Hatay Mustafa Kemal Üniversitesi Akademik Veri Yönetim Sistemi
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Heat stress mitigation by zinc oxide nanoparticles in pepper and watermelon
No full textBackgroundHigh temperature limits growth in pepper (Capsicum annuum L.) and watermelon (Citrullus lanatus L.). We tested whether foliar zinc oxide nanoparticles (ZnO NPs; 100 mg L⁻¹) mitigate heat stress (35 °C) in a side-by-side, multi-genotype design spanning both species under identical conditions. By evaluating multiple genotypes of two species under matched regimes, we enable direct cross-species comparison; multivariate analyses (PCA, PLS-VIP) summarize trait importance.ResultsHeat significantly reduced SPAD, growth, and biomass (p < 0.05). ZnO NPs partly alleviated injury in a genotype-dependent manner: in pepper P2, SPAD rose by ~ 35% and dry weight by ~ 33% versus heat controls; in watermelon W1, shoot length increased from 21.4 to 30.0 cm and fresh weight ~ 3.3-fold. Conversely, W2 showed limited or negative responses, indicating Zn sensitivity at the tested dose. PCA separated heat from control groups and shifted several ZnO-treated profiles toward controls. PLS-VIP prioritized SPAD and biomass traits; given the small dataset and negative LOOCV R², multivariate outputs are interpreted as exploratory.ConclusionZnO NPs can mitigate heat injury, but effects are species- and genotype-dependent. These results motivate targeted, genotype-informed optimization before agronomic deployment.</p
Ceviz Kök Çeliklerinde Çelik Çapı, Çelik Boyu ve Aşı Başarısı Arasındaki İlişkiler. Bahçe, 89-92
No full textHastane Kaynaklı Staphylococcus aureus İzolatlarının Antibiyotik Direnç Profilleri: MRSA ve MSSA Suşlarının Fenotipik ve Moleküler Analizi
No full textStaphylococcus aureus, particularly methicillin-resistant strains (MRSA), remains a major cause of hospital-acquiredinfections worldwide. This study aimed to determine the prevalence of MRSA and methicillin-susceptible S. aureus (MSSA)among clinical isolates, evaluate their antimicrobial resistance profiles, and identify mecA positivity, inducibleMLSB (D-test), and hVISA phenotypes.A total of 161 S. aureus isolates obtained from various clinicalspecimens at Hatay Mustafa Kemal University Hospital between August 2023 and July 2024 were retrospectively analyzed.Identification was performed using MALDI-TOF and VITEK-2 systems. Antimicrobial susceptibility testing, inducibleMLSB detection (D-test), and hVISA screening were interpreted according to EUCAST guidelines. Methicillinresistance was confirmed by mecA gene detection via PCR.MRSA prevalence was 40%, beta-lactam resistance 63%, TMPSMX and macrolide resistance ranged from 25% to 30%, mecA positivity was 40%, inducible MLSB (D-test)was detected in 32%, and hVISA in 13% of isolates. Antibiotic resistance was higher among elderly patients and ICUadmissions, whereas MSSA predominated among outpatients.MRSA isolates demonstrated multidrug resistance, representinga significant challenge in hospital infection control and empirical therapy. This study provides updated local data on MRSAprevalence, mecA positivity, D-test, and hVISA phenotypes, contributing to evidence-based antibiotic stewardship andinfection control strategies. Continuous local surveillance, rational antibiotic use, and effective infection control strategiesare crucial to prevent the spread of resistant S. aureus strains.</p
CURRENT ANESTRUS MANAGEMENT IN EWES: THE RISING ROLE OF NON-STEROIDAL REPRODUCTIVE AGENTS
No full textSeasonal anestrusin ewes results from photoperiod-mediated suppression of hypothalamic GnRHpulsatility, leading to reduced LH secretion and cessation of ovulatoryactivity. To maintain flock fertility and sustain lamb production during thisperiod, estrus synchronization remains essential, and progestagen-basedprotocols are widely employed for this purpose. However, despite theirpractical effectiveness, these steroidal treatments present notable drawbacks,including residue concerns, welfare issues, and environmental impact,highlighting the need for alternative non-steroidal approaches. Recent advancesin reproductive neuroendocrinology have identified several non-steroidalcompounds capable of reactivating the reproductive axis by targeting centralregulatory pathways. Among these, kisspeptin analogs directly stimulateKISS1R-expressing neurons, inducing robust GnRH/LH secretion and reinitiatingcyclic ovarian activity. Dopamine antagonists facilitate reproductiveactivation by suppressing the heightened dopaminergic inhibition originatingfrom A15 neurons, thereby indirectly enhancing GnRH pulsatility and follicularprogression. Aromatase inhibitors, on the other hand, transiently suppressestradiol synthesis, thereby reducing the inhibitory feedback exerted on thehypothalamic GnRH neurons and facilitating increased GnRH release. Collectively,evidence indicates that these non-steroidal strategies target the majorneuroendocrine bottlenecks underlying seasonal anestrus through kisspeptin,dopaminergic, and estrogen-feedback modulation. Their short-acting profilesreduced welfare concerns, and lack of steroid residues position them aspromising next-generation tools for estrus induction and synchronization inanestrous ewes. This presentation will summarize their mechanisms of action,current efficacy data, and potential integration into reproductive managementprograms.</p
