Universität Innsbruck - Data Repository
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Enzyme-responsive delivery: a robust approach to enhance endolysins' efficacy against Staphylococcus aureus biofilm
No full text<p>This poster was presented as an oral one minute presentation at Zukunft Pharmazie 2023.</p>
Data for Towards Detection of FeH+ in the Interstellar Medium: Infrared Multiple Photon Dissociation Spectroscopy of Ar2FeH+.
No full text<h2>A primer on your dataset's description (to be edited)</h2><p>The influence of proper documentation on the reusability for research data should not be underestimated!<br>In order to help others understand how to interpret and reuse your data, we provide you with a few questions to help you structure your dataset's description (though please don't feel obligated to stick to them):</p><h3>Context and methodology</h3><ul><li>What is the research domain or project in which this dataset was created?</li><li>Which purpose does this dataset serve?</li><li>How was this dataset created?</li></ul><h3>Technical details</h3><ul><li>What is the structure of this dataset? Do the folders and files follow a certain naming convention?</li><li>Is any specific software required to open and work with this dataset?</li><li>Are there any additional resources available regarding the dataset, e.g. documentation, source code, etc.?</li></ul><h3>Further details</h3><ul><li>Is there anything else that other people may need to know when they want to reuse the dataset?</li></ul>
Data archive for "Measuring Neoliberal Individualism, Instrumentality, and Competition: Development and Validation of the Neoliberal Ideological Beliefs Questionnaire (NLBQ)"
No full text
Data supporting article Thiolated Hyaluronic Acid: A Gateway for Targeted Killing of Staphylococcus aureus on ´the Race for Surface´ Colonization
No full text<h2>Description</h2>
<p><strong><span>Abstract</span></strong><span>: Hyaluronic acid (HA) is degraded by Staphylococcal hyaluronate lyase (Hysa) and mammalian hyaluronidase (Hyal). We aim to use thiolated HA (HAMS) as a targeted gateway for <em>Staphylococcus aureus</em> killing while enhancing our previous M23 endolysin–polyphosphate (M23-PP NPs) enzyme-responsive nanoparticle formulation.</span></p>
<p><span>Synthesis of HAMS and characterization for nuclear magnetic resonance, solubility, thiol content, pKa, and degradation by Hysa and Hyal is presented. Nanoparticles prepared via ionotropic gelation between M23-PP NPs and either HAMS or HA, yield to M23-PP/HAMS or M23-PP/HA NPs, respectively. Their characterization includes size, zeta potential, morphology, release profiles, safety, targeted release, and efficacy.</span></p>
<p><span>HAMS with a thiol content of 250.18 ± 90.32 µmol/g, solubility of 50.99±0.02 mg/mL, exhibits pKa values of 3.2, 4.2, and 8.8. This thiolated polymer irreversibly inhibits Hyal activity, without affecting Hysa. M23-PP/HAMS NPs (265 ± 47 nm, -25 mV) maintain their integrity for seven days at 37 °C, and HAMS coating prevents nonspecific degradation by Hyal, as confirmed by release studies.</span></p>
<p><span>In a co-culture ‘race for the surface’ experiment with MC3T3 osteoblasts and <em>S. aureus</em> ATCC 25923, M23-PP/HAMS NPs produce 8-log bacterial killing while promoting <em>in vitro</em> wound healing. </span></p>
<p><span>Our findings are pivotal to the development of new enzyme-responsive excipients switchable by <em>S. aureus</em>.</span></p>
<h3>Context and methodology</h3>
<ul>
<li>This dataset was created on the frame of NanoBioRS project European Union's Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie IF [NanoBioRS-101025065].</li>
<li>This dataset corresponds to raw data underlying the publication Thiolated Hyaluronic Acid: A Gateway for Targeted Killing of Staphylococcus aureus on ´the Race for Surface´ Colonization </li>
<li>This dataset was generated through experimental work focused on the use of thiolated hyaluronic acid (HAMS) as a switch for the targeted delivery of polyphosphate nano encapsulated peptidoglycan hydrolase M23 (M23-PP)</li>
