Hatay Mustafa Kemal Üniversitesi Akademik Veri Yönetim Sistemi
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DNA ve Genetik Kod ünitesinin öğretiminde EGS Tabanlı Öğretimin Etkisi
No full textBu araştırmanın amacı, 8. sınıf öğrencilerine DNA ve Genetik Kod ünitesinin öğretiminde EGS tabanlı öğretimin etkisini ve fene yönelik tutumunu incelemektir. Araştırma, karma araştırma deseni ile yürütülmüştür. Nicel veri analizi için ön test-son test kontrol gruplu yarı deneysel desen kullanılmıştır. Araştırmanın nicel verilerini güçlendirmek amacıyla da nitel araştırma yönteminden yararlanılmıştır. 2024-2025 eğitim öğretim yılı içerisinde yapılan bu araştırmanın örneklemini İstanbul ilinin Beyoğlu ilçesinde öğrenim gören 41 sekizinci sınıf öğrencisinden oluşmaktadır. Bu 41 öğrencinin 21’i deney grubunu ve 20’si de kontrol grubunu oluşturmaktadır. Deney grubunda dersler EGS Tabanlı öğrenme ile kontrol grubunda ise dersler Fen Bilimleri Öğretim Programının ön gördüğü bir şekilde MEB ders kitabına bağlı kalarak dersler yürütülmüştür. EGS Tabanlı Öğretim uygulamaya başlarken deney grubu öğrencilerine DBT (Durum Belirleme Testi) uygulanarak etkileşim basamağı tamamlanmıştır. Ardından öğrencilere yıllık plan takvimine göre problem durumları verilerek deney grubu öğrencilerinin bunlara çözüm üretmesi istenmiş ve gereklilik basamağı uygulanmıştır. Devamında ise deney grubundan bireysel öğrenci raporları istenerek sorulara ürettikleri çözümleri yazmaları istenmiştir ve böylelikle sorgulama basamağı uygulanmıştır. Yapılan bu araştırma toplamda 8 hafta sürmüştür. Öğrencilerin akademik başarılarını ölçmek amacıyla “Başarı Testi” kullanılmış, tutum davranışlarını ölçmek için de “Fene Yönelik Tutum Ölçeği” kullanılmıştır. Normal dağılım gösteren FYTÖ verileri analiz edebilmek için T-Testi, normal dağılım göstermeyen başarı testi için Wilcoxon İşaretli Sıralar Testi ve Wann-Whitney U Testi kullanılmıştır. Yapılan istatistiksel analizler hem deney grubu hem de kontrol grubu öğrencilerinin verilerine uygulanmıştır. Fakat gözlem sadece deney grubunda EGS Tabanlı uygulamanın Gereklilik basamağında kullanılmıştır. Sonuç olarak DNA ve genetic kod öğretiminde kontrol grubuna kıyaslanarak, uygulanan EGS Tabanlı Öğrenmenin deney grubu öğrencilerin akademik başarılarını arttırdığı, düşünme yollarını ve anlama şekillerini geliştirdiği sonucuna varılabilir. Fakat EGS Tabanlı Öğrenmenin öğrencilerin fene yönelik tutumunu geliştirdiği sonucuna varılamamaktadır. Bu noktada fen bilimleri dersinde daha farklı konularda ve farklı yaş gruplarında öğrencilerin düşünme yollarında ve anlama şekillerini olumlu anlamda geliştirebilmek amacıyla EGS Tabanlı Öğrenmenin uygulanması önerilebilir. </p
The effects of digital games on pain, fear, anxiety, and physiological responses in children during port catheter needle insertion: A randomized controlled study
No full textPurpose This study examined the effect of playing a digital game during port catheter needle insertion on pain, fear, anxiety, and physiological responses in children aged 6–12 years undergoing chemotherapy. Methods This randomized controlled trial was conducted with 56 children in a pediatric hematology-oncology unit. Participants were randomly assigned to the experimental group, which played a digital game via an online platform during the procedure, or to the control group, which received standard care. Data were collected using the Demographic Form, Wong-Baker Faces Pain Rating Scale, Children's State Anxiety Scale, and Children's Fear Scale. Results Children in the experimental group reported lower pain and anxiety compared to controls, with mean post-procedure anxiety scores of 1.61 ± 0.737 versus 2.32 ± 1.634 (p = 0.049). Fear levels decreased significantly in both groups (p 0.05). Conclusions This study highlights the efficacy of digital games in reducing pain, fear, and anxiety in children with port needles, as well as in stabilizing heart rate. Consequently, it is recommended that digital games be incorporated into clinical practice as an effective distraction method for pediatric patients during invasive procedures. This study has significant implications for nursing practice, demonstrating that digital games are a cost-effective, accessible, and child-friendly non-pharmacological intervention. By reducing distress and enhancing coping, digital games can be integrated into routine nursing care to improve children's experiences and foster trust in clinical settings
