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Toward an understanding of microalgae EPS-based selectivity and binding mechanisms for trace metal ions using Love wave acoustic and voltammetric sensors in seawater
No full textInternational audienceA biosensor using microalgal extracellular polymeric substances (EPS) for real-time monitoring of six trace metals in seawater, combining acoustic and electrochemical signatures for high sensitivity
Insights into the pathogenesis and differential diagnosis of clival lesions in an individual from a 16th-century-CE mass grave at Mohács (Southwestern Hungary)
No full textInternational audienceThe aim of our paper is to present and discuss in detail the pathological lesions suggestive of tuberculosis observed in a skeleton ( MMG3–75 ) that was excavated from the 16 th -century-CE mass grave No. 3 of the Mohács National Memorial Site (Sátorhely, southwestern Hungary). The differential diagnoses of the observed bony changes, with special attention to the clival alterations, are presented. During the macromorphological, radiological, and digital microscopic examination of MMG3–75 , the skull base showed mild cortical erosion and multiple, well-circumscribed osteolytic lesions at the clivus clearly evidenced by 3D imaging. In addition, endocranial granular impressions and abnormal blood vessel impressions were observed in multiple locations on the inner skull surface. Based on the differential diagnosis of the clival changes and their co-occurrence with endocranial alterations indicative of tuberculous meningitis (granular impressions and abnormal blood vessel impressions), they were most likely due to tuberculous involvement of the skull base. Additional aDNA analysis provided no evidence for the presence of Mycobacterium tuberculosis DNA in MMG3–75 . To the best of our knowledge, MMG3–75 is the first reported archaeological case of tuberculous clival osteomyelitis with associated meningitis, giving us a unique insight into the occurrence of an extremely rare manifestation of tuberculosis in mediaeval Hungary
First and disturbing records of the bivalve molluscs Potamocorbula amurensis (Schrenck, 1861) and Mulinia lateralis (Say, 1822) in the Bay of Biscay (France)
No full textInternational audienceThe bivalve mollusc Potamocorbula amurensis, a Corbulidae from the Asian coasts, was recorded for the first time in France in September 2023 in the Gironde estuary, and subsequently in September 2024 in Aiguillon Cove and Aytré Bay. In Aytré Bay, it was accompanied by another non-native bivalve not previously reported from French coasts, Mulinia lateralis, a Mactridae from the western Atlantic coasts. These two species were first recorded in Europe in 2018 in the Westerschelde (Netherlands, Belgium) and are known to be potentially highly invasive. Particular attention should be paid to monitor the spread and the establishment of these two euryoecious species along European coasts.</div
An hybrid stochastic Newton algorithm for logistic regression
No full textIn this paper, we investigate a second-order stochastic algorithm for solving large-scale binary classification problems. We propose to make use of a new hybrid stochastic Newton algorithm that includes two weighted components in the Hessian matrix estimation: the first one coming from the natural Hessian estimate and the second associated with the stochastic gradient information. Our motivation comes from the fact that both parts evaluated at the true parameter of logistic regression, are equal to the Hessian matrix. This new formulation has several advantages and it enables us to prove the almost sure convergence of our stochastic algorithm to the true parameter. Moreover, we significantly improve the almost sure rate of convergence to the Hessian matrix. Furthermore, we establish the central limit theorem for our hybrid stochastic Newton algorithm. Finally, we show a surprising result on the almost sure convergence of the cumulative excess risk
Gender-Affirming Hormone Therapy and Vascular Health: Walking the Line Between Caution and Confidence
No full textAbstract Aim Cardiovascular (CV) risk assessment in transgender individuals remains poorly understood. Emerging data suggest a potential increase in CV risk associated with gender-affirming hormone therapy(GAHT). Conventional tools such as coronary artery calcium(CAC) scoring may underestimate risk in this young population. Advanced imaging techniques (coronary computed tomography angiography CCTA and 3-dimensional supra-aortic trunk ultrasonography SATUS) may provide more accurate evaluation, but their relevance in transgender cohorts has not yet been established. We aimed to assess early CV risk modification of GAHT using several innovative imaging techniques. Methods We conducted a prospective, single-center study at Bordeaux University Hospital, enrolling transgender individuals initiating or continuing GAHT. Participants undergone clinical and biological assessment and CV imaging(CAC, CCTA, SATUS) at baseline and after 18months. Results Thirty-four