</ul>
<h3>Technical details</h3>
<ul>
<li>For naming the samples comprising M23-PP coated with HAMS, a logical system was applied and was maintained across all the publications related with this dataset. </li>
<li>This dataset can be opened using Microsoft Excel, a part of the Microsoft Office suite</li>
<li>This dataset was published and is associated to a DOI</li>
</ul>
<h3>Further details</h3>
<ul>
<li>For further reference, please read Thiolated Hyaluronic Acid: A Gateway for Targeted Killing of Staphylococcus aureus on ´the Race for Surface´ Colonization </li>
</ul>
Facet-Dependent Restructuring and Catalytic Activity of Cu Single Crystals during CO Electro-Oxidation
No full text<p>Raw data for the publication DOI: <a title="DOI URL" href="https://doi.org/10.1021/acsnano.5c13881">https://doi.org/10.1021/acsnano.5c13881</a></p><p>Understanding the relationship between surface structure and catalytic activity is central to the rational design of efficient electrocatalysts. While Cu is well-known for its tendency to restructure under reaction conditions, it remains poorly understood how exactly such dynamic structural changes influence the catalytic activity. Here, we combine electrochemistry with <em>in situ</em> electrochemical scanning tunneling microscopy (EC-STM) to study and directly compare CO electro-oxidation on Cu(111) and Cu(100) single crystals and how it relates to the structural changes on these two faces.</p>
<p>We find that both surfaces undergo nanometer-scale restructuring during the reaction, leading to the formation of undercoordinated Cu adatoms, which act as the catalytically active sites for both surfaces. However, their morphological evolution differs markedly: Cu(111) exhibits dynamic and reversible restructuring, maintaining a high density of adatom nanoclusters across successive potential steps, whereas Cu(100) forms clusters that evolve less reversibly, with a gradual decrease in cluster density over time and upon repeated potential steps. Notably, the evolution of clusters and their density does not directly correlate with the observed catalytic activity for either facet. Instead, we propose that the facet-dependent differences in activity stem primarily from variations in the effective density of the catalytically active Cu adatoms and their distinct interaction with reactants, rather than from different structural motifs.</p>
<p>These findings highlight the crucial role of dynamic surface restructuring in governing catalytic performance and emphasize the need to account for facet-specific morphological and structural changes in the rational design of efficient Cu-based electrocatalysts.</p>
Intermediate scattering function of colloids in a periodic laser field
No full text<h2>Abstract</h2>
<p>We investigate the dynamics of individual colloidal particles in a one-dimensional periodic potential using the intermediate scattering function (ISF) as a key observable. We elaborate a theoretical framework and derive formally exact analytical expressions for the ISF. We introduce and analyze a generalized ISF with two wave numbers to capture correlations in a periodic potential beyond the standard ISF. Relying on Bloch's theorem for periodic systems and, by solving the Smoluchowski equation for an overdamped Brownian particle in a cosine potential, we evaluate the ISF by numerically solving for the eigenfunctions and eigenvalues of the expression. We apply time-dependent perturbation theory to expand the ISF and extract low-order moments, including the mean-square displacement, the time-dependent diffusivity, and the non-Gaussian parameter. Our analytical results are validated through Brownian-dynamics simulations and experiments on 2D colloidal systems exposed to a light-induced periodic potential generated by two interacting laser beams.</p>
<h2>Experimental data </h2>
<p>The raw experimental data, used in the paper can be found here: <a href="https://zenodo.org/records/14931759">Intermediate scattering function of colloids in a periodic laser field</a></p>