Efficacy and tolerability of tenofovir alafenamide fumarate prophylaxis in HBV-infected individuals receiving chemo/ immunosuppressive therapy
No full textBackground and Aim: This study aimed to determine the efficacy and safety of tenofovir alafenamide fumarate (TAF) prophylaxis in hepatitis B virus (HBV)-infected or HBV-experienced individuals with benign and ma-lignant diseases receiving chemo/immunosuppressive or biological modifier therapy. Materials and Methods: This is a multicenter, observational study in which data from 13 centers were reviewed and entered into a standardized electronic case report form. Results: A total of 158 individuals who received TAF prophylaxis were included in the analysis. Before starting the prophylaxis, 51 individuals were hepatitis B surface antigen positive, while 107 were HBV-experi-enced. Thirty patients had detectable HBV DNA levels. Twelve of them had abnormal serum alanine aminotransferase levels. Forty patients were switched to TAF. Solid tumors (34%) were the most common primary disease types. The median follow-up period was 17.2 months. From baseline to the end of the follow-up period, none of the patients had clinical, biochemical, or serological evidence of HBV reactivation under TAF prophylaxis. The virological response rate was 87%. HBV suppression was well maintained after switching in the 40 patients who were switched to TAF treatment. All patients maintained their chemo/ immunosuppressive therapy without interruption. TAF prophylaxis was well tolerated. No drug discontinuation due to adverse effects was observed. No HBV-related morbidity or mortality was observed during the TAF prophylaxis. No significant differences were found in the glo-merular filtration rate change or hypophosphatemia during TAF pro-phylaxis, but the serum triglyceride levels were significantly increased (p=0.019). Conclusion: TAF prophylaxis is effective, safe, and tolerable in preventing chemo/immunosuppressive or biological modifier-induced HBV reactivation in HBV-infected or HBV-experienced individuals
Non-contact acoustic screening for sleep apnea: a subject-aware deep learning approach
No full textPurpose: To explore the feasibility of using camera-derived, non-contact audio synchronized with PSG for clinically relevant sleep-apnea classification, and to benchmark compact deep models under a subject-aware design using a previously unstudied, real-world dataset. Methods: Thirty-two adults underwent simultaneous polysomnography (PSG) and camera-based non-contact audio recording. The synchronized audio segments were used to train and compare three compact deep-learning architectures (convolutional, attention-augmented, and transformer-based) under a subject-aware evaluation design that prevented identity leakage. Model performance and calibration were assessed at both segment and subject levels using standard statistical tests. Results: Subject-level evaluation was based on a very small, imbalanced test set of six subjects (one positive). Within this limited yet previously unstudied local dataset, the CNN_trans model achieved an apparent perfect ranking performance (AUC = 1.00; 95% CI 0.00–1.00), though this likely reflects the small, imbalanced test cohort, with recall = 1.00 and precision = 0.55. The wide confidence interval reflects substantial statistical uncertainty, and DeLong comparisons showed no significant AUC difference between CNN_trans and CNN_att (ΔAUC = − 0.042; p = 0.43). Conclusion: PSG-synchronized, non-contact audio supports accurate and well-calibrated sleep-apnea classification with compact deep models. This subject-aware evaluation suggests that contactless acoustic monitoring may have potential clinical relevance, motivating larger, multi-site validation
GUT HASTALARINDA KORNEA ENDOTEL HÜCRE MORFOLOJİSİ VE RETİNA İLE OPTİK SİNİR MİKROSİRKÜLASYONUNUN DEĞERLENDİRİLMESİ
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Morphological Structure of Vomeronasal Organ in Akkaraman, Morkaraman, and Tuj Sheep
