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    AKTIVITAS ANTIOKSIDAN SEDIAAN GEL MENGANDUNG EKSTRAK ETANOL DAN FRAKSI ETIL ASETAT DAUN Aquilaria microcarpa

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    Abstract. Herbal medicine in pharmaceutical therapy has widely studied and developed. However, Aquilaria microcarpa as one of plants existing in South Kalimantan, has not been studied for its benefit yet. Aquilaria microcarpa leaves extract has been proved could lowered mice blood sugar level, probably because of its flavonoid content. Flavonoid were known has antioxidant activity. Extract and fraction were difficult to apply, therefore it is needed to make them to a dosage form. This study was aimed to determine antioxidant activity of gel consisting ethanolic extract and ethyl acetate fraction of Aquilaria microcarpa leaves. Antioxidant activity were evaluated for IC50 value using DPPH (2,2-diphenyl-1-picrylhydrazyle) methode. Extract were obtained from ultrasonicatedmaceration in ethanol 96% solvent. Extract were processed further in nhexane and ethyl acetate, where latter fraction were used. Each extract and fraction then made to gel, using HPMC as gel-base (1-2%). Result showed IC50 value for gel extract were 26,39 – 28,94 ppm and for gel fraction were 22,22 – 23,05 ppm. Both has highly active antioxidant activity. Keywords: Aquilaria microcarpa leaves, ethanolic extract, ethyl acetate fraction, antioxidant activity, ge

    Risk of Nephrotic Syndrome for Non-Steroidal Anti-Inflammatory Drug Users

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    Background and objectivesNonsteroidal anti-inflammatory drugs (NSAIDs) have been associatedwith AKI. Their association with nephrotic syndrome has not been systematically studied. This study aimed to assess the risk of nephrotic syndrome associated with NSAID use. Design, setting, participants, & measurements A matched case-control study was performed in the UK primary care database. Cases were patients with a first diagnosis of nephrotic syndrome and controls were those without nephrotic syndrome. NSAID exposure (grouped either based on cyclooxygenase enzyme selectivity and chemical groups) was classified as either current (use at the nephrotic syndrome diagnosis date and corresponding date in the control group), recent, or past use. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Results We included 2620 cases and 10,454 controls. Compared with non-use, current use of 15–28 days and .28 days of conventional NSAIDs was associated with a higher relative risk of nephrotic syndrome: adjusted OR, 1.34; 95% CI, 1.06 to 1.70, and OR, 1.42; 95% CI, 0.79 to 2.55, respectively. Also, recent use (discontinuation 1–2 months before nephrotic syndrome diagnosis date; OR, 1.55; 95% CI, 1.11 to 2.15) and past use (discontinuation 2months-2 years; OR, 1.24; 95% CI, 1.07 to 1.43), but not current use of ,15 days (OR, 0.78; 95% CI, 0.46 to 1.31) nor past use (discontinuation .2 years; OR, 0.96; 95% CI, 0.85 to 1.09) were associated with a higher relative risk of nephrotic syndrome as well as past use of selective COX-2 inhibitors (discontinuation 2–24 months; OR, 1.24; 95% CI, 0.98 to 1.58). Categorization based on chemical groups showed that acetic acid and propionic acid derivatives were associated with a higher risk of nephrotic syndrome. Conclusions The use of conventional NSAIDs was associated with a higher risk of nephrotic syndrome starting from at least 2 weeks of exposure, as well as for recent and past exposure up to 2 years before the diagnosis of nephrotic syndrome. This higher risk appeared mainly attributable to acetic acid and propionic acid derivative

    Cek Plagiasi : self efficacy, coping stres dan prestasi akademik mhs psikologi

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    Analisis Tingkat Kekritisan Lahan Pada DAS Batulicin Kabupaten Tanah Bumbu Kalimantan Selatan

