Hatay Mustafa Kemal Üniversitesi Akademik Veri Yönetim Sistemi
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Microbial contamination of dental graft materials according to post-opening storage conditions: an experimental in vitro study
No full textAssessment And Evaluatıon Approach For The Harezmı Educatıon Model: A Grounded Theory Study
No full textAn exploratory study of behavioral, cognitive, physiological, and microbiota profiles in senior dogs
No full textIntroduction: Aging in dogs is a multifactorial process involving behavioral, cog-nitive, immunological, and microbiota-related changes, yet distinguishing healthyfrom pathological aging remains challenging. This exploratory study aimed toevaluate physiological indicators of health by integrating pain evaluation andcognitive testing in senior companion dogs.Methods: Eighteen companion dogs aged ≥8 years underwent standardizedbehavioral and cognitive evaluations (Mini C-BARQ, DISHAA, object choice test),chronic pain assessment (Helsinki Chronic Pain Index), and quality-of-life (QoL)scoring. Hematological parameters, serum brain-derived neurotrophic factor(BDNF), and Th1/Th2 ratios were measured as physiological indicators, whilefecal samples were analyzed via 16S rRNA sequencing for microbiota profiling.Results: All dogs scored above the chronic pain threshold (mean HCPI: 28.72),although caregiver-reported QoL ratings suggested good overall wellbeing.Cognitive testing yielded low average scores on the DISHAA (mean: 9.05), withonly one dog showing mild cognitive decline; however, mean performance onthe object choice test was low (1.94/5). Mean serum BDNF concentration was0.154 ng/dL (SD: 0.082) and correlated positively with red blood cell (RBC) countand negatively with MCV, MCH, and MCHC (p ≤ 0.05). Immune profiling patternssuggested Th2 polarization. The gut microbiota was dominated by Firmicutesand Bacteroidetes. Principal Component Analysis (PCA) identified two primarydimensions of biological variation: a pain–immune–microbiota axis, defined byhigher chronic pain scores, Th2 polarization, increased Prevotella abundance,and higher DISHAA scores, and a second component reflecting microbiota com-positional variation.Discussion: These preliminary findings highlight potential interactions betweenpain, microbiota composition, and immune dysregulation, suggesting their pos-sible utility as candidate indicators for differentiating healthy from pathologicalaging in dogs.Introduction: Aging in dogs is a multifactorial process involving behavioral, cog-nitive, immunological, and microbiota-related changes, yet distinguishing healthyfrom pathological aging remains challenging. This exploratory study aimed toevaluate physiological indicators of health by integrating pain evaluation andcognitive testing in senior companion dogs.Methods: Eighteen companion dogs aged ≥8 years underwent standardizedbehavioral and cognitive evaluations (Mini C-BARQ, DISHAA, object choice test),chronic pain assessment (Helsinki Chronic Pain Index), and quality-of-life (QoL)scoring. Hematological parameters, serum brain-derived neurotrophic factor(BDNF), and Th1/Th2 ratios were measured as physiological indicators, whilefecal samples were analyzed via 16S rRNA sequencing for microbiota profiling.Results: All dogs scored above the chronic pain threshold (mean HCPI: 28.72),although caregiver-reported QoL ratings suggested good overall wellbeing.Cognitive testing yielded low average scores on the DISHAA (mean: 9.05), withonly one dog showing mild cognitive decline; however, mean performance onthe object choice test was low (1.94/5). Mean serum BDNF concentration was0.154 ng/dL (SD: 0.082) and correlated positively with red blood cell (RBC) countand negatively with MCV, MCH, and MCHC (p ≤ 0.05). Immune profiling patternssuggested Th2 polarization. The gut microbiota was dominated by Firmicutes<span style="heigh
