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TÜKETİCİ DAVRANIŞLARININ DİJİTAL VE MOBİL ÖDEMELERBAĞLAMINDA İNCELENMESİ: WOS TABANLI BİBLİYOMETRİK BİR ANALİZ
No full textNovel Schiff Bases: Synthesis, Characterization, Bioactivity, Cytotoxicity, and Computational Evaluations
No full textHypopharyngeal cancer is rare subtype of head and neck cancers with relatively poor prognosis. Current therapeutic modalities lack the potential to provide patients with better clinical outcome and quality of life. This study was conducted on the synthesis of 2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl-4-(2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl)-4-oxobutanoates (3) using biologically important 1,2,4-triazole. The condensation of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 4-formyl-2-methoxyphenyl-4-(4-formyl-2-methoxyphenyl)-4-oxobutanoate yielded the biologically active 2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl-4-(2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl)-4-oxobutanoates (3). The compounds obtained were analyzed via FT-IR,1H-/13C-NMR spectrometers, elemental analysis, and HRMS spectroscopic techniques. Furthermore, we aimed at investigating the potential of compounds 3a-g against FaDu hypopharyngeal cancer cells. We demonstrated that compounds 3c, 3e, and 3 g had relatively lower IC50 values compared to the remaining tested compounds and more importantly their IC50 values were comparable to 5-FU, which suggests them as important therapeutic agent candidates. These newly synthesized compounds were assessed for their inhibitory activities toward two human carbonic anhydrase isoforms I and II (hCA I and II). Then, molecular docking calculations were made to compare the biological activities of studied molecules against cancer proteins. Compound 3c has a docking score of −7.15 against squamous cell carcinoma protein with ID: 2DO4 and −5.49 docking score against squamous cell carcinoma protein with ID:5PJZ. ADME/T analysis was performed to examine the drug properties of studied molecules
Experimental study on the thermal conductivity of a water-based ternary hybrid nanofluid incorporating MWCNTs-COOH-Fe3O4-rGO
No full textThis study explores the thermal conductivity characteristics of ternary nanofluids composed of water-based Fe3O4-decorated carboxylated multi-walled carbon nanotubes (MWCNT-COOH), reduced graphene oxide (rGO), and Fe3O4-CNT-COOH/rGO nanocomposites. The investigation focuses on the influence of temperature and nanocomposite concentration. Ultrasonic probes were employed to ensure the stability of the nanofluid, and its structural properties were analyzed using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). Thermal conductivity measurements were conducted using a KD-2 Pro thermal analyzer across a temperature range of 25-60 °C and a nanocomposite mass fraction range of 0.025-0.1%. Results demonstrated that the thermal conductivity ratio increased with higher solid volume fractions and elevated temperatures. Notably, the impact of temperature became more significant at higher nanocomposite concentrations. The findings also revealed a maximum thermal conductivity enhancement of approximately 50%, achieved at a nanocomposite fraction of 0.1% and a temperature of 60 °C.</p
Semiprime Ideal of Rings with Symmetric Bi-Derivations
No full textLet Ω be a ring with ℘ a semiprime ideal of Ω, I an ideal of Ω, Δ ∶ Ω × Ω → Ω a symmetric bi-derivation and δ be the trace of Δ. In the present paper, we shall prove that δ is a ℘-commuting map on I if any one of the following holds: i. δ(σ) ○ κ ∈ ℘, ii. δ([σ, κ]) ± [δ(σ), κ] ∈ ℘, iii. δ(σ○κ)±(δ(σ)○κ) ∈ ℘, iv. δ([σ, κ])±δ(σ)○κ ∈ ℘, v. δ(σ○κ)±[δ(σ), κ] ∈ ℘, vi. δ(σ)○κ±[δ(κ), σ] ∈ ℘, vii. δ([σ, κ]) ± δ(σ) ○ κ − [δ(κ), σ] ∈ ℘, viii. δ([σ, κ]) ± [δ(σ), κ] + [δ(κ), σ] ∈ ℘, ix. Δ(σ, κκ3) ±Δ(σ, κ)κ3 ∈ ℘, x. Δ(δ(σ), σ) ∈ ℘, xi. δ(δ(σ)) = g(σ), xii. δ(σ)κ ± σg(κ) ∈ ℘, xiii. [δ(σ), κ] ± [g(κ), σ] ∈ ℘, xiv. δ(σ) ○ κ ± (σ ○ g(κ)) ∈ ℘, xv. [δ(σ), κ] ± (σ ○ g(κ)) ∈ ℘, xvi. δ(σ) ○ κ ± [g(κ), σ] ∈ ℘ for all σ, κ ∈ I where G ∶ ℵ × ℵ → ℵ is a symmetric bi-derivation such that g is the trace of G
Investigation of the effect of intravitreal bevacizumab treatment on left heart function using speckle tracking echocardiography Investigação do efeito do tratamento intravítreo com bevacizumabe na função cardíaca esquerda por ecocardiografia com speckle tracking
No full textIntroduction and objectives: Vascular endothelial growth factor (VEGF) inhibitors are widely used in oncology and ophthalmology. Although these agents have been shown to increase the risk of cardiovascular events in systemic use, the effect of local applications is unclear. In our study, we aimed to investigate the effects of anti-VEGF agents on left heart functions after intravitreal injection using speckle tracking echocardiography. Methods: In this prospectively designed study, 44 patients who were going to start intravitreal anti-VEGF treatment were included in the study. Patients were evaluated with speckle tracking echocardiography before the first anti-VEGF administration and at three months of anti-VEGF treatment. Results: Global longitudinal strain (GLS) values at three months were lower in the patients who participated in the study and this was statistically significant (−18.77±2.17, −18.60±2.01, p=0.001). Also, there was a statistically significant decrease in the mean values of GLS (GLS4CH) obtained from apical four space image, GLS (GLSAPLAX) obtained from apical long axis image and GLS (GLS2CH) obtained from apical 2 space image at month 0 and month 3 (−19.08±2.39, −18.93±2.26, p=0.004; −18.81±2.29, −18.60±2.12, p=0.001; −18.44±2.31, −18.27±2.12, p=0.013, respectively). Conclusion: The slight decrease in GLS in our study suggests that the use of intravitreal anti-VEGF agents may have cardiac effects
