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Elder Fraud in the Mountain West, 2023
No full textThis fact sheet presents data on complaints of fraud affecting individuals over the age of 60 and associated financial losses reported by elderly individuals in the Mountain West. The 2023 Elder Fraud Report serves to illuminate trends in elder fraud reports throughout the 50 U.S. states, Washington, D.C., Puerto Rico, Guam, U.S. Minor Outlying Islands, American Samoa, U.S. Virgin Islands, and Northern Mariana Islands. This fact sheet focuses on elder fraud data for the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah
Recent Advances in Cardiac Resynchronization Therapy: Current Treatment and Future Direction
No full textCardiac Resynchronization Therapy (CRT) has been established as a major component of heart failure management, resulting in a significant reduction in patient morbidity and death for patients with increased QRS duration, low left ventricular ejection fraction (LVEF), and high risk of arrhythmias. The ability to synchronize both ventricles, lower heart failure hospitalizations, and optimize clinical outcomes are some of the attractive characteristics of biventricular pacing, or CRT. However, the high rate of CRT non-responders has led to the development of new modalities including leadless CRT pacemakers (CRT-P) and devices focused on conduction system pacing (CSP). This comprehensive review aims to present recent findings from CRT clinical trials and systematic reviews that have been published that will likely guide future directions in patient care
Molecular Mechanisms of L-Type Calcium Channel Dysregulation in Heart Failure
No full textThe L-type calcium channels (LTCCs) function as the main entry points that convert myocyte membrane depolarization into calcium transients, which drive every heartbeat. There is increasing evidence to show that maladaptive remodeling of these channels is the cause of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Recent experimental, translational, and clinical studies have improved our understanding of the roles LTCC expression, micro-domain trafficking, and post-translational control have in disrupting excitation–contraction coupling, provoking arrhythmias, and shaping phenotype specific hemodynamic compromise. We performed a systematic search of the PubMed and Google Scholar databases (2015–2025, English) and critically evaluated 17 eligible publications in an effort to organize the expanding body of work. This review combines existing data about LTCC density and T-tubule architecture with β-adrenergic and Ca2⁺/calmodulin-dependent protein kinase II (CaMKII) signaling and downstream sarcoplasmic reticulum crosstalk to explain how HFrEF presents with contractile insufficiency and how HFpEF shows diastolic calcium overload and stiffening. Additionally, we highlight the emerging therapeutic strategies aimed at restoring calcium homeostasis such as CaMKII inhibitors, ryanodine receptor type 2 (RyR2) stabilizers, and selective LTCC modulators without compromising systolic reserve. The review establishes LTCC dysregulation as a single mechanism that causes myocardial dysfunction while remaining specific to each phenotype, thus offering clinicians and researchers a complete reference for current concepts and future precision therapy approaches in heart failure
Advances in Mechanical Circulatory Support (MCS): Literature Review
No full textHeart failure is a heterogeneous disorder that can lead to cardiogenic shock. Mechanical circulatory support (MCS) devices can replace the cardiac function in an attempt to bridge patients to transplant or they can serve as destination therapy to improve overall patient functionality and in turn quality of life. Currently utilized MCS devices include devices such as Left Ventricular Assist Devices (LVADs), Biventricular Assist Devices (BiVADs), Impella, Total Artificial Hearts (TAHs), and extracorporeal membrane oxygenation (ECMO). This literature review examines a range of studies, case reports, and meta-analyses to present current approaches to mechanical circulatory support (MCS), along with the challenges and limitations of existing devices, common complications, and overall survival and long-term outcomes following MCS therapy
Fitness Changes, Dietary Practices and Sleep Quality in Non-Elite Through-hikers: A Case Series
No full textTopics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 13, 2025. Through-hikes on long distance backpacking routes have the potential to both improve physical fitness and pose health risks. PURPOSE: To quantify changes in cardiorespiratory fitness and body composition, while recording dietary intake and sleep habits in a sample of through-hikers. METHODS: Participants completed two lab visits consisting of a maximal graded treadmill test and body composition assessments. Hiking volume, energy expenditure, sleep duration, and sleep staging were estimated during the hike using a smart watch. Participants kept a journal of all food and beverage intake. RESULTS: Over the course of the hike, participants significantly increased their absolute VO2max (+0.5 ± 0.1 L/min, t = 5.242, p = 0.04) and relative VO2max (+12.1 ± 2.1 ml/kg/min, t = 5.708, p = 0.03). With respect to body composition, participants significantly decreased their body mass (-9.0 ± 1.4 kg, t = 6.67, p = 0.02) and fat mass (-6.8 ± 1.7 kg, t = 4.071, p = 0.05). There were no significant changes in lean mass (+1.09 ± 1.6 kg, t = 0.681, p = 0.57). Although all participants slept the recommended 7-9 hours per night on average, none met the advised amount of deep sleep per night. Hiker’s diets were lacking in energy sufficiency and were low in several micronutrients. CONCLUSION: Extended through-hiking may improve fitness while promoting low quality diets and sleep. Targeted dietary and sleep interventions could mitigate these effects and promote better health outcome
