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Esomeprazole Potentiates the Cytotoxic Effects of Cisplatin in Gastric Carcinoma Cells
No full textProton pump inhibitors (PPIs), including esomeprazole, impact the acidic tumor microenvironment, potentially influencing cancer cell behavior. By examining the combined effects of esomeprazole and cisplatin on SNU-1 gastric carcinoma cells, this study sought to elucidate the mechanisms through which esomeprazole enhances cisplatin's cytotoxicity, potentially allowing for effective treatment with reduced cisplatin dosages. SNU-1 cells were treated with varying doses of esomeprazole and cisplatin, alone and in combination. Cell viability was assessed using the XTT assay. Oxidative stress (TAS/TOS), apoptosis (Annexin V, cleaved PARP), mitochondrial membrane potential, and DNA damage (8-oxo-dG, γH2AX, ATM) were evaluated using flow cytometry and ELISA. Statistical significance was determined by ANOVA. Esomeprazole alone showed no significant effect on SNU-1 cell viability, oxidative stress (TAS/TOS), apoptosis, mitochondrial membrane potential, or DNA damage. Cisplatin, however, significantly reduced cell viability (IC50 = 3.024 µg/mL), increased oxidative stress (decreased TAS, increased TOS), diminished apoptosis (increased Annexin V binding and cleaved PARP levels), disrupted mitochondrial membrane potential, and caused significant DNA damage (increased H2AX and ATM phosphorylation, and elevated 8-oxo-dG) (p < 0.001). Notably, the combination of esomeprazole and cisplatin synergistically enhanced cisplatin's effects. The combination resulted in a significantly greater reduction in cell viability (CI < 1), a further increase in oxidative stress, a higher level of apoptosis, amplified mitochondrial depolarization, and potentiated DNA damage compared to cisplatin alone (p < 0.001). Esomeprazole potentiates cisplatin-induced cytotoxicity in SNU-1 gastric cancer cells by enhancing oxidative stress, apoptosis, mitochondrial dysfunction, and DNA damage. This suggests a potential therapeutic strategy to improve cisplatin efficacy and overcome resistance in gastric cancer
TOURISM REVENUES AND ECONOMIC GROWTH: A PANEL DATA ANALYSIS OF MEDITERRANEAN COASTAL COUNTRIES
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Statistical and seismotectonic analyses of the Marmara region under existing stress regime in the west of the NAFZ
No full textThe Marmara Region is an active tectonic region in northwestern Türkiye, which comprises some important strike-slip active fault mechanisms and important tectonic units, located near the western part of the North Anatolian Fault Zone. In the historical and instrumental period, the Marmara Region experienced large/devastating earthquakes. Considering this continuous activity, in this study, we investigate the tectonic structure and performed future seismic hazard estimation of the region based on some seismotectonic parameters. For this evaluation, we plot the Coulomb stress change maps of 1912 Mürefte-Şarköy, 1953 Yenice-Gönen and 1999 İzmit mainshocks with the earthquakes (MW ≥ 4.5) that occurred in the study region after 2003. For the estimation of b-value, occurrence probabilities and return periods of earthquakes, we used a homogenous local seismicity catalogue consisting of 119.029 events for the period between 1912 and 2023. In the findings of this study, the lower b-values and increasing Coulomb stress changes which are trigger stress failure compatible are observed in the west and northwest of the Marmara Sea. In contrast, the higher/moderate b-values and decreasing Coulomb stress values are observed in the east and southeast of the Marmara Sea. The results of probability assessments show that an earthquake with Mw = 6.5 may occur with a probability of 98% in the west of the Marmara Sea after 2025. As a remarkable fact, a comprehensive assessment of these types of variables will supply important findings for earthquake hazard and potential in the study region
Innovative Contributions of Space Research to Other Sectors: Recommendations for Technology Policy Makers
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Spatiotemporal variations in the levels of toxic elements in drinking water of Sivas, Türkiye, and an ecotoxicological risk assessment
No full textThis study was conducted in 2022 to investigate the water variables of fountains used by people for drinking purposes in Şarkışla (Sivas, Türkiye). Five stations were selected from the most frequently used fountains. Sampling was carried out seasonally. Various physicochemical variables such as water temperature (WT), pH, electirical conductivity (EC), dissolved oxygen (DO), nitrite (NO2), nitrate (NO3), phosphate (PO4), sulphate (SO4), magnesium (Mg), calcium (Ca), total hardness (TH), chloride (Cl), salinity, total dissolved solids (TDS), arsenic (As), cadmium (Cd), zinc (Zn), manganese (Mn), and copper (Cu) were investigated. Additionally, the Nitrate Pollution Index (NPI), Groundwater Quality Index (GWQI), and Human Health Risk Assesment (HHRA) methods were applied to the data. One of the main objectives of this study was to conduct health risk assessments for people using water from drinking fountains and to identify both carcinogenic and non-carcinogenic metals. As a result of this research, NPI values indicated slight contamination, while no contamination was found based on GWQI values. The Mn and Cd were found to slightly exceed the permissible limit values. As, which exceeds the limit value in water, was found to pose a serious carcinogenic risk (CR) for both children and adults. High As values are from quaternary alluvial deposits and aquifer layers of Pliocene terrestrial layers. Considering the hazard quotient (HQ) and hazard index (HI) for the presence of Cd, it was determined that it poses a serious risk to humans and children through both ingestive and dermal exposure. At the end of the study, several recommendations for the sustainable use of drinking fountains water were provided
