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Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity. Graudenzi et al.
No full textSupplementary Files of the article "Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity" by Graudenzi et al
Cannabinoids: an effective treatment for chemotherapy-induced peripheral neurotoxicity?
No full textmaterials and methods as supplementary data to the review "Cannabinoids: an effective treatment for chemotherapy-induced peripheral neurotoxicity?
Boundary surfaces and Hydraulic parameters of a 3D large scale FEM numerical model in the Milan City area (northern Italy)
No full textIn this folder are stored the data used in the Data in Brief article "Hydro-stratigraphic datasets for the reconstruction of a large scale 3D FEM numerical model in the Milan metropolitan area (northern Italy)" (Previati A., et al., 2020).
1. "SHP" folder contains the side boundaries of the model (Model_Domain.shp), the top and bottom boundaries (Ground_Surface_Elevation.shp, Model_Bottom.shp), the limit surface (Phreatic_Aquifer_Bottom.shp) between the shallow phreatic and the lower semi-confined aquifers and the hydraulic head isolines as on 2016 (Hydraulic_head_Isolines.shp).
2. "3DFEM_Mesh_Parameters.txt" contains the location (X, Y, Z Coordinate system EPSG:3003) of the mesh nodes and the associated parameters (hydraulic conductivity and porosity) as well as the grain size class, the aquifer system and the depositional system (see the associated article for a detailed description)
Data for: PIIGS in the Euro Area. An Empirical DSGE Model.
No full texttime series of selected macroeconomic variables used as observables in our estimation exercise
Data for: Deep Ranking Analysis by Power Eigenvectors (DRAPE): a polypharmacology case study
No full textA dataset comprising 55 molecules described by seven criteria was used. The criteria are composed of binding activity values for each target expressed as half maximal activity concentration (AC50), based on the dose-response curves, thus the smaller the concentration, the more active the molecules
IVL-SYNTHSFM-v2: a dataset for the evaluation of 3D reconstruction pipelines
No full textThis dataset contains images of five 3D models that can be used to evaluate pipelines for 3D reconstruction from images. Each model is placed in a reference scene and is rendered under different lighting and camera conditions. For each of the five models, 8 scenes are created and for each scene 100 images are taken from different points of view
SMA libraries for metabolite identification and quantification in cocoa extracts
No full textMetabolite libraries built from NMR spectra for natural, lavado and commercial cocoa and for two extraction procedures (hydroalcoholic and Soxhlet), using the Simple Mixture Analysis (SMA) tool implemented in MestreNova 12.4 software
Seismotectonics at the transition between opposite-dipping slabs (western Alpine region) - DATASET
No full textSupporting Information for the article entitled " Seismotectonics at the transition between opposite-dipping slabs (western Alpine region)" written by E. Eva, M.G. Malusà and S. Solarino.
Contents of this file: Details on data processing; Distribution of P+S phase picks for the stations used in this study; Data selected for the comparison between LSQR and SVD performances; Vertical errors calculated using HypoDD with SVD; Focal mechanisms computed for this study; Dataset after HypoDD relocation
Data for: Frontal Aureole Deposit on Acheron Fossae ridge as evidence for landslide-generated tsunami on Mars
No full textThe .diam files are the creter diameters to be used with the software craterstats2
The olimpo_nocart.exe is the executable to calculate the water splash; input data are requested when running the code; the txt files should not be modified
The runup_water_acheron6_pss is a small fortran code to calculate the run-up and velocity of the water wave with the analytical formula provided in the tex
The immune landscape of uterine leiomyosarcomas
No full textPersonalized immune intervention to release and redirect the T cells against a tumor has shown substantial progress in aggressive tumors such as melanoma and lung cancer, despite the fact that predictors of sustained response are still unclear. Data on less common histotypes are scanty. Among soft tissue sarcomas, uterine leiomyosarcomas (ULMS) have a dire prognosis, yet therapeutic advances are needed in order to improve the actual treatment. Immune checkpoint inhibitor therapy has been applied to exceptionally few cases, of which the immune cell composition was not examined in detail. We analyzed in situ the inflammatory infiltrate of 21 untreated ULMS in high-dimensional, single cell phenotyping on routinely processed tissue, directed at the characterization of lymphoid cells and macrophages. T-lymphoid cells displayed a composite phenotype common to all tumors, suggestive of antigen-exposure; in about half of the cases containing sufficient lymphocytes, we found evidence of exhaustion and a CD8+ TCF7+ phenotype, this latter associated with T-cell reactivation. To the contrary, myelomonocytic cells had case-specific individual combinations of phenotypes and subsets. We identified five distinct monocyte-macrophage cell types: histiocytes, phagocytes, tumor-associated macrophages, inflammatory monocytes and myelomonocytic cells of undefined phenotype. Immunosuppressive molecules (TIM3, B7H3, VISTA, PD1, PDL1) were heterogeneously expressed in inflammatory and endothelial cells. The heterogeneity and phenotype of the monocyte-macrophage population may represents a challenge for which we provide an initial understanding