International Medical Publishing Group(IMPG), India
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Lactulose induced warfarin toxicity- an interesting drug interaction
Get PDFWarfarin one of the most commonly used anticoagulants in the world is affected by the vitamin Klevels in the body, which in turn depends upon many factors like drugs and diet. Here we presenta case of a drug interaction between 2 commonly drugs especially in the elderly population. Inthis case Lactulose interacts with absorption of vitamin K from the gut and thereby potentiatingthe effect of warfarin toxicity. Hence it is important for every physician to be aware of this druginteraction and warn their patients regarding the same
DENTAL MANAGEMENT OF BETA THALASSEMIA MAJOR PATIENTS: A REVIEW
Get PDFBeta Thalassemia Major is a hereditary hemoglobinopathy that can take on different clinical expressions, with intense and multiple orofacial manifestations.It’s a major public health problem and a challenging condition that requires a multidisciplinary approach involving health practitioners from different paths (hematologist, dentist, orthodontist, cardiologist etc).The changes to the maxillofacial region stemming from this genetic form of anemia, makes it an obligation for dental practitioners to have in depth knowledge towards the nature of this disorder, its effects on oral health, and better understanding of the proper management of beta thalassemic patients.The purpose of this paper is to provide the dentist with a simplified understanding of the physiopathology of the disease, its various systemic and orofacial manifestations, and the keys to a better dental approach. Until medical research is able to provide a definitive solution to these diseases, through gene therapy or otherwise, it is necessary to welcome these patients into the cycle of dental care and offer them the most possibly complete dental experience through coordinated team work
REFERENCE VALUES OF HEMATOLOGICAL PARAMETERS INHEALTHY POPULATION IN MOROCCO
No full textOur study aims to determine the reference values of the CBC in an adult and healthy moroccan population. This is a studyof 996 cases including 874 men and 122 women whose samples were analyzed by the Coulter LH 750 controller thenentered and analyzed by SPSS statistical software. The reference values obtained for the main parameters are: GB between5,10x109- 11,58 x 109/L for women and 4,60 x 109- 13,81 x 109/L for men, PNN between 2,05 x 109 – 9,46 x 109/L forwomen and 1,60 x 109 – 9,80 x 109/L for men and the LYM between 0,42 x 109 – 4,18 x 109/L for women and 0,59 x 109– 4,41 x 109/L for men. The HB between 10.10 to 16.97 g / dL for women and 13.8 to 20.21 g / dL for men, PLQ between121,13 x 109 - 341,00 x 109/L for women and 108,00×109-327,25 x 109 /L for men. Comparing our results with those ofliterature or other studies revealed the existence of several dissimilarities. They are mainly due to ethnicity, smoking andhabits of individuals. This preliminary study has achieved the baseline blood counts for a Moroccan sample and detectspotential differences among populations, often involving diagnostic decisions; hence the need for the establishment of ourown intervals reference through more extended studies in different regions of Morocco. This must be done under theresponsibility of the health authorities and the values obtained must be validated to be applied to the disparities revealed byour study
HEMOPHAGOCYTIC SYNDROME, A RETROSPECTIVE STUDY INTHE MILITARY HOSPITAL MOHAMED V RABAT MOROCCO
Get PDFHemophagocytic Syndrome (HS) is an aggressive and life-threatening syndrome of excessive immune activation. It ismostly associated with underlying pathology, it can reveal: immunodeficiency, infections, cancers and auto-immunediseases.Objective of work: Identify the clinical, biological, etiological and evolutionary features of the HLH.Methods: A retrospective study of patients with HS syndrome collected in the Hematology Laboratory of the Mohamed VMilitary Hospital Rabat (MVMHR) in Morocco (between 2013 and 2015).Results: We identified 7 cases, 4 males and 3 females, middle aged 46 years. The onset of symptoms was brutal in allpatients. The splenomegaly and the inflammatory syndrome were found in all cases. The pancytopenia was observed in 6patients. The hemophagocytosis in bone marrow smear examination was found in all cases. There were infectiousunderlying causes in 4 cases: one case of visceral leishmaniasis, one case of Staphylococcus aureus sepsis, one case ofEscherichia coli sepsis and one case of glandular tuberculosis. For the other patients, there was a case of follicularlymphoma, a case of Hodgkin lymphoma and a case of myelodysplastic syndrome. The outcome was favorable in 3 cases, 4patients died
BONE MARROW BIOPSY PICTURE IN A PATIENT WITHMARFANOID HABITUS AND ANOREXIA NERVOSA
Get PDFGelatinous marrow transformation (GMT) is a rare disorder of bone marrow characterized by deposition of extra cellulargelatinous material. There is atrophy of the marrow adipocytes and loss of hematopoietic elements. It is also called asosseous atrophy of the bone marrow. It is not a specific disease but it is seen associated with chronic illness likemalnutrition, anorexia nervosa, HIV infection and administration of cytotoxic drugs. Here, we report a case of gelatinoustransformation of bone marrow in a 17 year old female presented with severe weight loss and anemi
Genesis of Psychopathogy in epileptics
Get PDFChildren suffering from epilepsy have been found to be strikingly susceptible to psychiatric disorders and almost all forms of such abnormalities have been reported in them. Except for a few,most studies on epilepsy concern adults. Nearly half of the children from the subject group had at least some psychiatric disturbance. Incomparison only one fourth of the children from the control group displayed any psychiatric disturbance. The most common psychiatric problem in the epileptic child was conduct disorder followed by a lowered intelligence, whereas in the non epileptic child anxiety and conduct disorder was common. Various factors were found to be significantly associated with psychopathology, these were either contributory to the epilepsy or were consequent to the epileptic state along with its biological, psychological and social ramifications. Thus, psycho-pathology reflected a complex interaction of seizures, socio-demographic factors and treatment related variables, in accord with studies. Clinicians should be sensitive in identifying psychopathology since this may lead to effective interventions for this group of children
