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Assessing the productive capacity performance based on an integrated MCDM model: critical insights underlying the impact of the COVID-19 pandemic
No full textPhytochemical Characterization, Cytotoxic, and Antimicrobial Properties of Aerial Parts of Heliotropium hirsutissimum Weber: In Vitro and In Silico Approaches
No full textThis study evaluated the possible cytotoxic properties of the aerial parts of Heliotropium hirsutissimum Weber on MCF-7 and MDA-MB-231 breast cancer cell lines and also investigated its antimicrobial effects. Following the identification of the main components of the extract using gas chromatography–mass spectrometry analysis, molecular docking studies were performed using the PDB 6YD9 and PDB 6BRX targets. The crude methanol extract exhibited the most significant cytotoxicity against the MCF-7 and MDA-MB-231 cell lines, with IC50 values of 10.03 ± 0.02 and 14.36 ± 0.65 µg/mL, respectively. Among the tested extracts, the n-hexane sub-extract had modest efficacy against Staphylococcus aureus and Bacillus cereus, with a minimum inhibitory concentration of 0.625 mg/mL. In silico studies demonstrated that 3'-acetyllycopsamine and heliotrine had moderate affinity for the PDB 6YD9 target residue regions, with docking scores of −6.7 and −6.5 kcal/mol, respectively. The docking scores for 3'-acetyllycopsamine and heliotrine against PDB 6BRX were −6.7 and −6.6, respectively. Quinic acid showed strong affinity for the target residues in PDB 6YD9 and PDB 6BRX, with docking scores of −9.3 and −12.1 kcal/mol, respectively. This study suggests that H. hirsutissimum may have a potential effect on breast cancer. This effect may be attributed to the phenolic compounds and pyrrolizidine alkaloids. These findings indicate that H. hirsutissimum is a promising natural resource for future research in both the anticancer and antimicrobial fields
Yazma Eğitiminin İki Yüzü: Sınıf Öğretmenlerine Metin Yazmayı Öğretme Öz-Yeterlik İnancı İle 3 ve 4. Sınıf Öğrencilerinin Hikaye Yazma Tutumu
No full textDuygusal Zekâ Ölçeğinin Kısa Formunun Normal Ve Üstün Yetenekli Çocuklarda Psikometrik Özellikleri
No full textSynthesis, Biological Evaluation, Antiproliferative Activity, and Computational Insights of Carboxamide Derivatives: A Computational and Experimental Approach
No full textThe discovery of therapeutic agents is important for cancer treatment. Although dozens of agents have been used in cancer treatments, cancer continues to be a serious disease with a high mortality rate. There is an urgent need for the discovery of new anticancer agents, especially for the long-term treatment of prostate cancer. Thanks to the expansion of cancer-related data, we now can synthesize new therapeutic agents using biological methods. Carboxamide derivatives (5a–r compounds) were synthesized as a potential anticancer agent. Cell proliferation assays showed that they had antiproliferative activity against the human prostate cancer cell line PC3, particularly at the 25 μM dose. In summary, our findings revealed that 5g–l and 5m–r groups are effective agents against the prostate cancer cell line. In conclusion, Gaussian calculations were carried out in order to investigate carboxamide derivatives (5a–r compounds) at the B3LYP, HF, and M062X levels, using the 6–31++g(d,p) basis set. Molecular docking calculations were carried out on a variety of proteins, including the protein that is associated with prostate cancer (PDB ID: 3RUK and 3A99). Calculations using the ADME/T method are carried out in order to investigate the potential effects and reactions of these medicines on human metabolism
Synthesis, spectroscopic, DNA/BSA, Molecular Docking, and DFT studies of pyridine bis-benzimidazole compounds containing cinnamyl groups
No full textThis study analyzed the structures of novel pyridine bis-benzimidazole compounds containing mono- (ASM) and di-cinnamyl (DSM) groups using analytical and spectroscopic methods. The binding properties of the molecules to DNA and bovine serum albumin (BSA) were studied using UV-Vis absorption under physiological conditions. Compound ASM, which has an asymmetric structure, showed the highest DNA binding constant. The interactions of ASM and DSM with fish sperm DNA (FSds-DNA) were investigated through UV-Vis absorption and fluorescence spectroscopy using competitive DNA binding assays with rhodamine B (RB), ethidium bromide (EB), and methylene blue (MB). Binding studies with BSA revealed that compound ASM displayed the highest Ksv value. Molecular docking results showed that compound ASM exhibited a higher binding affinity with DNA, at -12.00 kcal/mol. Docking studies indicated that DSM demonstrated a higher activity affinity with BSA at -10.77 kcal/mol. These docking studies indicated that both compounds bind to DNA through a groove binding mechanism, with their binding sites on BSA located near Trp213. Computational analyses of the compounds were performed at the B3LYP-D3/6-31+G(d) level in a vacuum
Defect-engineered BiO1-xBr/BiOI1-x-CdS dual S-scheme heterojunction for enhanced photocatalytic cefixime degradation
