Afyonkarahisar Health Sciences University Institutional Repository
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Can seasonal differences affective on frequency and mortality of pulmonary embolism?
No full textAims: Does a seasonal variation in the incidence of pulmonary embolism (PE) exist? The aim of our study is to assess seasonal variation in the incidence of PE and to determine whether there are any differences in mortality. Methods: Medical documentation of 402 patients diagnosed as acute PE in the five-year period were retrospectively analyzed. The study included patients aged 18 years and older with a diagnosis of PE confirmed by spiral thorax computed tomography. Results: The highest numbers of case were seen in spring (n=115, 28.6%). In terms of months, the greatest number of cases occurred in November (n=48, 11.9%) and April (n=47, 11.7%). Case distribution according to seasons and months were statistically significant (pAims: Does a seasonal variation in the incidence of pulmonary embolism (PE) exist? The aim of our study is to assess seasonal variation in the incidence of PE and to determine whether there are any differences in mortality. Methods: Medical documentation of 402 patients diagnosed as acute PE in the five-year period were retrospectively analyzed. The study included patients aged 18 years and older with a diagnosis of PE confirmed by spiral thorax computed tomography. Results: The highest numbers of case were seen in spring (n=115, 28.6%). In terms of months, the greatest number of cases occurred in November (n=48, 11.9%) and April (n=47, 11.7%). Case distribution according to seasons and months were statistically significant (
The Approach to Conspicuous Consumption from the Perspective of Islamic Economics
No full textGeçmişten günümüze “tüketim” farklı anlamlar kazanan bir kavramdır. İlk olarak insani fizyolojik ihtiyaçlar bağlamında başlayan temel tanımlamalar, bugün sosyolojik ve psikolojik ihtiyaçları daha çok anlatır olmuştur. İktisadi bir teori olan ve Thorstein Veblen tarafından ortaya atılan gösterişçi tüketim teorisi de, bu anlam genişlemesinin bir yansıması olarak ortaya çıkmıştır. “Gösterişçi Tüketim” ihtiyaçtan bağımsız olarak zengin ve onlara benzemeye çalışan sınıfların gösteriş amacıyla yapmış oldukları keyfi harcamaları ifade etmektedir. Bu tip harcamalar temel ihtiyaçları karşılamaktan ziyade bireysel arzuları, kimlik arayışını ve statü inşasını beslemektedir. Gösterişçi tüketim biçimi tüm dünyanın enflasyonla savaştığı mevcut dönemde daha bir belirgin hal almış, zengin ile fakir arasındaki açıklığı büyütmektedir. Gösterişe dayalı harcamalar, toplumda zengin ve yoksulun birbirine olan saygısı, muhabbeti, birbirlerini anlamalarına engel teşkil ederken, bireyleri kendi kaotik dünyasına hapsetmektedir. Bu gerçeklikten hareket eden çalışma, gösterişçi tüketimi ortaya çıkaran faktörlerin belirlenmesi, farkındalık üretilmesi ve İslam iktisadı açısından değerlendirilmesini amaçlamıştır. Çalışma, İslam iktisadı yaklaşımının geleneksel ekonomi ile ontolojik farklıklarının ortaya koyulması ve toplumsal sağduyuya katkı sağlaması yanında gösterişçi tüketimin tehlikelerinin anlaşılması açısından önem arz etmektedir. İncelemeler neticesinde İslam iktisadı anlayışa göre, gösterişçi tüketimin Kur’an-ı Kerim ve Hz. Muhammed’in Sünnetleri’ ışığında olumlu görülmeyip, özellikle riya, israf, mülkiyetin doğru kullanımı açılarından eleştirilmektedir. İslam’ın bu konuda koymuş olduğu ilkelere göre, gösterişçi tüketime karşı harcamalarda itidalli ve sefahetten uzak davranmanın insanın maddi ve manevi tatmini bakımında daha yerinde olduğu görülmektedir
Knowledge levels and attitudes of Turkish nursing students regarding medical device-related pressure injuries and factors influencing them: A cross-sectional study
