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Data Management and Sharing Plan for: Sickle Cell Disease and Cardiovascular Risk- Red Cell Exchange SCD-CARRE
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Mathematical modeling of cellular signaling systems
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Monocyte-derived IL-10 drives sex differences in pain duration
No full textWomen frequently experience longer-lasting pain than men, indicating delayed pain resolution. While
we understand that pain can be orchestrated by the close interplay between the sensory nervous system and the
immune system, it remains unclear whether this interaction contributes to the longer duration of pain in women.
Here, we demonstrate that interleukin (IL)-10+ monocytes resolve inflammatory pain by signaling to IL-10R1+
sensory neurons in a mouse model of skin inflammation. A higher number of IL-10+ monocytes in males enables
faster resolution of inflammatory pain compared to females. In both sexes, pain resolution was impaired by
deleting Il10 from monocytes or Il10ra from sensory neurons. Similarly, in humans, men’s pain resolved faster
than women’s after traumatic injury, which was associated with higher levels of circulating monocytes and IL-10
in men. In mice, androgen signaling promotes IL-10 production by monocytes, resulting in sex differences in the
number of IL-10+ monocytes. Enhancing IL-10+ monocytes in the inflamed skin through Resolvin D1 treatment
accelerated pain resolution in both sexes of mice. Our findings uncover a novel role for peripheral IL-10+
monocytes in driving sex differences in pain resolution. These results reveal a previously underappreciated
contribution of immune cells to resolving pain and preventing the transition to chronic pain
Data Management and Sharing Plan for: SBIR: Development of a web-based platform implementing novel Predictor of Toxicity for Medical Devices (PredTox/MD)
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Enhancing HIV prevention and reducing alcohol use among people receiving STI care in Malawi: An HIV status neutral approach
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Duke-UNC Eastern North Carolina and Southern Virginia Regional Stroke Trial Consortium (ENVISION)
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Data Management and Sharing Plan for: Dissecting the heterogeneity of oral cancer pain
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data
Participant Assessments & Demographics, All Network Sites, Early Learning Network
No full textThe Early Learning Network is a collaboration of 6 research sites that investigated the impact of policy and practices, identified malleable factors associated with early learning and achievement, and developed tools to assess early learning instruction, interactions, and environments. This longitudinal research study (2016-2024) collected semi-structured interviews, survey data, observations, and content analysis of policy documents.
This record includes data from children, classroom/school, teacher, and families, gathered from observations and assessments, at all 6 sites in the Early Learning Network
Data Management and Sharing Plan for: Rechargeable Anti-thrombogenic Films for Blood Contacting Applications
No full textThe Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project data