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    From Post-Median Nerve Stimulation ERD to MI-BCI Expertise Prediction

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    International audiencePredicting performance in Motor Imagery-based Brain-Computer Interfaces (MI-BCIs) is essential for identifying potential users and improving system efficiency. This study investigates whether Event-Related Desynchronization (ERD) induced by Median Nerve Stimulation (MNS) can predict a user’s MI-BCI performance group (low, medium, or high) before system use. We analyzed neurophysiological features from post-MNS ERD using Linear Discriminant Analysis (LDA) and Least Absolute Shrinkage and Selection Operator (LASSO). Both achieved 74% accuracy for two-group classification (low vs. high performers), while hierarchical clustering demonstrated 83% accuracy for unsupervised classification, emphasizing MNS's discriminative power. For three-group classification, LDA performed best with 58% accuracy. Topographical analyses further revealed stronger ERD responses in motor-related areas for higher performers during both MNS and MI tasks, highlighting MNS-induced ERD as a reliable, practical and non-invasive predictor of MI-BCI performance levels for early user stratification and advanced personalized BCI

    Contrariété à l’ordre public international d’un jugement étranger d’adoption insuffisamment motivé

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    Un regard approfondi sur le comportement temporel des E/S des applications HPC — version étendue

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    The increasing gap between compute and I/O speeds in high-performance computing (HPC) systems imposes the need for techniques to improve applications' I/O performance. Such techniques must rely on assumptions about I/O behavior in order to efficiently allocate I/O resources such as burst buffers, to schedule accesses to the shared parallel file system or to delay certain applications at the batch scheduler level to prevent contention, for instance. In this paper, we verify these common assumptions about I/O behavior, specifically about temporal behavior, using over 440,000 traces from real HPC systems. By combining traces from diverse systems, we characterize the behaviors observed in real HPC workloads. Among other findings, we show that I/O activity tends to last for a few seconds, and that periodic jobs are the minority, but responsible for a large portion of the I/O time. Furthermore, we make projections for the expected improvement yielded by popular approaches for I/O performance improvement. Our work provides valuable insights to everyone working to alleviate the I/O bottleneck in HPC.L’écart croissant entre les vitesses de calcul et d’entrée/sortie dans les systèmes de de calcul à haute performance (HPC) impose le besoin de techniques pour améliorer les performances des applications en matière d’E/S. Ces techniques doivent s’appuyer sur des informations sur le comportement des E/S afin d’allouer efficacement les ressources d’E/S telles que les burst buffers, d’ordonnancer les accès au système de fichiers parallèle partagé ou de retarder certaines applications au batch scheduler pour éviter la contention, par exemple. Dans cet article, nous vérifions ces hypothèses courantes sur le comportement des E/S, en particuliersur le comportement temporel, en utilisant plus de 440 000 traces provenant de systèmes HPC réels. En combinant des traces provenant de divers systèmes, nous caractérisons les comportements observés dans les charges de travail HPC réelles. Entre autres résultats, nous montrons que l’activité E/S a tendance à durer quelques secondes, et que les travaux périodiques sont minoritaires, mais responsables d’une grande partie du temps d’entrée/sortie. En outre, nous établissons des projections concernant l’amélioration attendue des approches les plus courantes en matière d’amélioration des performances d’E/S. Notre travail fournit des informations précieuses à à tous ceux qui s’efforcent de réduire le goulot d’étranglement des E/S dans le domaine du calcul intensif

    Semiconducting overoxidized polypyrrole nano‐particles for photocatalytic water splitting

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    International audienceCapturing sunlight to fuel the water splitting reaction (WSR) into O2_2 and H2_2 is the leitmotif of the research around artificial photosynthesis. Organic semiconductors have now joined the quorum of materials currently dominated by inorganic oxides, where for both families of compounds the bandgaps and energies can be adjusted synthetically to perform the Water Splitting Reaction. However, elaborated and tedious synthetic pathways are necessary to optimize the photophysical properties of organic semiconductors. This study reports here, that when pyrrole dissolved distilled water is exposed to high energy radiation, this leads to the formation of nanostructured spherical polypyrrole (Nano‐PPy) particles that are characterized as overoxidized polypyrrole. Electrochemical studies and Tauc's plot highlight the production of a semiconducting material with a bandgap of ≈1.8 eV with the conduction band at ≈−0.5 V and a valence band at ≈+1.3 V vs NHE. When suspended in water and under irradiation at wavelengths higher than 420 nm, Nano‐PPy materials lead to O2_2 evolution, while electrons and protons can be recovered in the form of reduced quinone. Interestingly, upon intermittent visible irradiation and dark phases, a consumption of the evolved O 2 from oxidation of water is observed. This concomitant O2_2 reduction is found to produce H2_2 O2_2

    Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review

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    International audienceThis scoping review aims to summarize the current state of knowledge on the potential involvement of infections in age-related macular degeneration (AMD). Age-related macular degeneration is a multifactorial disease and the leading cause of vision loss among older adults in developed countries. Clarifying whether certain infections participate in its onset or progression seems essential, given the potential implications for treatment and prevention. Using the PubMed database, we searched for articles in English, published until June 1, 2023, whose title and/or abstract contained terms related to AMD and infections. All types of study design, infectious agents, AMD diagnostic methods, and AMD stages were considered. Articles dealing with the oral and gut microbiota were not included but we provide a brief summary of high-quality literature reviews recently published on the subject. Two investigators independently screened the 868 articles obtained by our algorithm and the reference lists of selected studies. In total, 40 articles were included, among which 30 on human data, 9 animal studies, 6 in vitro experiments, and 1 hypothesis paper (sometimes with several data types in the same article). Of these, 27 studies were published after 2010, highlighting a growing interest in recent years. A wide range of infectious agents has been investigated, including various microbiota (nasal, pharyngeal), 8 bacteria, 6 viral species, and 1 yeast. Among them, most have been investigated anecdotally. Only , , and hepatitis B virus received more attention with 17, 6, and 4 studies, respectively. Numerous potential pathophysiological mechanisms have been discussed, including (1) an indirect role of infectious agents (i.e. a role of infections located distant from the eye, mainly through their interactions with the immune system) and (2) a direct role of some infectious agents implying potential infection of various cells types within AMD-related tissues. Overall, this review highlights the diversity of possible interactions between infectious agents and AMD and suggests avenues of research to enrich the data currently available, which provide an insufficient level of evidence to conclude whether or not infectious agents are involved in this pathology. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article

    Halving heart failure outcomes by finerenone-mediated type 2 diabetes prevention.

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