Two-dimensional diboron trioxide crystal composed by boroxol groups
No full text<p><strong><span>Authors:</span></strong><span> T. Zio<sup>1,2</sup>†, M Dirindin<sup>2</sup>†, C. Di Giorgio<sup>1</sup>, M. Thaler<sup>3</sup>, B. Achatz<sup>3</sup>, C. Cepek<sup>1</sup>, I Cojocariu<sup>2,4</sup>, M. Jugovac<sup>4</sup>, T. O. Mente</span><span>ş</span><sup><span>4</span></sup><span>, A. Locatelli<sup>4</sup>, L. L. Patera<sup>3</sup>, A. Sala<sup>1</sup>*, G. Comelli<sup>1,2</sup>, M. Peressi<sup>2</sup>*, C. Africh<sup>1</sup></span></p>
<p><strong><span>Affiliations:<span> </span></span></strong></p>
<p><sup><span>1</span></sup><span>CNR – Istituto Officina dei Materiali (IOM); Basovizza, Trieste, 34149 Italy.</span></p>
<p><sup><span>2</span></sup><span>Department of Physics, University of Trieste; Trieste, 34127 Italy.</span></p>
<p><sup><span>3</span></sup><span>Department of Physical Chemistry, University of Innsbruck; Innsbruck, 6020 Austria.</span></p>
<p><a name="_Hlk62201618"></a><sup><span>4</span></sup><span><span>Elettra Sincrotrone Trieste S.C.p.A; Basovizza, Trieste, 34149 Italy.</span></span></p>
<p><a name="_Hlk62201654"></a><span>*Corresponding author. Email: </span><a title="mailto:[email protected]" href="mailto:[email protected]"><span><span>[email protected]</span></span></a><span><span> (experiment), </span></span><a title="mailto:[email protected]" href="mailto:[email protected]"><span><span>[email protected]</span></span></a><span><span> (theory).</span></span></p>
<p><span>†These authors contributed equally to this work<a name="_Hlk62201691"></a>.</span></p>
<p> </p>
<p><strong>Abstract</strong><br>Diboron trioxide (B2O3) represents an unusual case among polymorphic oxides, for its vitrified state features superstructural units – planar boroxol groups – that are never observed in its three-dimensional crystalline polymorphs. Crystalline polymorphs that incorporate boroxol groups have only been predicted theoretically, although their formation is crucial to rationalize the ability of B2O3 to vitrify. Here we present the synthesis of a two-dimensional crystalline B2O3 polymorph constituted by boroxol groups arranged in an atomically thin honeycomb lattice. By combining surface science experimental techniques with ab initio<em> </em>calculations, we characterize the structural and electronic properties of this B2O3 polymorph down to the atomic level. This discovery enlarges the family of two-dimensional materials and enables the atomic tracking of individual structural units in trioxides.</p>
<p> </p>
<p><strong>Dateset:</strong> https://doi.org/10.24435/materialscloud:e1-bf</p>
MS_XevoTQXS_2024_July
No full text<p>MHO03BZ - Tuftsin - Postina<br>Standards - ADMA, SDMA<br>ASE05AH</p>
Experimental data of structural tests on non-continuously stiffened steel panels subjected to uniform compression
No full text<p>This dataset consists of data related to the experimental investigations of 50 non-continuously stiffened steel panels subjected to uniform compression (20 open-section, 30 closed-section specimens). The results and discussion associated with this dataset have been published as an open access article in the Journal of Thin-Walled Structures and can be accessed via this link: https://doi.org/10.1016/j.tws.2023.111260</p>
<p> </p>
<p><strong>OVERVIEW:</strong></p>
<ul>
<li>specimen_naming.pdf - Graphical explaination of the the specimen naming</li>
<li><strong>01_overview_results_specimen </strong>- one-page overview of all relevant test results for each specimen</li>
<li><strong>02_tensile_coupon_test</strong> - XLSX-files (including engineering stress-strain and Cauchy stress-strain). <br>
<ul>
<li>open sections: coupon tests for the plates, stiffener webs and stiffener flanges</li>
<li>closed sections: test certificates + random controls (10x plate, 10x stiffener)</li>
</ul>
</li>
<li><strong>03_geometric_imperfection_data</strong> - STL-files (cleaned from outliers and centered to COS).</li>
<li><strong>04_test_result_data </strong>- CSV-files (compare associated paper for placements of LVDTs)</li>
</ul>