No full textThis study examined the vomeronasal organs (VNOs) obtained from the heads of two Akkaraman sheep, two Morkaraman sheep and four Tuj sheep. The animals studied were female and 1.5 years old. The aim of this study was to describe the anatomical and histochemical features of the VNO in Akkaraman, Morkaraman, and Tuj sheep breeds. It was determined that the VNO was oval-shaped and tubular in these breeds. In general, the right VNO was longer in all three breeds of sheep. In the cranial sections of the VNO, which is located in the form of a pair of blind tubes at the base of the nasal septum, the entire epithelial layer is rostrally lined with non-sensory epithelium. However, moving caudally, sensory epithelium begins to appear along the medial wall of the VNO. The caudal sections of the VNO had no serous vomeronasal glands. A small number of mucous glands were observed within the lamina propria of the VNO. The VNO of the Akkaraman sheep was found to have more mucous glands than those of the other two breeds of sheep. While the hyaline VN cartilage surrounding the lamina propria was intact rostrally, it was observed that the cartilage opened in the dorsal region. The ring structure was disrupted and the cartilage adopted a J-shape. As it moved caudally, the cartilage closed again from the dorsolateral region. In conclusion, the goblet cells in the non-sensory pseudostratified columnar epithelial tissue located in the lateral lamina epithelialis of the VNO showed strong PAS (+) and AB (−) staining characteristics. While the VN glands were generally considered serous, it was observed that most gland cells showed strong PAS (+) staining characteristics, while a few were weak AB (+) and most were AB (−). Mucous glands, which were fewer in number, were negative for both PAS (−) and AB (−). Both PAS and AB staining showed positive (+) staining characteristics for the VN cartilage. In conclusion, the anatomical and histological structure of the VNO in Akkaraman, Morkaraman, and Tuj sheep was examined and compared with findings from other studies on this subject in different animal species.</p
Fatty acid composition in the yolk and yolk sac, embryo development, IGF-I and VEGF-A gene expressions and hatching results in eggs obtained from local and commercial breeders
No full textThis study investigated fatty acid composition in yolk and yolk sac, embryo development, IGF-I and VEGF-A gene expressions, and hatching results in eggs from local (Denizli and Gerze) and commercial (broiler (ROSS-308 and layer (Hy-Line W-80) breeders. A total of 1032 eggs per genotype were incubated. Eggs were weighed, numbered, and sampled at the beginning and on days 10, 13, 16, and 19 for yolk, embryo, fatty acid, and gene expression analyses. At hatch, all chicks were weighed, and eight per genotype were sampled for fatty acid composition in the residual yolk sac and gene expression in breast muscle. Significant genotypic differences were found in egg and chick weights, with layer hybrids having the greatest (59.68 and 41.13 g, respectively) and Gerze the lowest values (52.22 and 36.40 g, respectively). Relative embryo weights increased during incubation, with broilers showing the greatest values and local breeds having higher residual yolk sac weights. While chick weights differed, relative chick weights did not vary significantly. Fertility, embryonic mortality, and hatchability were affected by genotype; hybrids had higher fertility and hatchability, whereas Gerze showed the greatest embryonic mortality and lowest hatchability (11.23 and 67.76%, respectively). Fatty acid profiles showed palmitic (approximately 24–25%) and stearic acids (approximately 9–10%) as dominant saturated fatty acids, oleic acid (approximately 40–45%) as the main MUFA, and linoleic acid (approximately 15–20%) as the major PUFA. In terms of the IGF-1 gene, embryos of the Denizli breed were downregulated by 0.38 fold compared to laying hybrids while in chicks this change was found to be an 8.66 fold upregulation. It was determined that these values were downregulated by 0.08 fold in embryos and 0. 71 fold in chicks in terms of the VGEFA gene. PPI analysis of 32 IGF1/VEGFA interactors revealed a core module centered on FGFs, PGF, neuropilins, and VEGF receptors. Enrichment pointed to system development and angiogenesis, with MAPK, receptor tyrosinekinase, IGF1RIRS, and calcium signaling as key pathways. Genotypespecific differences in this signaling hub underscore the value of local breeds like Denizli for optimizing embryonic vascular and muscle development in sustainable poultry production