Histopathological Spectrum of Endometrium in DysfuctionalUterine Bleeding With Respect to Age, Parity and Bleeding Pattern
Get PDFThe largest incidence of DUB is in the women of the childbearing age group and menorrhagia was more common in that age group. It is classified into: Anovulatory (90%) and ovulatory DUB (10%). This study includes 190 cases clinically diagnosed as DUB who are attendingOPD or admitted during period of June 2005 to June 2008. Endometrial samples were fixed in 10% formalin and routine processing was done. Paraffin block sections were stained with H&E. The commonest age group was 31-40 years (45.26%) and is seen most commonly in the multiparous women (71.58%). Menorrhagia was the commonest bleeding pattern found in 139 (73.16%) cases. No age was exempted from DUB. Menorrhagia was the commonest bleeding pattern. Endometrial hyperplasia and proliferative endometrium are the commonest endometrial patterns observed
Toxicity assessment of Aluminium on vermicomposting ability of Eudrilus eugeniae (Kinberg) on leaf litter
Get PDFVermicomposting technology is one of the best options available for the treatment of organics-rich solid wastes. In which earth worm converts biodegradable garbage into high quality manure and plays a key role in soil biology and they serve as versatile natural bioreactors to harness energy and destroy soil pathogens. The worms feed voraciously on all biodegradable wastes. There is an instance of chemical toxicity among non target organisms like earthworms etc, in agricultural lands due to pollution of chemical com-panies and factories. In the present investigation vermicomposting ability of earthworms Eudrilus eugeniae were measured experimentally by exposing in moist leaf litter with Aluminium. The morphological changes observed during the exposure of animals were observed in laboratory conditions and appears to impair the different stages of reproductive cycle of the worms thereby resulting in the onset of reduced vermicomposting ability of the earthworm.B
Gymnema sylvestre – A Key for Diabetes Management – A Review
Get PDFTraditional medicines derived from medicinal plants are used by about 60 per cent world population. Diabetes is an important human ailment officiating many from various walk of life in different countries including India. It providing to a major health problem, especially in the urban area: Gymnema sylvestre R.Br. (Asclepiadaceae) is a herb distributed throughout the world. The leaves of the plant are widely used for the treatment of diabetes and as diuretic in India proprietary medicine. G. sylvestre, an Ayurvedic herb, came to be known as “destroyer of sugar” because, in ancient times, Ayurvedia physicians observed that chewing a few leaves of G. sylvestre suppressed the taste of sugar. It is used totally all over India for controlling blood sugar. Several bio-active compounds have been isolated from the herb for diabetes care. It is believed to be used in dyspepsia, constipation, jaundice, haemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A scrutiny of literature revealed some notable pharmacological activities of the plant such as anti diabetic, antiobesity, hypolipidaemic, antimicrobial, free radical scavenging and antiinflam-matory. The present review is an attempton various ethanobotanical and traditional uses, phytochemical and pharmacological approaches of G. sylvestr
Isolation, Characterization and Identification of PotentialProbiotics from Fermented Tender Coconut Water
Get PDFTender Coconut Water is a refreshing beverage that comes from tender coconuts. It is a powerhouse of nutrition containing a complex blend of vitamins, minerals, amino acids, carbohydrates, antioxidants, enzymes, health enhancing growth hormones, and other phytonutrients. History and folklore credit coconut water with remarkable healing powers, which medical science is now confirming. Published medical research and clinical observation have shown that coconut water, Makes an excellent oral rehydration sports beverage; Aids in exercise performance; Reduces swelling in hands and feet; Aids in kidney function and dissolves kidney stones; Protects against cancer; Helps balance blood sugar; Provides a source of ionic trace minerals; Improves digestion; Contains nutrients that feed friendly gut bacteria (Fife, 2007). Within India the demand for tender coconut water has been increasing over the years. Of the total production of coconut in India, nearly 20 per cent is harvested in tender form, which was only 5 per cent in 2000. At present about 3200 million tender coconuts are consumed annually in India. In a metro city like Mumbai, the annual tender coconut turnover handled by some 40-50 wholesalers is estimated to be around Rs. 750 million. The nutrient content of fresh and fermented tender coconut water was identified. Identification of microorganism was done on fresh tender coconut water and fermented tender coconut water.Standardization of the fermented tender coconut water was done. The formulated drink was tested for its antimicrobial property with E.coli, Salmonella typhi and Enterococcus faecalis and it was seen that it hadgood effect. The pH of the fermented tender coconut water was found to be 3.98 and the alcohol percentage 2.91 %. Sensory evaluation was done for the fermented tender coconut water in combination with fruit juices in the ratio 1:1 and it was rated as good on a score of 5 by the panel members. Therefore fermented tender coconut water is a nutritious drink that has good acceptability and palatability. It is an easy to prepare fermented drink which has potential probiotics in it which is good for the gut