Hatay Mustafa Kemal Üniversitesi Akademik Veri Yönetim Sistemi
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Finding balance in the digital world: The parallel mediating role of digital and mental well-being in the correlation between digital stress and internet addiction
No full textInternet addiction has emerged as a significant problem among university students. However, no study has been found in Turkey that examines the parallel mediating role of digital and mental well-being in the correlation between digital stress and internet addiction among university students. This study aims to examine the parallel mediating role of digital and mental well-being in the correlation between digital stress and internet addiction among university students. This descriptive study was conducted with 525 university students. The researcher collected data using “Internet Addiction Scale”, “Digital Stress Scale”, “Digital Well-Being Scale”, and “Mental Well-Being Scale”. It was found that 5.7% of university students were addicted to the internet, and 31.0% had a risky level of internet use. Students had moderate levels of digital stress, while their mental and digital well-being levels were above average. A significant correlation was determined between digital stress, digital well-being, mental well-being, and internet addiction (p < 0.001). All these predictor variables explained 50.2% of the variance in internet addiction (R² = 0.502). Digital well-being partially mediated the correlation between digital stress and internet addiction, while mental well-being did not significantly influence this correlation. These findings may assist mental health professionals in developing psychosocial interventions to encourage balanced internet use among university students
Göksel Baktagir’s Kanun Performance Techniques: The Instrumental Composition ‘Dalgalar’ as a Case Study
No full textThe Effect of Progressive Muscle Relaxation Exercises on Fatigue Severity and Sleep Quality Among Emergency Nurses: A Self-Controlled Quasi-Experimental Study.
No full textThe effect of dry-period heat stress on inflammatory, oxidative and metabolic alterations, and acquired immunity in dairy cows and offspring
No full textThis study aimed to investigate the effects of dry-period heat stress on metabolic and oxidative stress parameters, cytokine release, and T lymphocyte percentages in dairy cows and their offspring. Thirty-two Holstein cows were randomly assigned to heat stress (HS) and cooling (CL) groups. Blood samples were collected to harvest serum and isolate peripheral blood leukocytes, from cows at 21 – 28 days before the expected calving date and immediately after calving, and from their calves postnatally (before colostrum consumption and 24 ± 1 h after birth). Helper (Th1, Th2), regulatory T (Treg), and gamma/delta T (γδT) lymphocytes were enumerated by flow cytometry. Interferon gamma (IFN-γ), tumor necrosis factor- alpha (TNF-α), Interleukin-17A (IL-17A), IL-10, IL-6, IL-1β, retinol, alpha-tocopherol, lactoferrin, and immunoglobulin G (IgG) levels were measured using bovine-specific commercial enzyme-linked immunosorbent assay (ELISA) test kits. Nitric oxide, paraoxonase, total oxidant capacity, total antioxidant capacity, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase, malondialdehyde (MDA), albumin, total protein, cholesterol, bilirubin, and creatinine levels were measured using an auto-analyzer. Compared to the CL group, in the HS cows, serum retinoic acid, alpha-tocopherol (p < 0.05), ALP, catalase, GSH-Px and IL-1β levels (p < 0.01) were significantly lower, whereas IL-6, IFN-γ and IL-10 levels were higher (p < 0.01). The HS cows presented with higher Th1 lymphocyte percentages (p < 0.01), and lower γδT and Treg lymphocyte percentages (p < 0.01). Treg lymphocyte percentages showed no difference between the groups, but varied by day. Specifically, in both the HS and CL dams, Treg lymphocyte percentages were significantly lower at the calving time than on day 21 before the expected calving date (p = 0.021). Colostral IgG concentrations were lower (p < 0.05) in the HS group. In the offspring, there were no significant differences between the HS and CL groups for the T lymphocyte percentages before colostrum consumption and the serum IgG concentrations at 24 ± 1 h after birth. In conclusion, the study findings suggest that providing heat stress abatement to dry cows may modulate both Th1, Treg, and γδT lymphocyte functions, and the release of pro-inflammatory and anti-inflammatory cytokines. However, intrauterine heat stress did not affect lymphocyte percentages in offspring before colostrum consumption
Expression patterns of apoptosis- and ferroptosis-associated transcripts in uterine tissues of female dogs diagnosed with open- or closed-cervix pyometra