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    Pengelolaan sumber daya alam yang tidak dilakukan secara bijaksana dan berencana dapat menimbulkan berbagai gangguan terhadap keseimbangan ekosistem Daerah Aliran Sungai (DAS) antara lain terjadinya erosi tanah dan sedimentasi yang menyebabkan lahan kritis, banjir dimusim hujan, kekeringan dimusim kemarau, pencemaran air sungai dan menurunnya produktifitas lahan pertanian. Penelitian ini bertujuan adalah untuk mengetahui tingkat kekritisan lahan pada DAS Batulicin, sedangkan metode yang digunakan dalam penentuan tingkat kekritisan lahan dengan men jumlahkan skor kondisi kemiringan lereng, erosi, liputan lahan dan manajemen di DAS Batulicin. Berikut ini disajikan proses penilaian tingkat kekritisan lahan. Berdasarkan hasil penelitian diperoleh bahwa kawasan lindung dalam hutan diperoleh hasil tidak kritis 42.522,4 Ha, potensial kritis 705.306,7 Ha, agak kritis 10.874,4 Ha, kritis 4.453,8 Ha, dan sangat kritis 657,4 Ha, kawasan lindung di luar hutan diperoleh hasil tidak kritis 49.363,5 Ha, potensial kritis 218.8536,6 Ha, agak kritis 35.154,7 Ha, kritis 21.009,8 Ha, dan sangat kritis 1.977,4 Ha, sedangkan kawasan budiaya usaha pertanian diperoleh hasil tidak kritis 3.774,0 Ha ,potensial kritis 679.636,8 Ha , agak kritis 26.018,5 Ha, kritis 6.583,4 Ha, dan sangat kritis 1.174,8 H

    Mesostructure characteristics of smoker teeth

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    This study aimed to investigate the mesostructure characteristis if smoker's teeth. Eight subject were divided into two group including non smoker group and smoker group. The mesostructure was analyzed by scanning electron microscope. mesostructure of smoker showed irregular formation and bigger hole. In conclusion, smoking activity disrupt the remodeling surface of teeth. Keylords: smoking; dental structuere; suraface remodeling

    STUDI KARAKTERISTIK RELASI PARAMETER SIFAT FISIK DAN KUAT TEKAN UNIAKSIAL PADA CONTOH BATULEMPUNG, ANDESIT, DAN BETON

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    Kuattekanuniaksialatauuniaxialcompressivestrength(UCS)dansifatfisikmenjadiparameterpenentuyangsangatpentingdalamberbagaikeperluanrekayasamekanikabatuan.Kuattekanuniaksialberbagaijenisbatuansangatbervariasi.Kuattekanuniaksialbatuanutuhdipengaruhiolehsifatfisiknya.Penelitianinibertujuanuntukmengetahuihubunganantarparametersifatfisikdanantaraparametersifatfisikdengankuattekanuniaksialcontohbatulempung,beton,danandesitsertamengukursumbanganpengaruhvariabelbebasterhadapvariabelterikat.Pengujiansifatfisikdankuattekanuniaksialdilakukanterhadapmasing-masing5contohbatubara,batulempung,gipsum,andesit,danbetonsebagaiperwakilanmaterialhomogen.Selanjutnyadianalisiskorelasiantarparametersifatfisikyangterdiriatasbobotisiasli,bobotisikering,bobotisijenuh,kadarair,derajatkejenuhan,porositas,danangkaporidankuattekanuniaksialnya.Analisisdatahasilpengujianmenunjukkanbahwabobotisiasli,kering,danjenuhberkorelasinegatifdenganporositas.Semakintinggiporositas,nilaibobotisisemakinkecil.Kadarairberkorelasilinierpositifdenganperbedaanbobotisiaslidanbobotisikering,berkorelasilinierpositifpuladenganperbedaanbobotisijenuhdanbobotisikering.Parametersifatfisikyangpalingmempengaruhikuattekanuniaksialadalahkadarair,terutamapadabatulempung(R20.78)danbeton(R20.63).Tetapipadaandesit,parametersifatfisikyangpalingmempengaruhiadalahporositas(R20.91).Kata-katakunci:andesit,batulempung,beton,kuattekanuniaksial,sifatfisi

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