MX-RDR Macromolecular Xtallography Raw Data Repository
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Structure of E.coli Class 2 L-asparaginase EcAIII, wild type (WT EcAIII)
No full textraw X-ray diffraction data</p
Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-8 (G206Y, R207Q, D210P, S211T)
No full textX-ray diffraction data</p
Crystal structure of aminotransferase Aro9 from C. Albicans with ligands
No full textAminotransferases catalyze reversibly the transamination reaction by a ping-pong bi-bi mechanism with pyridoxal 5'-phosphate (PLP) as a cofactor. Various aminotransferases acting on a range of substrates have been reported. Aromatic transaminases are able to catalyze the transamination reaction with both aromatic and acidic substrates. Two aminotransferases from C. albicans, Aro8p and Aro9p, have been identified recently, exhibiting different catalytic properties. To elucidate the multiple substrate recognition of the two enzymes we determined the crystal structures of an unliganded CaAro8p, a complex of CaAro8p with the PLP cofactor bound to a substrate, forming an external aldimine, CaAro9p with PLP in the form of internal aldimine, and CaAro9p with a mixture of ligands that have been interpreted as results of the enzymatic reaction. The crystal structures of both enzymes contains in the asymmetric unit a biologically relevant dimer of 55 kDa for CaAro8 and 59 kDa for CaAro9p protein subunits. The ability of the enzymes to process multiple substrates could be related to a feature of their architecture in which the active site resides on one subunit while the substrate-binding site is formed by a long loop extending from the other subunit of the dimeric molecule. The separation of the two functions to different chemical entities could facilitate the evolution of the substrate-binding part and allow it to be flexible without destabilizing the conservative catalytic mechanism.</p
Beta-lactoglobulin mutant FAF (I56F/L39A/M107F), unliganded form - raw diffraction data
No full textRaw diffraction data for Beta-lactoglobulin mutant FAF (I56F/L39A/M107F), unliganded form</p
MS644_2_k1_P2_4_1 - raw diffraction data: Crystals of synthetic supramolecular peptidic capsules based on the scaffold of calix[4] resorcinarene
No full textRaw diffraction data collected at P13 beamline, PetraIII EMBL Hamburg: crystals of synthetic supramolecular peptidic capsules based on the scaffold of calix[4]resorcinarene, sample MS644_2_k1_P2_4_1.</p
DNA/2'-O-methyl-RNA heteroduplex with overhangs
No full textDNA/2'-O-methyl-RNA heteroduplex with overhangs</p
Raw diffraction data, ins180-26S_D6_2_1. Co-crystals of insulin and resorcin[4] arene amino acid derivatives.
No full textCo-crystallization trial, sample ins180-26S_D6_2_1, Co-crystals of insulin and and resorcin[4] arene amino acid derivatives.</p
Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenosine, K+ and Cu2+ cations (crystal p9x4)
No full textRaw diffraction data, S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa with adenosine, K+ and Cu2+ cations (crystal p9x4)</p
6SEI Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease - raw diffraction data
No full textRaw diffraction data for 6SEI PDB entry entitled Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease.</p
Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenosine, K+ and Cd2+ cations (crystal p10x1_2)
No full textRaw diffraction data, S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa with adenosine, K+ and Cd2+ cations (crystal p10x1_2)</p