Konjonktürel dalgalanmaların fibonacci altın oran yaklaşımıyla ampirik analizi: Türkiye örneği
No full textThis study investigates the frequency-based structure of Turkey's business cycles using quarterly real GDP growth data from 1961 to 2024 and the Hodrick-Prescott (HP) filter. This study tested the hypothesis that successive cycle lengths converge toward the golden ratio (1.618) or its inverse (0.618). Methodologically, the series was normalized using a GARCH(1,1) model, dominant frequencies were identified via Fourier transformation, and cycle lengths were classified using a Gaussian mixture model before being projected via harmonic regression. Validation using the Harding and Pagan (2002) Concordance Index and phase synchronization analysis confirmed a high degree of alignment between the model and real growth data. The results indicate that short- and medium-term cycles cluster around the inverse of the golden ratio (0.618), suggesting that Turkish economic fluctuations are not random but are governed by regular structural rhythms that are aligned with historical turning points.</p
EGE BÖLGESİ’NDE YAĞIŞLARIN EĞİLİMİ (1938-2024)
No full textTürkiye, iklim değişikliğine karşı hassas bir konumda yer alır. İklim değişikliği, yalnızca sıcaklıklarda değil; yağışların üzerinde de etkilidir. İklim değişikliği; belirli bölgelerde yağış azlığına (kuraklık) neden olurken, diğer bölgelerde aşırı yağış olaylarıyla (sel ve taşkın) karakterize edilmektedir. Bu bağlamda, 1938-2024 yılları arasında Ege Bölgesi’nde yer alan il merkezi meteoroloji istasyon verileri kullanılarak yağışlarda meydana gelen eğilimler yıllık ve mevsimlik (İlkbahar, Yaz, Sonbahar, Kış) periyotlarda incelenmiştir. Çalışmada, Mann-Kendall Trend Analizi ve Sen Eğim Analizi yöntem olarak kullanılmıştır. Mann-Kendall Trend Analizi, iklim eğilimlerinin belirlenmesinde uygulanması kolay ve veri dağılımından bağımsız olması, eksik verileri tolere edebilmesi ve aykırı değerlere dayanıklılık açısından sıralı zaman serileri üzerinden analiz yapması nedeni ile literatürde oldukça sık kullanılır. Sen Eğim Analizi ile birim zamana bağlı değişimin miktarı belirlenir ve ileriye dönük bir çıkarımı mümkün kılar. Yapılan analize göre; Ege Bölgesi’nde kış yağışlarında anlamlı azalma eğilimlerinin görüldüğü, Sonbahar yağışlarında artma eğilimlerinin varlığı tespit edilmiştir. Bu durum, mevsimsel kayma olarak literatürde değerlendirilir. Yıllık periyotta da azalma eğilimleri dikkat çekicidir. Bölgenin su yönetiminin planlanabilmesi için yağış eğilimlerinin gözönünde bulundurulması gerekir.Türkiye is situated in a region highly vulnerable to the impacts of climate change. Climate change manifests not only through temperature fluctuations but also significantly influences precipitation patterns. While causing precipitation scarcity and drought in certain regions, climate change is characterized by extreme precipitation events, such as floods and overflows, in others. In this study, precipitation trends in the Aegean Region were examined for the period between 1938 and 2024. Utilizing data from meteorological stations located in provincial centers, trends were analyzed across annual and seasonal (Spring, Summer, Autumn, and Winter) periods. The Mann-Kendall Trend Test and Sen’s Slope Estimator were employed as the primary research methodologies. The Mann-Kendall Trend Test is widely utilized in the literature for determining climatic trends due to its ease of application, its non-parametric nature (independence from data distribution), its tolerance for missing data, and its robustness against outliers. Sen’s Slope Estimator was used to determine the magnitude of change per unit of time, allowing for forward-looking projections. According to the results of the analysis, significant decreasing trends were observed in winter precipitation in the Aegean Region, while increasing trends were identified in autumn precipitation. This phenomenon is classified in the literature as a "seasonal shift." Furthermore, decreasing trends in the annual period are noteworthy. These precipitation trends must be integrated into regional water management planning to ensure sustainable resource allocation.</p