Effects of Fit Between Promotional Message and Regulatory Focus on Consumers’ Sports Betting Behavior: The Moderating Role of Consumers’ Familiarity
No full textThe sports gambling industry is an extremely competitive market. To attract more consumers, sports gambling platforms are primarily employing one of two customer acquisition strategies, namely ‘risk-free bet’ or ‘bonus money’ welcome offers. This research is built on regulatory fit theory to investigate the effectiveness of these two welcome offer strategies on consumers’ intentions to act on the offer. We further test the moderating effect of customers’ familiarity with online sports betting on their decision making. Findings of two experimental design studies demonstrate that the presence of regulatory fit between regulatory focus and promotional offers (i.e., message framing) positively affected the likelihood that consumers would exploit both promotional offers. In addition, for individuals with low familiarity with a product category, achieving a fit between their regulatory focus and the message framing positively moderated their likelihood of exploiting promotional offers
Hypnosis: An Evidenced Based Treatment
No full textReview of meta analyses and systemic review level studies of hypnosis in the treatment of anxiety, burnout, and depression
Obstetric Violence Awareness and Advocacy: Identifying Gender Based Violence in Maternity
No full textRecent trends of the excess of medical intervention during childbirth, particularly in uncomplicated births, along with an alarming spread of coercive and abusive practices towards women during childbirth requires immediate attention. This paper serves to address and bring awareness to the existence and extent of a form of gender-based violence, referred to as obstetric violence. The following in-depth literature review of 25 publications explores obstetric violence from various perspectives. In the discussion, I define the concept of obstetric violence and its forms of occurrence in care, examine conceptions and institutions which aid in the maintenance of the issue, suggest strategies for the potential elimination of obstetric violence, and propose future interviews with recent mothers and medical staff to further understand the implications of obstetric violence. Obstetric violence is a violation of human rights and a public health problem and demands global recognition and action
‘High-Stakes’ Security: Current and Emerging Trends in Casino Gaming Cybersecurity
No full textAlongside the digital evolution of the casino gaming industry, cybercrimes have emerged as a prominent threat to gaming businesses across the entire world. With the growing frequency of high-profile cyberattacks against major casino resorts and casino operators, the gaming industry has responded by implementing innovative cybersecurity strategies and resources to prevent and mitigate potential future assaults. This paper aims to examine cyber events in the gaming industry, how the industry has responded by enhancing its security posture, and what experts in the industry prioritize as security topics for future research. To accomplish this, a literature review was first performed to establish a foundation of literature on cybersecurity in the hospitality industry. Following this, secondary data analysis was conducted to identify gaming companies that have previously fallen victim to cybercrimes, the manner of intrusion, and the common security exploits used. Interviews with gaming industry experts were then conducted to determine which cybersecurity topics were perceived as especially salient to the current and future developments to gaming cybersecurity technologies and processes
Financial inducements in gambling marketing: An information disclosure proposal to inform gamblers of their true economic value
No full textFinancial inducements such as free bets are frequently-used gambling marketing offers which temporarily improve a gambler’s usual pattern of risk and potential return. Previous research has shown that there are up to 15 distinct types of financial inducements in common use, and that gamblers frequently misunderstand inducements’ play-through requirements and other complex terms and conditions. The Australian government has therefore recently banned play-through requirements for inducements shown to new customers, and the Great British regulator the Gambling Commission has recently announced a maximum play-through requirement of 10 times. The present work describes an alternative and yet potentially complementary approach based on disclosing financial inducements’ true economic value to gamblers. This approach can be motivated by the fact that financial inducements are not intrinsically harmful, and an understanding of their value has been exploited for profit by some gamblers via techniques called “bonus hunting” and “matched betting”. Disclosure-based approaches can be designed to reflect the average losses implied by any play-through requirements, as well as any other terms and conditions which affect their economic value. Disclosure-based approaches for protecting consumers from the potential harms of financial inducements should be subject to further research and policy consideration