No full textAim: The aim of this study was to determine nursing students' levels of knowledge and attitudes regarding medical device-related pressure injuries (MDRPIs), as well as the factors influencing these. Materials and methods: This descriptive and cross-sectional study was conducted with 581 nursing students between January and May 2024. Data were collected using the Student Information Form, the Medical Device Related Pressure Injury Knowledge Assessment Test (MDRPI-KAT), and the Medical Device Related Pressure Injury Attitude Questionnaire (MDRPI-AQ). Results: The nursing students had a mean score of 8.76 +/- 2.68 on the MDRPI-KAT, indicating an overall correct answer percentage of 54.7%. The mean total score on the MDRPI-AQ was 44.08 +/- 8.12. Furthermore, 75.0% of the nursing students (n = 436) achieved a positive attitude score (>40 points). According to the results of the structural equation model, the scores on the MDRPI-KAT among nursing students had a statistically significant effect on their scores on the MDRPI-AQ (beta = 0.585, p = 0.002). Conclusion: This study found that the nursing students exhibited insufficient knowledge about MDRPIs.Despite this, the nursing students demonstrated a positive attitude toward MDRPIs
Multi-Target Quinoxaline Derivatives for Alzheimer's Disease: Inhibitory Activities Against AChE and BACE-1 Enzymes
No full textNew choline esterase inhibitors and B-secretase inhibitors present promising treatment options for the treatment of Alzheimer's disease (AD). In this study, molecular docking was performed using our chemistry library to discover lead compounds. Molecular docking was employed to predict binding affinities, while molecular dynamics (MD) simulations provided insights into the stability of the ligand-enzyme interactions. To improve the activity, 12 new derivatives were designed and synthesized based on the lead compound obtained. The structures of the synthesized compounds were identified by 1H-NMR,13C-NMR, and HRMS techniques. Their activities on choline esterase enzymes and Beta-secretase 1 enzyme were elucidated through in vitro studies. Compound 4f had an IC50 = 0.026 +/- 0.001 mu. value against the acetylcholinesterase (AChE) enzyme and an IC50 = 0.125 +/- 0.005 mu. value against the BACE-1 enzyme. The excellent activity of compound 4f was supported by molecular docking and MD simulation studies.Anadolu University Scientific Research Project [2204S034, 2209S149]; Eskisehir, TurkeyThis study was supported by the Anadolu University Scientific Research Project (Project Numbers: 2204S034 and 2209S149), Eskisehir, Turkey. As the authors of this study, we thank Anadolu University Faculty of Pharmacy Central Research Laboratory (MERLAB), for their support and contributions
Is maintenance chemotherapy always necessary in gestational trophoblastic neoplasia? A retrospective cohort analysis
No full textObjectives: Gestational trophoblastic neoplasia (GTN) is a rare but highly curable group of gestational tumors. Current risk stratification relies on the International Federation of Gynecology and Obstetrics (FIGO) staging and WHO scoring systems, yet both have shown limited accuracy in predicting relapse or chemoresistance. The necessity of routine maintenance chemotherapy following remission - particularly in low-risk patients - remains controversial. Methods: We conducted a retrospective cohort study of 25 patients with GTN treated between 2006 and 2022. Demographic, clinical, and treatment-related data were analyzed. Outcomes of interest included methotrexate (MTX) resistance, relapse, and the use of maintenance chemotherapy. Follow-up duration and disease outcomes were assessed descriptively. Results: The median age at diagnosis was 28 years. Most patients (76%) had FIGO stage I disease; 44% were classified as high-risk. MTX resistance occurred in two patients (8%), both low-risk. Only one relapse was observed, occurring five years after remission. Maintenance chemotherapy was given to 64% of patients. Notably, none of the eight patients who did not receive maintenance therapy - including four high-risk cases - experienced relapse. No clear difference in outcomes was observed between stage I and stage III patients. Conclusions: In this real-world cohort with long-term follow-up, maintenance chemotherapy did not appear necessary to prevent recurrence, even in select high-risk patients. Additionally, the FIGO/WHO systems showed limited prognostic discrimination. These findings support the need for individualized, response-adapted management strategies and underscore the limitations of current risk models in GTN
The Relationship Between Impulsivity, Anxiety and Internet Addiction in Adolescents with Autism Spectrum Disorder: A Moderated Mediation Model