No full textIn dogs diagnosed with pyometra, cervical patency status may influence the predominance of apoptosis or ferroptosis, two mechanistically distinct forms of regulated cell death. We evaluated the expression of selected transcripts related to apoptotic and ferroptotic pathways in the uterine tissuee of female dogs diagnosed with open- or closed-cervix pyometra. Twenty-four bitches were classified as healthy (n = 8), open-cervix pyometra (n = 8), or closed-cervix pyometra (n = 8). Uterine tissue samples from each dog were collected for the quantification of apoptotic- (BAX, BCL-2, TP53, and CASP3) and ferroptosis-related transcripts (GPX4, SLC7A11, and TFRC) via qPCR. Immunohistochemical analysis was conducted using antibodies specific to the proteins encoded by BAX, BCL2, TP53, CASP3, GPX4, SLC7A11, and TFRC genes. Furthermore, protein-protein interaction (PPI) and enrichment analyses for the same genes were conducted. Data were fitted in Kruskal-Wallis tests to fit the effect of healthy, open-cervix pyometra, or closed-cervix pyometra on gene expression profile and immunohistochemistry staining parameters. Compared to control, the expression of BAX, SLC7A11, TFRC, GPX were upregulated, BCL2 was downregulated in closed-cervix pyometra. Mild and strong immunopositivity in BAX, BCL2, TP53, CASP3 antibodies was observed in closed pyometra cases. In closed-cervix pyometra, severe inflammation was observed in the endometrium, with immunopositivity for SLC7A11 and GPX4 highlighted within the cytoplasm of mononuclear inflammatory cells, primarily located in the endometrial stroma. PPI analysis revealed proteins encoded by target genes, such as FADD, FASLG, and GSDME, considering maximum of 20 interactions per protein, resulting network highlights significant roles of proteins in various biological pathways, including apoptosis, ferroptosis, inflammation, cellular immunity. Apoptosis and ferroptosis are regulated in pyometra related cervical patency status and these pathways, more active in closed-cervix pyometra. This is the first study to identify apoptosis and ferroptosis pathways in pyometra, providing new insights into its pathophysiology and emphasizing prognostic relevance of both pathways, particularly in closed-cervix cases
Retina pigment epitelinin konjenital hipertrofisinin bilateral multifokal tipik formu: Nadir bir vaka sunumu
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A National Multicenter Study on Initial Antiviral Treatment Preferences on Chronic Hepatitis B: Entecavir Versus Tenofovir Disoproxil Fumarate
No full textBackground/Aims: Selecting the initial antiviral regimen for chronic hepatitis B (CHB) requires balancing patients' comorbidities and long-term safety. This study examines the differences in patient and disease-related factors that guide clinicians to prescribe either entecavir (ETV) or tenofovir disoproxil fumarate (TDF) as the initial treatment. Materials and Methods: The study included treatment-naïve CHB patients aged 18 or older who had been diagnosed for at least 1 year since 2010 and initiated on antiviral therapy. The data included variables such as age, gender, body mass index (BMI), comorbidities, liver disease activity, biopsy results, cirrhosis, hepatic steatosis, hepatitis B e-antigen status, hepatitis B virus DNA levels, triglycerides, cholesterol, renal function, and baseline bone mineral density (BMD), which were assessed by dual-energy x-ray absorptiometry (DEXA). Results: Among 2259 patients (61.6% male), 1270 patients (56.22%) received TDF, while 989 patients (43.78%) received ETV as first-line therapy. The TDF was more commonly prescribed to patients with a lower BMI (median 25.7 vs. 26.2, P = .001) and lower baseline creatinine (0.75 vs. 0.80 for ETV, P < .001). Clinicians preferred ETV among patients with an estimated glomerular filtration rate (eGFR) < 60 (n = 36), (P < .001). The BMD was evaluated in 365 patients (16.3%). The DEXA scans were performed for 116 patients (11.8%) in the ETV group and 249 patients (19.8%) in the TDF group (P < .001). Conclusions: This national multicenter study emphasizes that patient-related factors, including gender, age, baseline renal function, and liver disease severity, significantly influence the choice of first-line antiviral therapy for CHB, often outweighing disease-specific factors
Formulation and Characterization of Hydrogel Based on Pectin, Collagen, Alginate and Myrtus communis Essential Oil for Applications in Skin Regeneration
No full textThis paper proposes a potential solution to the current issue of developing advanced, biocompatible biomaterials with integrated therapeutic functionality, which would contribute to improving the treatment of skin defects. This study aimed to develop, characterize and evaluate hydrogels based on type I collagen, pectin, alginate and myrtle essential oil, in order to obtain biomaterials with potential in skin regeneration applications. Hydrogels incorporating alginate, pectin, type I collagen and Myrtus communis essential oil were prepared via a multistep procedure comprising homogenization, crosslinking and lyophilization. The obtained hydrogels were characterized by physicochemical and structural methods, such as FTIR spectroscopy, to identify interactions between components; micro-computed tomography, to evaluate internal morphology and porosity; antibacterial tests, for evaluating the ability of the hydrogel to prevent infections at the application site; and in vitro cellular tests, such as the XTT test or cytotoxicity tests, such as LDH, essential for evaluating the biocompatibility of the hydrogel. The highest viability value was recorded for sample J4 (99.53 ± 11.88%), indicating an exceptional compatibility with the cells used, almost identical to that of the untreated control. The samples showed encouraging results, supporting their potential for applications in wound treatment and skin regeneration