Texas Journal of Medical Science
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Clinical Pharmacological Approach To The Use Of Antibacterial Therapy In Older People
No full textThe clinical pharmacological approach to antibacterial therapy in older people is crucial for ensuring effective treatment while minimizing adverse effects and resistance development. This article explores age-related physiological changes that influence drug pharmacokinetics and pharmacodynamics, including altered absorption, distribution, metabolism, and excretion. The selection of appropriate antibacterial agents, dose adjustments, drug interactions, and the risks of polypharmacy in elderly patients are analyzed. Additionally, strategies for optimizing therapy to reduce antibiotic resistance and improve patient outcomes are discussed, along with recent advancements in geriatric antimicrobial stewardshi
Diagnostics And Therapy Of Eye Allergic Diseases.
No full textThis paper represents literature review devoted to most actual ussues of diagnostics and therapy of eye allergic diseases. Information about modern methods of diagnostics of allergic conjunctivitis that used in clinical practice was systemized. Data from clinical tests on different drug groups and their effectiveness was delivered. Also there was performed comparative analysis of therapy plans that prescribed by different author
To prevent complications after surgery for stages 1-2 of cervical cancer
No full textCervical cancer is among the most common malignancies affecting women worldwide, with surgery serving as the cornerstone of treatment for early stages (I–II). Despite advances in surgical techniques and perioperative management, post-surgical complications remain a significant challenge. These include infectious processes, thromboembolic events, lymphatic complications, urinary and sexual dysfunction, and psychological disturbances, which may negatively affect quality of life and long-term prognosis
Chemokines And Growth Factors As Key Mediators Of Immunoangiogenic Mechanisms In Uterine Fibroids (Review Paper)
No full textThis review systematizes current data on the role of chemokines (CXCL8, CXCL10, CCL2, CCL3, CCL4, CCL5) and growth factors (VEGF-A, TGF-β1/β2, EGF, FGF2) in the immuno-inflammatory and angiogenic mechanisms underlying the pathogenesis of uterine fibroids. It is shown that elevated levels of these mediators promote the activation of macrophages, T-lymphocytes, and endothelial cells, thereby enhancing angiogenesis and stromal fibrosis. The imbalance between pro-inflammatory and angiostatic cytokines forms a microenvironment that supports the growth and recurrence of fibroid nodules. The summarized data confirm the pivotal role of chemokines and growth factors as pathogenetic determinants and potential biomarkers of leiomyoma activity, opening new prospects for the development of targeted and immunotherapeutic strategies in gynecolog
The Effect Of Long-Term Use Of Hypnotic Drugs On Cognitive Functions
No full textThis article provides a comprehensive analysis of the impact of long-term use of hypnotic drugs (benzodiazepines, Z-drugs, and melatonergic agonists) on cognitive functions. The neurobiological mechanisms of hypnotic agents—particularly changes in GABA-A receptor subunits, reduced synaptic plasticity in the hippocampus, and impaired memory consolidation—are outlined based on scientific literature. Research findings indicate that prolonged benzodiazepine use may reduce cognitive performance by 25–40%, while Z-drugs may decrease it by approximately 10–18%. Both reversible and irreversible forms of cognitive decline, along with their association with age, dosage, and treatment duration, are discussed. The study also examines the dynamics of cognitive recovery after discontinuation of hypnotics and evaluates the role of melatonin agonists, nootropics, and antioxidants in improving cognitive outcomes. The findings highlight the need for cautious and short-term use of hypnotic medications in clinical practice and form evidence-based recommendations for enhancing safety in the treatment of sleep disorders
Laboratory Characteristics And Diagnostic Significance Of Antibiotic-Associated Diarrhea In Young Children
No full textTo determine the specific laboratory characteristics of AAD in early childhood and assess the diagnostic value of fecal calprotectin, C-reactive protein (CRP), and coprological parameters in differentiating disease forms
Diagnostic Criteria Of Henoch–Schönlein Purpura (Hemorrhagic Vasculitis) In Children
No full textHenoch–Schönlein purpura (IgA vasculitis) is the most common systemic vasculitis of childhood. Despite the availability of international diagnostic standards, clinical heterogeneity and atypical presentations continue to contribute to delayed or inaccurate diagnosis, increasing the risk of renal and gastrointestinal complications. The EULAR/PRINTO/PRES criteria remain the most widely adopted framework, but their practical effectiveness requires continuous evaluation in light of new clinical and immunopathological evidenc
Remote results of modern surgical approaches in the treatment of esophageal cancer
No full textEsophageal cancer remains one of the most aggressive forms of gastrointestinal malignancy, characterized by a high mortality rate and poor prognosis. Surgery, often combined with chemoradiation, remains the primary definitive treatment option. In recent years, considerable attention has been paid to the analysis of long-term outcomes, including overall and disease-free survival, quality of life, and the incidence of complications and tumor recurrence. This paper presents summarized clinical observational da ta characterizing the long-term effectiveness of surgical treatment. Key factors influencing survival are identified, including tumor morphology, degree of invasion, surgical radicality, resection margin status, and comorbidities. A comparative analysis of the outcomes of open and minimally invasive procedures is also conducted. The data obtained confirm the need for a comprehensive approach, multidisciplinary monitoring, and optimized postoperative patient care to improve five-year survival
Blood Enzymes At Various Values Of External Temperature And Insolation Level
No full textBlood enzymes are key biochemical components of the body, participating in many vital processes, including metabolism, regulation of many physiological functions and reactions to changes in external factors. One of the significant influencing factors is the impact of ambient temperature, as well as the level of insolation, that is, the amount of solar radiation reaching the body's surface. With changes in external temperature, blood enzymes exhibit different activity. The activation or inhibition of biochemical reaction chains can be caused by both the temperature sensitivity of the enzymes themselves and changes in the body's internal homeostasis. However, excessive heating can also lead to protein denaturation, which seriously limits enzyme functionality. Insolation, in turn, can influence enzyme synthesis and activity through mechanisms associated with ultraviolet radiatio
Clinical Pharmacology Of Immunocorrector Drugs
No full textThe concept, strategy and principles of immunocorrection and immunomodulatory therapy, pharmacological and immunobiological characteristics, mechanisms of action of immunomodulators of various natures, indications for their use are presente