Topical delivery of Niaouli essential oil nanoemulsion via Chitosan:Polyvinyl alcohol patches: A promising antimicrobial strategy for potential biomedical applications
No full textNiaouli essential oil (NEO), selected as a bioactive compound, is a volatile oil known for its antiviral, antifungal, antibacterial, and antioxidant activities. To overcome the limitations associated with direct use of NEO, nanoemulsion formulations were developed, aiming for stability, long-term release, and controlled use. In this study, NEO nanoemulsions (NEO-NEs) were prepared, incorporated into a polymeric matrix, and evaluated for their potential use as antimicrobial patches. Three different oil-in-water emulsion formulations were produced, and the droplet size analyses were performed. Thin polymeric films were produced as carrier matrices for the optimal NEO-NEs formulation. Polymer matrices based on chitosan (CS) and polyvinyl alcohol (PVA) were physicochemically characterized in the presence of different volumes of NEO-NEs (10, 20, and 30 μL). The sample containing 20 μL of NEO-NEs exhibited a homogeneous morphology and achieved a swelling ratio of approximately 300 times its initial weight without compromising structural stability. Both direct and indirect cytotoxicity tests demonstrated that the NEO-NEs additive had no adverse effect on the biocompatibility. GC–MS analysis identified the main components of NEO, revealing a rich terpenoid composition that exhibited time-dependent antioxidant activity. Release studies showed a controlled, stable, and sustained release profile over 48 h. Microbiological evaluations showed high antifungal activity, particularly against Candida albicans . Overall, the findings of this study highlight the significant potential of NEO-incorporated polymeric adhesive patches for the prevention of fungal infections
Does economic freedom alleviate youth disengagement? An empirical analysis of NEET in the European Union
No full textLessons learned from the 2023 Türkiye twin earthquakes: how radiology facilities can respond to disasters
No full textOn 6 February 2023, back-to-back earthquakes (Mw 7.7 and 7.6) in southeastern Türkiye produced a prolonged mass-casualty incident, placing heavy demands on radiology services nationwide. Operational and clinical lessons were derived from frontline experience to guide emergency imaging under disaster conditions. Surge rostering and rapid staff redistribution were implemented; point-of-care ultrasound was employed for damage-control triage; and “CT-first” pathways were adopted for polytrauma. Workflow continuity during PACS/network outages was maintained with paper logs, downtime order sets, and standardized critical findings phrasing. Disaster teleradiology was activated through streamlined credentialing and ID-agnostic reporting, enabling rapid capacity expansion and support for hospitals beyond the epicentral region. Dominant injury patterns observed were crush injury with acute compartment syndrome; traumatic brain injury; chest trauma with sequential rib fractures, pulmonary contusion and pneumothorax; lumbar-predominant spinal fractures; and pelvic and long-bone injuries. Imaging correlates of rhabdomyolysis and non-lethal pneumomediastinum compatible with the Macklin effect are summarized. Protocol adaptations that preserved throughput and safety included abbreviated, low-dose trauma CT; cautious contrast use in renally vulnerable patients; and corridor-based scanner prioritisation during overflow. On the basis of these observations, a radiology preparedness bundle is presented: redundant power and IT failover; predefined modality-prioritisation matrices; caches of portable US/X-ray for secondary triage; streamlined trauma CT checklists; templated reports that foreground immediate actions; and interoperable teleradiology hooks that can be switched on rapidly. These measures are transferable to earthquakes and other mass-casualty events, sustaining diagnostic capacity, communication, and team alignment under extreme constraints
Urtica dioica L. attenuates bisphenol A-induced hepatotoxicity in rats by suppressing apoptosis and inflammation
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