eKhSACIR інституційному репозитарії Харківської державної академії культури
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Nourrir une ville : des circuits d'approvisionnement au réseau social spatialisé
No full textNational audienc
Diversity of maize landraces from south-west of France: origin and morphological differentiation analyzes
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How to control the dissemination of antibiotic resistance in the environment? A systematic review
No full textNational audienceThe massive use of antibiotics in human and animal health led to the emergence of antibiotic resistant bacteria (ARB). Antibiotic residues, ARB, their genes (ARG) as well as mobile genetic elements (MGE) are chronically introduced in aquatic and terrestrial environments by the discharge of wastewaters and organic wastes, directly or after treatment. The dynamics of ARG/MGE in these environmental reservoirs contributes to the dissemination of antibiotic resistance to pathogenic bacteria. The French Ministry of Ecological and Inclusive Transition commissioned a systematic review of literature on effective solutions to control the contamination of environment by ARB and ARG. According to published protocol [1] and One-Health approach, three sub-questions were addressed in this review to assess the effectiveness of 1) antibiotic use restriction, 2) treatments of wastewaters and organic wastes and 3) environmental management to reduce the environmental contamination by antibiotic resistance. Articles were analyzed through systematic map, qualitative and quantitative syntheses. After screening 17,798 articles from eight publication databases, 931 articles were included in the systematic map. While knowledge gaps were obtained for the 1st and 3rd sub-questions, a metaanalysis was carried out in sub-question 2 to determine effects of organic waste treatments on antibiotic resistance (126 studies, meta-regressions). Composting significantly reduced the relative abundance of ARG/MGE (84% removal, 27 studies, p < 0.05). Efficacy of anaerobic digestion is lower than composting with more heterogeneity in reducing ARG/MGE. The systematic review results will allow to: i) identify knowledge gaps for research (e.g., indicators of antibiotic resistance) and ii) develop recommendations for stakeholders and policy makers
Effects of maternal au-np exposure by inhalation on foeto-placental development and placental function, in a rabbit model
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Événements cellulaires et régulations au cours de la morphogenèse foliaire chez Arabidopsis thaliana
No full textHow a shape arises from the coordinated behavior of cells is one of the most fascinating questions in developmental biology. Here we used the early stages of development of serrated leaves in Arabidopsis thaliana as a model to study the tight relation between cellular behaviour and morphogenesis. During Arabidopsis thaliana leaf development the fine control of cell proliferation and cell expansion sustains differential growth at the margin required for the formation of leaf outgrowth named teeth. In this model, differential growth is the result of interplay between auxin signaling and CUC transcription factors that are involved in the maintenance of boundary domain identity. To clarify the interconnected relations between patterns of CUC TFs and auxin responses as well as the cellular events behind serrations we used time-lapse experiments on vegetative primordia of lines expressing developmental and/or auxin response reporters. Our results revealed a tight and dynamic control of differential growth at the leaf margin and the critical involvement of CUC3 in the local repression of cell growth in combination with low auxin responses.Comprendre comment la coordination des cellules entre elles permet l’émergence d’une forme est une des questions les plus fascinantes en biologie du développement. Au cours de cette thèse, nous avons utilisé les premiers stades de développement des feuilles dentelées d'Arabidopsis thaliana comme modèle pour étudier la relation entre les évènements cellulaires et la morphogenèse. Pendant le développement des feuilles d'Arabidopsis thaliana, le contrôle fin de la prolifération et de l'expansion cellulaire permet la croissance différentielle au niveau de la marge foliaire, nécessaire à la formation des indentations. Dans ce modèle, la croissance différentielle est le résultat de l'interaction entre la signalisation de l’auxine et l’activité des facteurs de transcription CUP SHAPED COTYLEDONS impliqués dans le maintien de l'identité des domaines frontières. Pour affiner la compréhension des relations complexes entre les facteurs de transcriptions CUC, les réponses auxiniques et les événements cellulaires à l'origine des indentations foliaires, nous avons utilisé des expériences d’imagerie en temps réel sur des primordia foliaires de lignées exprimant des rapporteurs de développement et/ou de réponse auxinique. Nos résultats ont révélé un contrôle dynamique de la croissance différentielle à la marge des feuilles et l'implication critique de CUC3 dans la répression locale de la croissance cellulaire
Mono (2-ethyllexyl) phthalate induces transcriptomic and proteomic alterations in bovine oocytes.
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Monitoring of PAHs and pesticides in water and sediments from peri-urban ponds
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