participants (17transmen (TM), 17transwomen (TW) were included. At baseline, TM were younger than TW (22.7±5.3 vs 29.7±9.7years,p=0.008), had higher HDLc (1.36 vs 1.18mmol/L,p=0.01), and higher smoking prevalence (70.6% vs 11.8%, p=0.001). Both groups had a CAC score and carotid plaque volume of zero. During follow-up, TW showed a modest increase in carotid plaque volume and CAC scores, whereas TM showed no change. Progression of coronary plaque volume was observed in 70% of TW compared with 22% of TM, indicating a clear, although non-significant, trend toward greater atherosclerotic development in TW. Conclusion This pilot study suggests a more pronounced progression of atherosclerosis in TW undergoing GAHT, detectable particularly through CCTA. These findings support refined CV monitoring and highlight the need for larger, long-term studies to guide preventive strategies in transgender populations
Quand les outils libèrent (ou brident) l’initiative au travail
No full textArticle publié en ligne à l'adresse https://management-datascience.org/articles/42110/Grist est un logiciel sous licence libre, à mi-chemin entre le tableur et le système de gestion de bases de données, apparenté aux outils no code ou low code. Son adoption rapide dans l'administration française nous encourage à comprendre les mécanismes de ce que les spécialistes nomment end-user development (développement par l'utilisateur final), une approche riche de promesses pour libérer la créativité des collaborateurs et favoriser leur appropriation et leur maîtrise des outils à leur disposition. La comparaison entre Grist et l'omniprésent logiciel Excel permet de mettre en avant sa plus value dans une démarche de gestion des données exemplaire
Définir l’usage des études d’impact dans un contexte de transition sociétale : de l’intérêt de mobiliser les parties prenantes
No full textInternational audienceAt a time when many uncertainties are weighing on European non-financial reporting requirements, our qualitative study looks at possible transpositions, to private companies, of the achievements of various fields of activity, often regulated, in terms of impact assessment. Our analysis calls for a renewal of the relationship with stakeholders in the interest of responsible strategies adapted to contemporary challenges.Alors que de nombreuses incertitudes pèsent sur les exigences de communication extra-financière européennes, notre recherche qualitative s’intéresse aux transpositions possibles, aux entreprises privées, des acquis de divers champs d’activité, souvent réglementés, en matière d’évaluation d’impact. Notre analyse invite à un renouvellement de la relation aux parties prenantes afin de servir des stratégies responsables adaptées aux enjeux contemporains
Gene silencing targeting uk1_LRR or clathrin in the experimental vector Euscelidius variegatus modifies insect colonization by "flavescence dorée" phytoplasma
No full textInternational audienceThe “flavescence dorée” (FD) phytoplasma is transmitted from grapevine to grapevine by the leafhopper Scaphoideus titanus. In experimental conditions, this phytoplasma is also transmitted by the leafhopper Euscelidius variegatus to broad bean in which it multiplies and induces symptoms. To be transmitted to plants, phytoplasmas must invade different cell types of their insect vectors. The process of cellular endocytosis involves both bacterial and eucaryotic factors such as adhesins and receptors. In the present study, it is shown that entry of fluorescent beads coated with the adhesin VmpA of the FD phytoplasma into cultured E. variegatus cells depends on the putative receptor Uk1_LRR and clathrin of the insect. In vivo experiments have shown that silencing of uk1_LRR gene increased the colonization of E. variegatus by the FD phytoplasmas without effect on the plant transmission. On the contrary, silencing of clathrin gene significantly reduced the colonization of E. variegatus and the transmission to broad bean
In vitro production of (+)-catechin and (−)-epicatechin glucuronides to better understand the in vivo metabolism of a polyphenol-rich extract (Memophenol™)
No full textInternational audienceConsumption of (+)-catechin and (−)-epicatechin is associated with beneficial effects on human health. However, their limited systemic circulation in native form suggests that their metabolites may contribute to these effects. The aim of this study was to produce and structurally characterize glucuronide metabolites of (+)-catechin and (−)-epicatechin, which are not commercially available, and to assess their presence in plasma from volunteers who consumed a blend of grape and wild blueberry extracts. Firstly, four monoglucuronides of each flavanol were produced using rat liver microsomes and characterized by UHPLC-DAD-MS/MS and NMR. Using these compounds, we were able to confirm the presence in human plasma of three glucuronides: one known (−)-epicatechin glucuronide and two previously unidentified (+)-catechin glucuronides. Further research is needed to understand their biological role