GST) activity and GSH levels. Histopathological investigation revealed that pellets containing UDS oil significantly reduced the degenerative and necrotic changes that MTX had generated in the liver and kidney, including parenchymal and hydropic degeneration and inflammatory cell infiltration. Immunohistochemical staining showed that caspase 3, a marker of apoptosis, decreased significantly with the administration of UDS oil. In conclusion, MTX-induced hepatorenal damage was either prevented or greatly decreased by UDS oil
FABP4 as a therapeutic host target controlling SARS-CoV-2 infection
No full textHost metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections, though the underlying mechanisms remain unknown. Our study highlights fatty acid-binding protein 4 (FABP4), a key regulator of metabolic dysfunction and inflammation, as a modulator of SARS-CoV-2 pathogenesis, correlating strongly with disease severity in COVID-19 patients. We demonstrate that loss of FABP4 function, by genetic or pharmacological means, reduces SARS-CoV-2 replication and disrupts the formation of viral replication organelles in adipocytes and airway epithelial cells. Importantly, FABP4 inhibitor treatment of infected hamsters diminished lung viral titers, alleviated lung damage and reduced collagen deposition. These findings highlight the therapeutic potential of targeting host metabolism in limiting coronavirus replication and mitigating the pathogenesis of infection
Evaluation of Nurse-Patient Language Barrier Issues: A Qualitative Study on the Views of Psychiatric Clinic Nurses
No full textRationale: Effective communication, which is critical for quality care and therapeutic relationships in psychiatric nursing, becomes difficult when hindered by language barriers. This makes it challenging for nurses to fulfil their caregiving roles, establish trust with patients, and support the treatment process. Therefore, it is essential to evaluate nurses' experiences with language barriers when providing care to their patients. Aim: This study aims to identify the language barriers experienced by nurses working in an acute psychiatric clinic who are unable to communicate in the same language as their patients, and to determine possible strategies to overcome these challenges. Method: The study was designed as a qualitative case study. The participants were eight nurses working in a state hospital's acute psychiatric clinic in Türkiye. The data was collected with a semi-structured interview guide. Then it was transcribed and coded through content analysis. Findings: Three main themes emerged: (1) professional implications of communication in psychiatric care, (2) challenges related to language barriers, and (3) proposed solutions. Conclusion: The findings suggest that integrating psychiatric nurses' insights on language barriers is crucial for delivering high-quality healthcare in psychiatric care. It has been determined that language differences between patients and nurses affect the quality of care and pose a threat to establishing and maintaining a therapeutic relationship based on trust between nurses and patients. These problems disrupt the psychiatric treatment and care process. Psychiatric nurses have proposed individual and institutional solutions to these problems, as well as practical solutions aimed at establishing trust
Dose- and Duration-Dependent Effects of Propylene Glycol on Lipid Metabolism-Related mRNAs, Proteins, and Fatty Acids in the Adipose Tissue of Fattening Akkaraman Lambs
No full textPropylene glycol (PG) is incorporated into ruminant diets to boost glucogenic energy availability, yet its precise effects on adipose tissue development remain incompletely defined. The study was designed as a 3 × 3 factorial experiment with two independent variables: dose of PG and duration of fattening. Three groups were formed, including a dose group of PG 1.5 mL/kg live weight (PG1.5), a dose group of PG 3 mL/kg live weight (PG3), and a group without PG (PG0). Gluteal adipose tissues were collected from animals slaughtered on days 60, 90, and 120. mRNA, protein, and fatty acid profiles were analyzed. Protein–protein interaction and gene set enrichment analysis were also performed. On day 60, FABP4 was approximately 3-fold higher at both mRNA and protein levels in PG3 compared to PG0, nearly 2-fold higher at the protein level in PG1.5, and SREBP-1c protein levels were reduced in PG1.5 compared to PG0. On day 120, FABP4, PPARγ, C/EBPα exhibited an increasing trend at both mRNA and protein levels in PG groups, whereas SREBP-1c was decreased in PG3. Fatty acid profiling revealed C16:0, C18:0, and C18:1 comprised over 70% of total lipids. PG supplementation shifted the profile toward unsaturated species, reducing saturated fatty acid proportions and enhancing nutritional indices, particularly in PG1.5. Findings at the bioinformatics levels demonstrate PG exerts clear dose- and time-dependent modulation of adipogenic transcription factors, fatty acid composition, and molecular interaction networks in lamb adipose tissue. Early PG3 feeding elevates FABP4 and suppresses SREBP-1c, whereas prolonged supplementation enhances PPARγ and C/EBPα and drives a favorable shift in lipid profiles. Network and pathway analyses reveal coordinated regulation via NR1H3/RXR and PPAR axes, suggesting PG not only optimizes energy partitioning but also supports cellular homeostasis. These results could contribute to the development of potential strategies aimed at supporting adipose tissue quality and metabolic health in sheep