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Reciprocal Eelgrass Seed Restoration Monitoring Data Across NC and VA Sites
No full textThis dataset includes field monitoring data from a reciprocal seed restoration experiment conducted at multiple Zostera marina transplant sites in North Carolina and Virginia during the 2024 growing season. The data include information on source and transplant sites, seagrass cover, shoot density, shoot height, and reproductive effort across quadrats established in each restoration plot. The purpose of this dataset is to evaluate performance differences among eelgrass seed sources under varying environmental conditions and site locations
Supplemental Files for: Aerosolized Vitamin D Attenuates Ozone-Induced Inflammation and Transcriptional Responses Through Membrane Antioxidant Effects in Human Bronchial Epithelial Cells
No full textOzone exposure can lead to increased risk of infection, exacerbation or pathogenesis of lung disease, and a number of systemic health effects. As worldwide ambient ozone levels continue to cause adverse health effects, there is a need for prophylactic interventions to mitigate the harmful health effects of ozone. Vitamin D has well-established anti-inflammatory properties and circulating levels have been inversely associated with numerous lung pathologies including ozone-induced airway inflammatory responses and decrements in lung function. Interestingly, studies on oral supplementation to treat lung disease have produced mixed results, potentially due to unfavorable pharmacokinetics in the pulmonary endothelium leading to failure of circulating vitamin D to reach the airways. Here, we tested a novel intervention using vitamin D aerosols to attenuate ozone-induced pathological responses in primary human bronchial epithelial cells. We exposed cells at an air-liquid-interface to ozone following vitamin D pre-treatment and found that both basolateral and apical aerosol pretreatment with vitamin D reduced the ozone-induced secretion of the pro-inflammatory cytokine, IL-8. Similarly, ozone-induced upregulation of inflammation- and oxidative stress-related genes such as IL-8, FFAR2, COX-2, and NFKB2 were downregulated with both basolateral and apical aerosol vitamin D treatment and gene set enrichment analysis (GSEA) revealed that vitamin D treatment reversed ozone-induced increases in inflammation, oxidative stress, and immune dysfunction pathways. In addition, vitamin D pre-treatment attenuated lipid peroxidation, glutathione oxidation, and formation of ozone-derived oxysterols, indicating that vitamin D may act as a membrane antioxidant. These results provide support for the use of vitamin D as a protectant against inhaled oxidants and support the need for further investigation into inhaled vitamin D as a novel route of delivery for treating lung pathologies
Data Management and Sharing Plan for: Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesis
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Development and Application of Reactions to Enable Molecular Rigidification
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Collaborative Research: Efficient Individualized Treatment Selection for Personalized Medicine
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Improving the equity, actionability, and effectiveness of electronic patient-reported outcomes for clinical cancer care
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Investigating UBE3A as a driver gene in Duplication 15q syndrome
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Scoping Review Protocol - Pharmacy-based Methadone Dispensing
No full textThis is a scoping review protocol for a paper on the barriers and facilitators to pharmacy-based methadone dispensing
Data Management and Sharing Plan for: Mucus Swelling in the HEMT Era
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: A Hybrid Effectiveness-implementation Trial to Integrate Precision Skin Cancer Risk Feedback in Federally Qualified Health Centers
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data