The Critical Role of Nutritional and Procedural Factors in CTO-PCI Patient Prognosis
No full text(1) Background: Chronic total occlusion percutaneous coronary intervention (CTO-PCI) is a complex, high-risk procedure compared to standard percutaneous coronary intervention (PCI). Scoring systems such as the Japanese Chronic Total Occlusion (J-CTO), European Chronic Total Occlusion (EuroCTO), and Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS-CTO) evaluate lesion difficulty and predict outcomes. Nutritional status, measured by the Prognostic Nutritional Index (PNI), may also affect procedural success and long-term survival. The objective of this study was to evaluate the combined impact of procedural complexity and nutritional status on the clinical outcomes of patients undergoing CTO-PCI. (2) Methods: We analyzed 118 patients undergoing CTO-PCI between May 2021 and March 2022. Procedural complexity was assessed using the J-CTO, EuroCTO, and PROGRESS-CTO scores, while nutritional status was evaluated using the PNI. Primary outcomes included all-cause mortality and repeat revascularization, which were analyzed using Cox proportional hazards regression and Kaplan–Meier survival analyses. (3) Results: Adverse outcomes occurred in 25 patients (mortality: 17; revascularization: 8). Patients with adverse outcomes had significantly lower left ventricular ejection fraction (LVEF) (46 ± 13.7% vs. 52.1 ± 10.5%, p < 0.001), lower PNI (p < 0.001), and higher J-CTO, EuroCTO, and PROGRESS-CTO scores (all p < 0.05). A PNI cut-off value of 46 predicted mortality with a sensitivity of 70.6% and specificity of 75.2% (area under the curve [AUC] = 0.739, p = 0.001). Multivariable analysis identified LVEF (hazard ratio [HR] 0.966, p = 0.036), J-CTO score (HR 1.598, p = 0.027), and PNI (HR 0.925, p = 0.022) as independent predictors of mortality. (4) Conclusion: Both procedural complexity and nutritional status significantly influence outcomes following CTO-PCI. Incorporating PNI together with procedural complexity scores into pre-procedural assessments may enhance risk stratification and optimize patient management
Electrolyzed water technologies in agri-food fields: From pesticide reduction to shelf-life extension and bioactive preservation
No full textIn recent years, the food industry has focused on sustainable and environmentally friendly technologies to improve food safety, quality, and efficiency while exploring innovative solutions. One such solution is electrolyzed water (EW). EW, produced by electrochemical separation of a dilute aqueous salt solution, has different properties at various pH levels. This review examines the potential applications of EW in the post-harvest handling of fruits and vegetables. These include I) effectively inhibiting microbial growth, II) reducing browning in produce, III) extending shelf life, IV) using a non-thermal method to remove pesticide residues, and V) potential uses in food extraction processes. The review also considers how combining EW with other technologies—such as ozone, ultraviolet light, ultrasound, and high-voltage electrostatic fields—can enhance quality control of fruits and vegetables. Overall, this review aims to fill gaps in current research by providing a comprehensive analysis of the latest advances in EW applications within the agri-food industry
SEASONAL FLIGHT ACTIVITY AND LARVAL INFESTATION OF Kermania pistaciella AMSEL (LEPIDOPTERA: TINEIDAE) IN PISTACHIO ORCHARDS OF GAZIANTEP PROVINCE, TÜRKİYE
No full textEvaluation of the Effect of Carving Materials Used in Dental Anatomy Courses on Students' Preferences and Performance
No full textIs the psychiatric symptom burden higher in individuals with post-earthquake tension-type headache?
