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Adsorptive treatment of phosphogypsum leachate by carbonaceous materials: a comparative study on performance evaluation
No full textExperimental, density functional theory and molecular docking studies about the interaction between 6-MP and DNA: A biosensor study
No full textIn the paper presents a new DNA biosensor including 6-Mercaptopurine (6-MP), a well-known anticancer drug. Interactions with single-stranded and double-stranded calf thymus DNA (ct ds DNA and ct ss DNA) of the mentioned drugs were checked via experimental and theoretical tools. The experimental part of the article includes the voltammetric analyses made to see the interaction between 6-MP and DNA. Impedance Spectroscopy (EIS) measurements were performed to evaluate changes in charge transfer resistance (Rct) due to interactions on the PGE surface. The limit of detection (LOD) was determined as 2.43 µg/mL and 1.13 µg/mL for ct -dsDNA and ct -ssDNA interaction, respectively. In the experiments, a low-cost electrode frequently used in electrochemical analysis, was preferred the pencil graphite electrode (PGE) was preferred. In the theoretical section, the chemical reactivity of 6-MP was highlighted in the light of Conceptual Density Functional Theory (CDFT) based reactivity descriptors and electronic structure principles. The nature of DNA-drug interaction was highlighted through Molecular Docking analysis and obtained docking results supported the experimental observations. Our study shows the interaction of 6-MP with DNA biosensors. It is an original study as it is being studied for the first time. Therefore, the results obtained will guide researchers in future studies on biosensors
Petrol Fiyatlarıyla Petrol Fiyat Belirsizliği Arasındaki İlişki: Frekans Alanda Nedensellik Testinden Kanıtlar
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Retrospective Analysis of Epistaxis Cases: The Impact of Comorbidity and Recurrence on Treatment Approaches
No full textABSTRACTObjective: This study aimed to evaluate the etiology and treatment approaches of patients who presented to our clinic with nosebleeds, in accordance with the current literature.Material and Methods: Between January 2018 and March 2023, patients diagnosed with epistaxis who either presented to the otorhinolaryngology outpatient clinic of a tertiary university hospital or were referred from the emergency department, and whose data were accessible through the hospital information system, were retrospectively analyzed.Results: Among 2,169 patients diagnosed with epistaxis, 658 patients aged 0–95 years who met the inclusion criteria were included in the study. The mean age was 38.4 years, and 54% were male. The highest number of admissions occurred in February. Among patients with available recurrence data, recurrent epistaxis was observed in 28.1% of cases, while a single episode occurred in 8.7%. Recurrence information was unavailable for the remaining patients. Single episodes were more frequent among females. Most patients were treated on an outpatient basis (78.9%) and received only medical therapy (90.4%). A history of surgery was present in 3.3% of cases, the majority following septorhinoplasty. Hospitalization was required in 2.6% of cases, most of whom had comorbid conditions. Recurrence rates were also higher among patients with comorbidities.Conclusion: Epistaxis is a common otorhinolaryngologic emergency that can generally be managed effectively with outpatient medical treatment. However, recurrence and hospitalization rates are higher in elderly patients and those with comorbidities. A thorough assessment of patients’ medical history and accompanying conditions is crucial for selecting the most appropriate treatment approach.Keywords: Epistaxis; Cauterization; Surgery; Comorbidity; Recurrence</p
