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Mitochondrial Stress-Induced Carboxyl-Terminal Extensions: A Critical Link Between Ribosome Associated Quality Control and Mitochondrial Quality Control
No full textRibosome-associated quality control (RQC) plays a crucial role in cellular homeostasis by identifying and resolving stalled translation events. Increasing evidence suggests a link between RQC and mitophagy, the selective degradation of damaged mitochondria. In this study, we demonstrate that blocking msiCTE inhibits mitophagy, establishing it as a key regulatory factor in this process. We further show that mitochondrial stress recruits RQC factors, facilitating selective mitophagy through specific autophagy receptors. Additionally, our findings reveal that a certain length of artificial CAT-tails can trigger mitophagy and that modulating RQC factors directly impacts mitophagy flux. These insights deepen our understanding of how ribosome surveillance mechanisms influence mitochondrial quality control and cellular stress adaptation
Using Generative AI to Procedurally Populate Assets in an ASCII Level
No full textThis study focuses on how to make use of generative AI in game level development by procedurally populating assets at a code-based level in a video game. The researcher aims to enhance developers’ efficiency in aesthetic milestone by adapting a pipeline in which generative AI handles decoration process that has less impact on gameplay. Consequently, the researcher creates a pipeline outlining the best practices for conducting the pipeline using generative AI. The researcher constructed a game level in Left 4 Dead 2 to explore the effectiveness of this pipeline. Testers play the level and provided feedback regarding their experiences, especially on decoration quality. The researcher analyzed this data to confirm or deny whether the pipeline enhances efficiency and at the same time maintains the decoration quality of an average human-designed level
Ready or Not: How Congressional Dysfunction and \u3cem\u3eLoper Bright Enterprises v. Raimondo\u3c/em\u3e will Shift U.S. Regulation of Emerging Technologies to the Federal Bench
No full textThis Article is the first in legal academic literature to consider how the power shift generated by Congressional dysfunction and the Supreme Court’s decision in Loper Bright Enterprises v. Raimondo will affect emerging technology law. Power is moving toward the judicial branch of government— and away from the legislative and executive branches. As a result, federal courts will now take a leading role in the evolution of emerging technology law in the United States.
Unfortunately, the federal judiciary is not prepared for this new era. Drawing from the information processing theory, this Article explains why federal judges will be deciding complex and far-reaching cases without a deep understanding of the technologies underlying those cases. An overworked judiciary could create contradictory rulings, while the cost of compliance will increase and may lead to a wealth bias in favor of large technology companies. This situation will upset the delicate policy goal of protecting consumers while promoting innovation.
But the solutions to these problems also lie in the judicial branch. This Article proposes the creation of a specialized “Tech Court” that would increase uniformity and predictability, promote judicial efficiency, and prevent forum shopping. The Article also proposes specific initiatives for improved judicial education and the installation of technology advisers in judicial chambers. In the end, this Article is a call to action: The federal judiciary must get prepared to lead in the post-Chevron era
The FDA\u27s Crisis is Everyone\u27s Crisis
No full textOn April 1, 2025, the US Department of Health and Human Services (HHS) fired about 3500 US Food and Drug Administration (FDA) employees, nearly 20\% of agency staff. HHS also forced out career senior leaders at the FDA, including the director of the Center for Biologics Evaluation and Research, the director of the Center for Tobacco Products, and the chief medical officer, and has suggested a dramatic reorganization of the FDA into “five shared services offices,” potentially replacing the FDA’s centers. This followed the February 2025 firing of roughly 700 FDA employees, including staff responsible for overseeing food and device safety (before some were called back). And these changes at the FDA come amid a long list of controversial government-wide staffing directives from the Trump administration, including instructions to implement return-to-office policies, consult the US Department of Government Efficiency (DOGE) about career appointments, and hire no more than 1 employee for every 4 that depart