No full textAKSİYEL TUTULUMLU PSÖRİYATİK ARTRİT HASTALARINDA ATLANTOAKSİYEL İNSTABİLİTE SIKLIĞI VE İLİŞKİLİ FAKTÖRLER
No full textAmaç: Psöriyatik artrit (PsA), aksiyel iskeletietkileyebilen kronik inflamatuvar hastalıktır. Atlantoaksiyel instabilite(AAİ), tüm inflamatuvar artritlerde önemli komplikasyondur ancak PsAolgularında AAİ monitörizasyonu konusunda konsensus yoktur. Çalışmamızda,aksiyel PsA olgularında AAİ sıklığını ve ilişkili faktörleri saptayarak bukonuda yol gösterici bilgiler sunmayı amaçladık.Materyal-metod: ‘CASPAR’ kriteriyle PsA olaraksınıflandırılmış ve ‘Calin’ kriterine göre aksiyel tutulumlu olarak değerlendirilmişerişkin PsA olguları tek merkezden çalışmaya alındı. Omurgayı etkileyebileninflamatuvar veya non-inflamatuvar hastalığı olanlar çalışmadan dışlandı.Elektronik hasta dosyaları retrospektif olarak incelendi. Lateral nötral/tamekstansiyon/tam fleksiyon ve ağız açık anteroposterior filmler AAİ lezyonlarınıdeğerlendirmek amacıyla hastalara kör üç romatolog tarafından okundu. Bulgular: Çalışmaya ortalama yaşı 48,8 yıl ve ortalamaPsA süresi 7,4 yıl olan ve %57’si kadın toplam 100 hasta alındı. Hastaların%18’inde toplam 20 adet AAİ lezyonu saptandı; subaksiyel subluksasyon(SAS) sekiz,anterior atlantoaksiyel subluksasyon (AAS) yedi, posterior AAS üç, lateral AASbir ve vertikal subluksasyon(VS) bir olguda saptandı. Atlantoaksiyelinstabiliteye sahip grupta psöriyasis(Ps) varlığı (p = 0, 037), skalp psöriyasisi(p < 0,001), Ps ve PsA için hedefe yönelik tedavi kullanımı(p < 0,001, p < 0,001) AAİ-negatif gruba göreanlamlı olarak daha yüksekti. Sonuç: Hedefe yönelik tedavi kullanan Ps ve PsA olgularıindirekt olarak konvansiyonel tedavilere dirençli ve yüksek hastalık aktiviteliolguları yansıtmalarından dolayı bu PsA olgularının AAİ açısından monitörizeedilmesi akılcı bir yaklaşım olabilir. Konuyu daha iyi aydınlatabilmek içinsensitif görüntüleme metodlarıyla yapılacak prospektif çalışmalara ihtiyaçvardır.</p
Wound healing activities of eucalyptol on full thickness excisional skin wound model in rats
No full textA plant-derived monoterpene, eucalyptol (1,8-cineole), has been suggested to have antioxidant, anti-inflammatory, and antimicrobial properties. The wound-healing effects of eucalyptol remain unknown. This study aimed to evaluate the topical use of eucalyptol at two concentrations on a full-thickness excisional skin wound model in terms of wound healing, gene expression, biochemical changes, and histopathological changes. Sixty Wistar rats were randomly divided into 5 groups (n = 12 per group). The control group (C) was untreated. Full-thickness excisional skin wounds were created in the following groups: the vehicle group (V), which was treated with polysorbate 80 solution (negative control). The Dexpanthenol group (D) was treated with dexpanthenol ointment (positive control). Eucalyptol 5% (E5) and Eucalyptol 10% (E10) groups were treated with 5% and 10% eucalyptol, respectively. Wound areas were measured on days 1, 4, 7, 11, 14, 18, and 21 days after wound creation. Wound tissues were collected on days 7 and 21. Histopathological, gene expression (TNFα, IL10, TGFβ1, VEGF), and biochemical (MDA, rGSH, GPx, CAT) analyses were performed on the wound tissues. TNFα gene expression levels were upregulated in Groups V and E5 (P<0.05). IL10 levels were upregulated in the V, E5, and E10 groups (P<0.05). TGFβ1 was upregulated in all groups compared with the control. Significant differences in rGSH, GPx, CAT, and MDA levels were found among all groups (P<0.05). Topical administration of 10% eucalyptol accelerates wound healing. With respect to epidermal thickness, 5% eucalyptol resulted in superior wound healing. Further studies should include different wound models, tissue analyses, and combinations of eucalyptol with other agents