No full textWe aimed to examine the relationship between impulsivity and Internet Addiction (IA) evaluating autism symptoms, inattention, hyperactivity, loneliness, anxiety, and depression in adolescents with Autism Spectrum Disorders (ASD). We also investigated whether symptoms of autism, anxiety or depression moderate and/or mediate the relationship between impulsivity and study variables in predicting the severity of IA. Participants (n = 46 adolescents with ASD, ages 12-18) were assessed through Autism Spectrum Screening Questionnaire (ASSQ), Revised Child Anxiety and Depression Scales, Turgay DSM-IV-Based Disruptive Behavioral Disorders Screening and Rating Scale, The Barratt Impulsiveness Scale-Brief, Young Internet Addiction Scale, and UCLA Loneliness Scale. For all the mediation models, total effect of impulsivity on IA was statistically significant (b = 0.329, p < 0.05). The mediator effects of Separation Anxiety Disorder (SpAD) (b = 0.495, CI = 0.039-1.256), and Generalized Anxiety Disorder (GAD) (b = 0.786, CI = 0.113-1.811) were statistically significant on the path between impulsivity and IA. The direct effect of impulsivity on SpAD was moderated by ASSQ (b = 0.041, p < 0.05). SpAD and GAD mediates the relationship between impulsivity and IA. The higher the autism level, the more likely the individual with ASD is to become an internet addict, strengthening higher relationship between impulsivity, SpAD, and GAD
THE IMPACT OF ARTIFICIAL INTELLIGENCE ON EMPLOYMENT: A PANEL DATA ANALYSIS FOR SELECTED COUNTRIES*
No full textVarious artificial intelligence technologies such as robotics, machine learning, natural language processing, deep learning, and automation have developed rapidly in recent years and their use has become increasingly widespread in all areas that can affect the economy. These technologies have the capacity to optimize production processes, enhance efficiency levels, and play a decisive role in shaping trade and economic growth. Furthermore, they possess significant potential to exert notable impacts on employment and income inequality. The rise of artificial intelligence has sparked widespread debate, particularly regarding its potential impact on employment dynamics. The study analyzes the effect of artificial intelligence on employment in 29 countries from 2017 to 2021 using the SystemGMM estimator. The results showed a statistically significant positive effect of artificial intelligence on employment. The analysis also considers the potential impact of labor productivity on employment in relation to artificial intelligence technologies by including an interaction term in the same model. The estimation results show that while the impact of artificial intelligence and labor productivity on employment is positive when considered individually, the interaction term diminishes this positive effect
Chronobiology and Chronotherapy-Related Effects in Non-Traumatic Pain Presentations in the Emergency Department: A Retrospective Study
No full textObjectives: Pain is one of the most frequent reasons for emergency department (ED) admissions, yet the chronobiological patterns of pain-related presentations remain insufficiently explored. This study aimed to retrospectively analyze the temporal and seasonal characteristics of non-traumatic pain-related ED visits, with a focus on daily and seasonal variations influenced by circadian rhythms. Methods: This retrospective, descriptive, cross-sectional study included adult patients (?18 years) who presented to the Afyonkarahisar Health Sciences University Adult ED with non-traumatic pain between January 1, 2023, and December 31, 2023. Cases were identified based on ICD-10 codes for headache (R51, G43, G44), chest pain (R07.1–R07.4), abdominal pain (R10.0–R10.4), and musculoskeletal pain (M54, M79, M25). Demographic data, admission times, diagnostic procedures, treatment initiation, and hospitalization rates were analyzed. Statistical analyses utilized appropriate parametric and non-parametric tests, with significance set at P<0.05. Results: A total of 4524 patients were included (53.9% female; mean age 47.3±21.4 years). Chest pain was the most frequent diagnosis (40%), followed by headache (35.6%), musculoskeletal pain (19.6%), and abdominal pain (4.8%). ED visits peaked in the evening (mode: 21:09) and were least frequent after midnight. Headache admissions