Bicocca Open Archive Research Data
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Optical_detection__magnetic_field_polarity
No full textThe data reports experiments conducted with optcial and microwave assisted detection of magnetic field polarity for the determination of the oprational sensitivity and experimetnal parameters optimization
Replication_data_for_Bove_DiSalvatore_Elia_JCR_2024
No full textReplication data for the paper: Bove, V., Di Salvatore, J., & Elia, L. (2024). What it Takes to Return: UN Peacekeeping and the Safe Return of Displaced People. Journal of Conflict Resolution, 69(5), 898-924. https://doi.org/10.1177/0022002724126719
Microbiome Modulation Uncouples Efficacy and Toxicity Induced by Programmed Death-1/Programmed Death-Ligand1 Blockade in multiple myeloma - NMR-based metabolomics of culture media
No full textIntestinal microbiota and gut-born T helper-17 (Th17) lymphocytes may act as drivers of smoldering multiple myeloma (SMM) to MM evolution. We demonstrate here that administering the human commensal Prevotella melaninogenica to transgenic Vk*MYC mice affected by Early-MM, mimicking human SMM, significantly delayed evolution to full-blown MM. Mechanistically, P. melaninogenica increased the production of short-chain fatty acids (SCFAs), preventing skew of dendritic cells towards a pro-Th17 phenotype and accumulation of Th17 cells in the bone marrow of treated mice. P. melaninogenica or butyrate synergized with anti-PD-L1 antibodies by restraining Th17 cell expansion while unleashing immune checkpoint blockade (ICB)-induced effector CD8+ T cells. P. melaninogenica also attenuated IL-17-mediated skin lesions that mimicked ICB-induced immune-related adverse events. Thus, modulation of the gut microbiota or SCFAs administration with or without ICB might represent treatment options for patients affected by plasma cell dyscrasias and other hematologic or solid tumors where IL-17 acts as driving force.
The present dataset contains:
- 1H NMR spectra acquired on control and growth media for PM and PH;
- CMP and .exp files created for metabolite quantification in MestreNova software by SMA analysis
Multimodal comparison of cold atmospheric plasma sources for biomedical applications - Dataset
No full textDataset for the article Multimodal comparison of cold atmospheric plasma sources for biomedical application
Repo_pr-2025-00432j
No full textHere a section of a human papillary thyroid carcinoma, analysed with MALDI-MSI and H&E stained.
The dataset includes:
-H&E stained WSI (ptc_core_tma_q3.tif);
-ROIs (geojson); SCiLS exchange format ROIs (SEF.zip);
-imzML of the differnt ROIs (imzML.zip).
The ROIs were obtained using the workflow presented in "Improving the annotation for Spatial Proteomics: A computational approach to enhance molecular characterization of Thyroid Nodules" .
A detailed description and scripts can be found at https://github.com/Vsc0/msi-enhanced
Raw Mapping data
No full textRaw data acquired with a Bruker IRIS hyperspectral scanner.
Spectral reflectance data between 400 and 2500 nm.
X-ray fluorescence data
Subject personal evalutation of hand and fingers
No full textComplete individual evaluation in cm for hand and finger of sighted and blind participants
Contribute of cytokines and macrophages in Paclitaxel and Oxaliplatin rat models raw data
No full textData refer to the contribute of cytokines and macrophages in two chronic models of chemotherapy-induced peripheral neuropathy (CIPN) comparing paclitaxel (PTX)- and oxaliplatin (OHP)-induced CIPN in rats. Results consists in behavioural, morphological/ morphometrical and neurophysiological assessments, obtained with the administration of PTX 10 mg/kg once a week and OHP 5 mg/kg twice a week