Bicocca Open Archive Research Data
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Data for "Labeled loans and human capital investments"
No full textCodes and database originated for the manuscript published in the DOI article: 10.1016/j.jdeveco.2023.10305
Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity
No full textChemotherapy-induced peripheral neurotoxicity is one of the most common dose-limiting toxicities of several widely used anticancer drugs such as platinum derivatives (cisplatin) and taxanes (paclitaxel). Several molecular mechanisms related to the onset of neurotoxicity have already been proposed, most of them having the sensory neurons of the dorsal root ganglia (DRG) and the peripheral nerve fibers as principal targets. In this study we explore chemotherapy-induced peripheral neurotoxicity beyond the neuronocentric view, investigating the changes induced by paclitaxel (PTX) and cisplatin (CDDP) on satellite glial cells (SGC) in the DRG and their crosstalk. Rats were chronically treated with PTX (10 mg/Kg, 1qwx4) or CDDP (2 mg/Kg 2qwx4) or respective vehicles. Morpho-functional analyses were performed to verify the features of drug-induced peripheral neurotoxicity. Qualitative and quantitative immunohistochemistry, 3D immunofluorescence, immunoblotting, and transmission electron microscopy analyses were also performed to detect alterations in SGCs and their interconnections. We demonstrated that PTX, but not CDDP, produces a strong activation of SGCs in the DRG, by altering their interconnections and their physical contact with sensory neurons. SGCs may act as principal actors in PTX-induced peripheral neurotoxicity, paving the way for the identification of new druggable targets for the treatment and prevention of chemotherapy-induced peripheral neurotoxicity
CrBr3
No full textElectron spin resonance data on a single Crystal of CrBr3 recorded as function of the temperature and crystal rotation.
Information about magnetic anisotropy, 2D dimensionality were exctracted from the analysis of the resonance field, resonance linewidth and ESR intensity
Degli Antoni, G. & Vittucci Marzetti, G. 2022 Estimating the effect on happiness through question randomization: An application to blood donation - Dataset
No full textData discussed and analyzed in the paper Degli Antoni, G. & Vittucci Marzetti, G. (2022), Estimating the effect on happiness through question randomization: An application to blood donation, Social Science & Medicine, DOI: 10.1016/j.socscimed.2022.11525
High glucose induces an activated state of partial epithelial-mesenchymal transition in human tubular cell cultures
No full textTubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this study, we investigated the phenotypic and molecular EMT-like changes and the alteration of inflammatory and fibrogenic secretome induced by HG in human primary tubular cell cultures. Taking advantage of this in vitro cell model composed of proximal and distal tubular cells, we showed that HG-treated tubular cells acquired a fibroblast-like morphology with cytoplasmic stress fibers, maintaining the expression of the epithelial markers specific of proximal and distal tubular cells. HG increased Snail1, miRNA210 and Vimentin mesenchymal markers, decreased N-cadherin expression and migration ability of primary tubular cells, while E-cadherin expression and focal adhesion distribution were not affected. Furthermore, HG treatment of tubular cells altered the inflammatory cytokine secretion creating a secretome able to enhance the proliferation and migration of fibroblasts. Our findings show that HG promotes an activated state of partial EMT in human tubular primary cells and induces a pro-inflammatory and pro-fibrogenic microenvironment, supporting the active role of tubular cells in diabetic nephropathy onset
Data related to article "Facemasks impair the recognition of facial expressions that stimulate empathy (sadness, fear and disgust): an ERP study"
No full textIn this study, ERPs were recorded in a group of 26 healthy male and female students engaged in recognizing 6 facial expressions of people wearing or not wearing surgical masks. Faces were preceded by the visual presentation of emotion prime words that were congruent or incongruent with the facial expression. The data of this collection are grand-average waveforms of Event-Related potentials (ERPs) recorded in healthy right-handed humans from 128 electrode sites at 512 Hz of sampling rate. The time epoch is 800 ms. ERP data were processed in two different ways: i) considering all EEG trials, or ii) only that not associated with an incorrect response. However, due to the largely uneven error rate across conditions (e.g., for masked faces or subtle emotions) ranging from 3.22 to 55.66%, the second method was considered unsound from the methodological point of view, and the more conservative and rigorous approach was preferred. Differences across conditions (masked vs. unmasked) were in fact larger when considering only correct responses. It should be noted that ERPs computed on the correct recognitions mostly contained signals reflecting the processing of easier to recognize stimuli (e.g. happy unmasked faces)
CrSBr_esr
No full textElectron spin resonance data on a single crystal of CrSBr as function of the temperature and applied field direction
Pictionary-based communication tool for assessing individual needs and motivational states in locked-in patients: P.A.I.N. set
No full textThis set of communication tools is indicated for understanding the needs of locked-in (LIS) patients unable to speak or communicate through verbal, sign, or body language, and is ideal for communicating through Brain Computer Interface (with the P300 paradigm, speller, machine learning, EEG/ERP classification, eye tracking). It comprises 60 validated, easily comprehensible, pictorial tables depicting adult persons in various contexts that affect their physiological or psychological state. Their motivational states are illustrated in a small cloud. The drawings are in color and representative of both sexes and various ethnicity.
THIS MATERIAL CAN BE FREELY USED FOR RESEARCH OR CLINICAL PURPOSES, PROVIDED THAT APPROPRIATE CREDIT IS GIVEN TO THE SOURCE.
Proverbio, A.M., Pischedda, F. (2022). Validation of a Pictionary-based communication tool for assessing individual needs and motivational states in locked-in patients (P.A.I.N. set).
Terms and conditions: This material cannot be used for commercial purposes. Therefore it cannot be transferred to technological devices of any type and be sold. This material cannot be placed in any internet web site nor can it be provided to profit making companies, or to the media (television, journals). To request the PAIN set for clinical use, or for non-profit academic research purposes, write to [email protected] do not accept requests directly from students, nor do we accept any requests from students on behalf of their advisor. Students should ask their faculty advisor to make the request
Superoxo complexes on SACs for OER
No full textThe present superoxo_complexes.tar.gz file contains the optimized structures of the end_on and side_on oxygen complexes on TM@4N-Gr at the PBE or PBE+U level of theory
IN2SIGHT_MAN_UNIMIB_WP{1,5,7}_Management_Plans_20220223
No full textThis folder contains documents related to the regulatory plan (folder: Regulatory plan, D.5.1), to the Risk managament plan (folder: Risk Management, D1.1) and to the data management plan (folder: data management plan, D7.1). Update from Version 3 is the addition of the Annex 1 to the DMP that contains the indications for the data storage of digital pathology data