were significantly higher in autumn (30.7%), while chest pain was most common in winter (32%). Women more frequently presented with headache and abdominal pain, while men predominantly reported chest and musculoskeletal pain. Conclusions: Non-traumatic pain-related ED visits appeared to follow certain chronobiological patterns with observable sex-related differences. These preliminary findings may contribute to understanding temporal trends in pain-related ED utilization and could serve as a basis for future studies exploring the potential role of chronotherapy in pain management. Validation through larger, multicenter, and prospective studies is needed to strengthen and generalize these findings
Presence of intravaginal foreign bodies in children evaluated for forensic medicine examination: Two case reports
No full textBackground: Child sexual abuse can present with a wide range of clinical findings, from severe anogenital injuries to the complete absence of symptoms. Intravaginal foreign bodies may also be observed as potential indicators of abuse. However, they often lead to delayed diagnosis due to their nonspecific clinical presentation. These cases should be thoroughly evaluated from both forensic and medicolegal perspectives, particularly in relation to possible sexual abuse and potential malpractice implications. Case Presentation: We report two cases of girls aged 4 and 11 years who presented with intravaginal foreign bodies. A cylindrical battery was removed from the 4-year-old child. The use of X-ray for diagnosis led to delays in establishing the correct diagnosis. The 11-year-old girl had been receiving antibiotics for three months due to persistent vaginal discharge. At the end of this period, a hair clip was removed from the vagina. In both cases, forensic medical and psychiatric evaluations revealed no evidence of sexual abuse. However, the diagnostic delays in both cases also gave rise to allegations of medical malpractice. Conclusion: Intravaginal foreign bodies should be considered in children with persistent vaginal discharge or bleeding. While ultrasonography is useful for initial evaluation, vaginoscopy is the gold standard for diagnosis. Possible sexual abuse must be assessed, and forensic examination should follow legal reporting. Diagnostic delays may result in malpractice claims
Turkish nurses' knowledge, attitudes and practices in the management of incontinence associated dermatitis: A descriptive and cross-sectional study
No full textObjective: This study aimed to determine nurses' current knowledge, attitudes, and practices in adult intensive care units and palliative care clinics regarding incontinence-associated dermatitis (IAD). Materials and methods: This descriptive cross-sectional study was conducted with 355 nurses in adult intensive care and palliative services at two hospitals. Data were collected between 5.03.2022 and 15.06.2022 using the Nurse Demographic Form and the Knowledge, Attitude and Practice of Nurses in Managing Incontinence- Associated Dermatitis Questionnaire. Results: The nurses' mean scores for Knowledge of IAD Etiology and Diagnosis were 19.11 (SD 3.29), mean scores for Knowledge of IAD Risk Factors were 23.82 (SD 4.27), mean scores for Attitude Toward IAD Prevention were 10.1 (SD 2.49), and mean scores for Practices for IAD Prevention were 23.71 (SD 3.97). It was found that nurses who used a risk assessment tool to diagnose IAD (p = 0.001), had a procedure or protocol (p = 0.001), and received training on IAD (p < 0.001) had significantly higher Attitude Towards Prevention of IAD scores. There was a positive correlation between the number of patients with IAD cared for by the nurses participating in the study and the scores of Practices to Prevent IADand Knowledge of IAD Risk Factors, Knowledge of IAD Etiology and Diagnosisand Attitude Towards Preventing IAD(p < 0.001). Conclusion: This study found that intensive care and palliative care nurses' knowledge, attitudes, and practices regarding IAD were insufficient. Considering that IAD is encountered more frequently in these units, it is essential to provide continuous and practical training to nurses about IAD, use risk assessment tools to prevent and treat IAD, determine protocols, establish clinical guidelines, and implement and standardize them