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Sunitinib treatment reduces proinflammatory cytokine levels and mortality rates by suppressing the NLRP3 inflammasome signaling pathway in sepsis
No full textBackground: Given the elevated mortality rates and significant treatment costs associated with sepsis, characterized by a dysregulated host response to infection and life-threatening organ dysfunction, the search for treatment strategies involving new and potentially effective agents is essential. Sunitinib, a tyrosine kinase inhibitor, shows promise for mitigating increased inflammation in sepsis through its modulation of specific molecular pathways. This study investigates the effects of sunitinib in the treatment of sepsis. Methods: Sepsis was induced in rats using the cecal ligation and puncture (CLP) model and sunitinib treatment was administered orally at various dosages. The effects of sunitinib treatment were evaluated through molecular and histopathological methods. The impact of sunitinib treatment on survival was analyzed using Kaplan–Meier survival analysis. Results: With low-dose treatment, sunitinib was observed to reduce the levels of proinflammatory cytokines, including interleukin-6, interleukin-8, and TNF-α. However, no reduction was observed with high-dose sunitinib in comparison to the sepsis group. Polymerase chain reaction results indicated that the NLRP3 inflammasome pathway was attenuated with low-dose sunitinib treatment. Furthermore, the extent of sepsis associated histopathological and immunohistochemical changes was reduced with sunitinib treatment, as demonstrated by hematoxylin and eosin staining and immunohistochemical analysis. Survival analysis revealed that the group receiving low-dose sunitinib had the highest survival rate. Conclusion: Different sunitinib doses in sepsis treatment yield significantly different molecular results, histopathological outcomes, and survival rates. A comprehensive investigation of tyrosine kinase inhibitor drugs such as sunitinib in the treatment of sepsis will enhance the efficacy of sepsis therapies
Kare kesitli AISI430/HARDOX450 çelik çiftinin sürtünme kaynak yöntemi ile birleştirilebilirliği
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Tularemi Tanılı Bir Hastada IgA Nefropatisi: Tesadüfi Bir İlişki mi Yoksa Nedensellik mi?
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Methane Production and Struvite Recovery from Disintegrated Biosludge at Different Microwave Powers
No full textThis study examined the impact of microwave (MW) irradiation on the disintegration of waste biological sludge (WBS) and CH4production during anaerobic digestion (AD), alongside the recovery of NH4−N and PO4−P via struvite precipitation in AD tailings. MW treatment was conducted under controlled conditions (120 °C and 2 °C/min) at the power levels of 900 W and 1,800 W. The soluble chemical oxygen demand (sCOD) increased by factors of 465 and 432 at 900 W and 1,800 W, respectively, while sugar and protein concentrations rose by factors of 840–110 and 1.93–2.15 compared to the untreated WBS. However, MW irradiation was less effective for releasing NH4−N and PO4−P. The disintegration of WBS improved CH4production in the biochemical methane potential (BMP) test by 26% and 35% at 900 W and 1,800 W, respectively, relative to the control. Despite these enhancements, the process was deemed uneconomical due to the high energy demand of MW irradiation compared to the energy gained from the increased CH4 yield. Additionally, the sludge dewatering properties, measured as sludge filter resistance (SFR), deteriorated significantly, increasing from 2.87 × 1014 for the untreated WBS to 6.50 × 1014 and 6.70 × 1014at 900 W and 1,800 W, respectively. Kinetic modeling of the BMP tests revealed that the Transference Function provided the best fit to the experimental data. In the struvite precipitation, the optimal recovery of NH4−N and PO4−P (96%) was achieved at a molar ratio of 1.25/1/1 for Mg/N/P.</p