No full textBackground The persistence of pharmaceutical contaminants such as cefixime (CFX) in aquatic systems poses serious environmental and health risks. Developing defect-engineered photocatalysts with efficient charge separation and enhanced visible-light activity is a critical strategy for wastewater remediation. Methods Hierarchical BiO1-xBr/BiOI1-x-CdS multicomponent heterostructure was rationally constructed via hydrothermal synthesis by integrating BiO1-xBr/BiOI1-x microflakes with CdS nanoflowers. The introduction of oxygen and iodine vacancies tailored the electronic configuration and strengthened interfacial coupling. Structural, spectroscopic, and photoelectrochemical analyses were performed to evaluate charge separation and transfer pathways. Photocatalytic activity was tested through CFX degradation under visible light. Reactive species trapping, electron spin resonance, and liquid chromatography-mass spectrometry have employed to identify active species and degradation intermediates. Findings The defect-engineered heterojunction exhibited a dual S-scheme charge transfer pathway that promoted efficient electron-hole separation and accelerated carrier migration due to the phenomenon of internal electric field and band bending, hence improving the CFX photodegradation efficiency. The BiO1-xBr/BiOI1-x-CdS photocatalytic system demonstrated a remarkable photocatalytic degradation efficiency of CFX, reaching approximately 95.8 % within 120 min under visible light at pH 6.0–6.5. In comparison to ternary, the CdS, BiO1-xBr, BiOI1-x, and BiO1-xBr/BiOI1-x reported photocatalytic reductions of only ∼46 %, ∼53 %, ∼62 %, and ∼79.4 % within same time period. Reactive species trapping and electron spin resonance analysis revealed that hydroxyl (.OH) and superoxide (-O2.) radicals were the dominant oxidative agents driving the degradation process. The catalyst maintained high structural integrity and stable photocatalytic activity over five consecutive cycles
Green synthesis of CuO adsorbent using Polygonum sivasicum for efficient adsorptive removal of Tetracycline hydrochloride
No full textGreen synthesis offers an environmentally sound and efficient route to producing copper oxide nanoparticles (CuO NPs (G)), which demonstrate significant potential for removing antibiotics from wastewater. This research details the production of CuO nanoparticles using an extract from the Polygonum sivasicum plant through a green synthesis approach. The resulting nanoparticles underwent comprehensive characterization using techniques such as Fourier Transform Infrared Spectroscopy (FTIR), Energy-Dispersive X-ray Analysis (EDX), Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD) and N2 adsorption–desorption analysis. Optimal conditions for tetracycline removal were identified as pH 5.0, a 24-h contact period, an adsorbent dosage of 1 g/L with 328 K temperature. Under these conditions, an initial pollutant concentration of 250 mg/L resulted in an 89% removal efficiency. The Langmuir isotherm model estimated a maximum adsorption capacity of 217.39 mg/g, and kinetic analysis indicated that the adsorption process aligns with the pseudo-second-order kinetic model. Thermodynamic analysis of tetracycline removal using CuO NPs (G) revealed its endothermic nature. The findings of this study underscore the advantages of employing a green synthesis method for producing CuO NPs (G) for tetracycline removal, particularly its economic viability and environmental compatibility. Furthermore, this work establishes the feasibility of synthesizing CuO NPs (G) from organic waste via green synthesis for the effective elimination of tetracycline
Family quality-of-life burden in chronic spontaneous urticaria: A multicentre study
No full textBackground: Chronic spontaneous urticaria (CSU) can cause psychosocial and quality of life burden on patients and their family members and caregivers. Despite its recognition as a debilitating disease, limited data exist regarding the impact of CSU on family members, hindering a comprehensive understanding of the disease's broader effects. This study aimed to assess how CSU affects the quality of life of family members who support patients in their daily challenges by applying the Family Dermatology Life Quality Index (FDLQI) questionnaire across multiple countries. Methods: A cross-sectional, multicentre and international study conducted between January and December 2024 in Urticaria Centres of Reference and Excellence (UCARE) centres located in several countries including Brazil, China, Ecuador, Greece, India, Oman, Poland, Russia, Thailand, Turkey, Peru and North Macedonia. Statistical analyses, including non-parametric tests and multiple regression models, were employed to explore associations between disease severity/control and family burden. Results: Poorly controlled CSU significantly deteriorated family members' quality of life, particularly in emotional, physical and social domains. Higher disease severity and lower disease control scores were associated with increased stress, greater caregiving burden and elevated health expenditures. In opposition to family relations, older age and longer time since diagnosis mitigate negative impacts, while insufficient treatment regimens exacerbated them. Conclusion: Inadequate control of CSU amplifies the burden on families, underscoring the need for effective and supportive care strategies