Ho Chi Minh City Open University Journal of Science
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    Pharmacokinetics of tolfenamic acid in ducks (<i>Anas platyrhynchos domestica</i>) after different administration routes

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    1. The objective of this research was to compare the pharmacokinetics and bioavailability of tolfenamic acid, analgesic, antipyretic and anti-inflammatory compound, after administration through different routes to Pekin ducks. The investigation was carried out over four time periods using a randomised cross-pharmacokinetic design.2. Tolfenamic acid was administered to ducks intravenously, intramuscularly, subcutaneously and orally at a dose of 2 mg/kg. Tolfenamic acid analysis was performed using HPLC-UV and pharmacokinetic data were conducted by non-compartmental analysis.3. The total clearance, volume of distribution at steady state and terminal elimination half-life after intravenous administration were 0.14 l/h/kg, 0.29 l/kg and 1.80 h, respectively. The peak plasma concentration and bioavailability for intramuscular, subcutaneous and oral administration were 4.59, 3.55 and 2.23 mu g/ml and 93.62, 74.30 and 43.43%, respectively.4. Tolfenamic acid was absorbed rapidly, eliminated quickly and exhibited a small distribution volume in Pekin ducks. Pharmacokinetic parameters, including maximum concentration, area under the plasma concentration - time curve and bioavailability, were found to be different in ducks from other bird species

    Person-centered perioperative nursing levels of surgical nurses and factors affecting them

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    Background/Aim: There is evidence that effective perioperative care provided by nurses shortens the length of hospital stay, particularly in surgical units. However, studies on the level of perioperative nursing by nurses are limited. This study aimed to analyze the level of person-centered nursing by nurses working in surgical units and the factors affecting them.Methods: This cross-sectional descriptive study was conducted between July and August 2023 through face-to-face interviews with 150 nurses working in surgical units of two government hospitals in Adana and Nevşehir provinces who agreed to participate. Data were collected using the "Nurse Introductory Information Form" and the "Person-Centered Perioperative Nursing Scale (PCPON)".Results: It was found that 52% of the nurses were aware of person-centered care, and 71.3% did not believe that the same care should be applied to each patient. The mean score of the PCPON for nurses working in surgical units was 77.233 (14.62). There was a statistically significant difference between the PCPON scores of nurses working in intensive care units, those who chose the nursing profession willingly, those who willingly worked in surgical units, and those with knowledge of person-centered nursing (P&lt;0.05).Conclusion: This study revealed that nurses working in surgical units demonstrated a high level of person-centered perioperative nursing performance. Factors such as willingly choosing the nursing profession, willingly working in surgical units, and educational status were found to influence perioperative nursing.</jats:p

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    Ho Chi Minh City Open University Journal of Science
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